In a study published in Molecular Neurodegeneration an international group of scientists including researchers from KTH have used a multiplex plasma profiling assay and a well-described genetic frontotemporal dementia (FTD) cohort collected within the GENFI study to explore potential plasma biomarkers that could reflect the pathology of this disease...Read more

How can sperm swim? The outer dense fiber of sperm tails 4 (gene: ODF4) is one of the proteins thought to be important for sperm tail movement that propels the sperm forward. Multiplex immunohistochemistry technique enabled us to examine the expression of this protein during sperm development (spermatogenesis) in more detail than ever before...Read more

Proper three-dimensional structure of proteins is paramount to their function, and misfolded proteins not only lead to loss of that function but to aggregates that can disrupt cellular processes. In ideal conditions, proteins fold spontaneously into their native three-dimensional structures, driven by their amino acid sequence (Ellis, 1999). However, in the crowded and stressed environment of the cell, assistance is often required to avoid misfolding and aggregation. This week we highlight heat shock protein 60 (HSP60), pictured here in the mitochondria of U2OS cells. As a member of the class 1 chaperonin family, HSP60 assists in the folding of newly translated, imported, or denatured proteins in the mitochondrial matrix, particularly under conditions of stress such as high temperatures or UV light ( Hartl, 1996)...Read more

In a study published in Molecular Therapy researchers from KTH among others have generated several different DNA vaccines selectively activating neutralizing antibodies (Nabs) and/or T cells and used them in different animal models to study their individual roles in the protection against severe SARS-CoV-2...Read more