News Articles


Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiform

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Glioblastoma multiforme (GBM) is one of the most malignant central nervous system tumors, showing a poor prognosis and low survival rate. Therefore, deciphering the underlying molecular mechanisms involved in the progression of the GBM and identifying the key driver genes responsible for the disease progression is crucial for discovering potential diagnostic markers and therapeutic targets...Read more


Advances and Utility of the Human Plasma Proteome

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Human blood provides an easily obtainable, extensive, and sensitive diagnostic material for the assessment of wellness and disease in individuals and populations. The abundance of proteins and their primary isoforms, alternative splice isoforms, post-translational modifications (PTMs), and protein sequence variants provide a distinct snapshot into the current function of the circulatory system and all organs with which blood comes in contact...Read more


Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptons

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Researchers within HPA have demonstrated the usefulness of "next generation plasma protein profiling" to identify molecular signatures of importance for disease progression and to allow monitoring of disease during recovery from COVID-19. The results will facilitate further studies to understand the molecular mechanism of the immune-related response of the SARS-CoV-2 virus...Read more


Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers

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Pyruvate kinase muscle type (PKM) is a key enzyme in glycolysis and is a mediator of the Warburg effect in tumors. The association of PKM with survival of cancer patients is controversial. This study investigated the associations of the alternatively spliced transcripts of PKM with cancer patients' survival outcomes and explained the conflicts in previous studies. The article has recently been published in the journal Cancers...Read more


A multi-scale map of cell structure fusing protein images and interactions

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The cell is a multi-scale structure with modular organization across at least four orders of magnitude. Two central approaches for mapping this structure — protein fluorescent imaging and protein biophysical association — each generate extensive datasets, but of distinct qualities and resolutions that are typically treated separately. Here we present a computational framework to build a unified hierarchical map of human cell architecture...Read more


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