The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Weak to moderate staining was found in all malignant cells. Single cases of strong staining were also found. Distinct granular staining was found in e.g. liver cancers. Lymphomas were negative or weakly stained.
Cholangiocarcinomas in liver and several colorectal cancers showed strong cytoplasmic immunoreactivity. Testicular cancers along with several ovarian, urothelial and renal cancers were negative. Remaining malignant cells generally showed weak to moderate cytoplasmic positivity.
Colorectal and occasional testicular cancers displayed strong cytoplasmic immunoreactivity. All other cancers exhibited weak to moderate staining.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
