The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignancies exhibited weak to moderate cytoplasmic positivity in the majority of cases. Additional membranous and nuclear positivity was observed in several cases. Rare prostate, cervical, liver and pancreatic cancers showed strong positivity. Malignant lymphomas, carcinoids and gliomas along with most testicular and colorectal cancers were negative.
Colorectal cancers and a few breast cancers showed strong cytoplasmic and membranous staining. Malignant gliomas, lymphomas and melanomas as well as most skin and renal cancers were negative. Remaining malignant cells showed in general weak to moderate staining.
One antibody yielding a staining pattern and there is no available gene/protein characterization data or the staining pattern is partly consistent with or contradicted by limited gene/protein characterization data
The multi-targeting antibody yielding a staining pattern partly consistent with limited gene/protein characterization data or there is no available gene/protein characterization data for all or at least one of the genes