The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients).
By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Several Hodgkins lymphomas, colorectal and stomach cancers along with a few ovarian, endometrial, prostate, liver and pancreatic cancers displayed moderate to strong cytoplasmic and/or membranous immunoreactivity. Remaining cancer cells were weakly stained or negative.
Differential staining pattern with cytoplasmic positivity ranging from weak to strong intensity was observed mainly in malignant gliomas, lymphomas, testicular cancers and breast cancers. Most other tumors were weakly stained.
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for all of the genes
One antibody yielding a staining pattern which is partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Level of antibody staining/expression
High Medium Low Not detected
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.