< No: 21 >

The Tissue Atlas

The Tissue Atlas was launched in 2015. This new atlas contained information regarding the expression profiles in human tissues and organs on both the messenger RNA (mRNA) and protein level. 76 different cell types were analyzed, corresponding to 44 normal human tissue types, and the data was presented using pathology-based annotation of protein expression levels. A genome-wide analysis of all protein-coding genes was presented with regards to whole-body expression profiles.

Key publication

Other selected publications

  • Fagerberg L et al., Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. (2014)
    PubMed: 24309898 DOI: 10.1074/mcp.M113.035600

  • Djureinovic D et al., The human testis-specific proteome defined by transcriptomics and antibody-based profiling. Mol Hum Reprod. (2014)
    PubMed: 24598113 DOI: 10.1093/molehr/gau018

  • Kampf C et al., The human liver-specific proteome defined by transcriptomics and antibody-based profiling. FASEB J. (2014)
    PubMed: 24648543 DOI: 10.1096/fj.14-250555

Figure legend: Global expression profiles of human genes on both the mRNA and protein level. Adapted from M. Uhlén et al. (2015).

Key facts

  • A genome-wide classification of all protein-coding genes was introduced with regard to tissue profiles
  • Various subproteomes were analyzed, such as the druggable proteome and the housekeeping proteome
  • The analysis showed that only 3% of the genes are specific for a single tissue
  • The Tissue Atlas paper published in Science (see Key Publication, above) has been cited many thousands of times (Google Scholar)