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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q26.3
Chromosome location (bp)
98648539 - 98964530
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001965[G-protein alpha-subunit binding] GO:0003230[cardiac atrium development] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005009[insulin receptor activity] GO:0005010[insulin-like growth factor receptor activity] GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005520[insulin-like growth factor binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005899[insulin receptor complex] GO:0005901[caveola] GO:0006468[protein phosphorylation] GO:0006955[immune response] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007409[axonogenesis] GO:0007568[aging] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010656[negative regulation of muscle cell apoptotic process] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0021549[cerebellum development] GO:0021766[hippocampus development] GO:0030010[establishment of cell polarity] GO:0030315[T-tubule] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0031175[neuron projection development] GO:0031667[response to nutrient levels] GO:0031994[insulin-like growth factor I binding] GO:0032467[positive regulation of cytokinesis] GO:0032868[response to insulin] GO:0032869[cellular response to insulin stimulus] GO:0033197[response to vitamin E] GO:0033674[positive regulation of kinase activity] GO:0033690[positive regulation of osteoblast proliferation] GO:0034224[cellular response to zinc ion starvation] GO:0035094[response to nicotine] GO:0035867[alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0038083[peptidyl-tyrosine autophosphorylation] GO:0042593[glucose homeostasis] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043235[receptor complex] GO:0043243[positive regulation of protein-containing complex disassembly] GO:0043409[negative regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0043548[phosphatidylinositol 3-kinase binding] GO:0043559[insulin binding] GO:0043560[insulin receptor substrate binding] GO:0044849[estrous cycle] GO:0044877[protein-containing complex binding] GO:0045056[transcytosis] GO:0045471[response to ethanol] GO:0046328[regulation of JNK cascade] GO:0046777[protein autophosphorylation] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0048680[positive regulation of axon regeneration] GO:0051054[positive regulation of DNA metabolic process] GO:0051897[positive regulation of protein kinase B signaling] GO:0071260[cellular response to mechanical stimulus] GO:0071333[cellular response to glucose stimulus] GO:0071392[cellular response to estradiol stimulus] GO:0071393[cellular response to progesterone stimulus] GO:0071394[cellular response to testosterone stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0090031[positive regulation of steroid hormone biosynthetic process] GO:0090398[cellular senescence] GO:0097062[dendritic spine maintenance] GO:0097242[amyloid-beta clearance] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0140318[protein transporter activity] GO:1902065[response to L-glutamate] GO:1902911[protein kinase complex] GO:1903944[negative regulation of hepatocyte apoptotic process] GO:1904045[cellular response to aldosterone] GO:1904193[negative regulation of cholangiocyte apoptotic process] GO:1904385[cellular response to angiotensin] GO:1904646[cellular response to amyloid-beta] GO:1990314[cellular response to insulin-like growth factor stimulus]