Protein detected in human plasma by mass spectrometry

In this chapter the estimated concentrations of proteins detected in human plasma based on mass spectrometry-based proteomics is presented. Protein concentrations were quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in the publicly available Peptide Atlas build (Human Plasma 2023-04). This data set contains estimated concentrations for 4066 proteins, including both proteins that are actively secreted to plasma, but also locally secreted proteins and intracellular proteins that leak into the blood stream.

Figure 1. The plot shows the concentration rank for each protein in relation to the 4066 proteins in the Peptide Atlas plasma build (x-axis) as well as estimated concentration on an absolute scale (left y-axis) with some reference proteins denoted. The bars are coloured according to location and by using mouse-over, the concentration and category for all individual proteins are displayed.The most abundant proteins in blood - for example Albumin (40 g/l) - are not shown since they have been depleted in most samples.

Table 1. A list of the proteins detected in blood by mass spectrometry.

Gene Gene description Concentration
CP Ceruloplasmin 440 mg/L
IGHG2 Immunoglobulin heavy constant gamma 2 (G2m marker) 250 mg/L
GSN Gelsolin 240 mg/L
IGHG1 Immunoglobulin heavy constant gamma 1 (G1m marker) 230 mg/L
RBP4 Retinol binding protein 4 210 mg/L
C3 Complement C3 200 mg/L
HPX Hemopexin 190 mg/L
A2M Alpha-2-macroglobulin 170 mg/L
IGHG4 Immunoglobulin heavy constant gamma 4 (G4m marker) 170 mg/L
FGA Fibrinogen alpha chain 140 mg/L
SERPINA1 Serpin family A member 1 140 mg/L
IGHA1 Immunoglobulin heavy constant alpha 1 130 mg/L
SERPINC1 Serpin family C member 1 120 mg/L
C4B Complement C4B (Chido blood group) 120 mg/L
CFB Complement factor B 120 mg/L
C4A Complement C4A (Rodgers blood group) 120 mg/L
APOA1 Apolipoprotein A1 110 mg/L
AHSG Alpha 2-HS glycoprotein 110 mg/L
FGB Fibrinogen beta chain 110 mg/L
IGHM Immunoglobulin heavy constant mu 110 mg/L
CFH Complement factor H 100 mg/L
APOB Apolipoprotein B 100 mg/L
PRSS1 Serine protease 1 100 mg/L
HP Haptoglobin 100 mg/L
TTR Transthyretin 99 mg/L
TF Transferrin 98 mg/L
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