The spinal cord is part of the central nervous system that extends from the medulla oblongate. It is situated inside the vertebral canal and is the major link between body and brain. The spinal cord controls movement, processes sensory information like touch, vibration or presure (mechanoreception), temperature (thermoception), postion of lims (proprioception) and pain (nociception) but also controls autonomous functions like blood pressure, heart rate, body temperature and bodily functions like breathing, bladder control and bowel movements.
The transcriptome analysis shows that 67% (n=13529) of all human protein-coding genes (n=20090) are expressed in the human spinal cord grey matter, and that 13109 of all pig orthologues (n=15829) are expressed in the pig spinal cord.
The spinal cord extends from the medulla oblongate and is situated inside the vertebral canal. Based on the corresponding vertebrae level spinal cord is divided into the cervical (C1-8), thoracic (T1-12), lumbar (L1-5) and sacral (S1-5) segments. Spinal cord grey matter can be divided in dorsal horn, central grey and ventral horn. The dorsal horn comprises of sensory nuclei that process somatosensory input from sensory neurons. Motor neurons innervating skeletal muscles are located in the ventral horn. The intermediate column also containing the central grey is involved in controlling autonomic motor functions. The spinal cord white matter is divided in three tracts, the dorsal funiculus, lateral funiculus and anterior funiculus. The dorsal funiculs, also known as posterior funiculus, contains mainly ascending sensory fibers. The lateral and anterior funiculi contain ascending sensory fibers (spinothalamic tract) and descending motor fibers (corticospinal tract).
Regionally elevated protein expression in human
Table 2. The 4 genes with the highest level of enriched expression in human white matter. "Predicted localization" shows the classification of each gene into three main classes: Secreted, Membrane, and Intracellular, where the latter consists of genes without any predicted membrane and secreted features. RS-score (Regional Specificity score) corresponds to the score calculated as the fold change to the second highest region.
Regionally elevated protein expression in pig