The Cell Atlas
The Cell Atlas provides high-resolution insights into the expression and spatio-temporal distribution of RNA and proteins in human cell lines. Genome-wide mRNA expression is determined by deep RNA-sequencing in a panel of 69 cell lines, representing various cell populations in different organs and tissues of the human body. The subcellular distributions of proteins encoded by 12813 genes (65% of the human protein-coding genes) are investigated in a subset of cell lines selected based on corresponding RNA expression. Protein localization data is derived from antibody-based profiling, using immunofluorescence (ICC-IF) and confocal microscopy, and classified into 35 different organelles and fine subcellular structures. The Cell Atlas offers a database for detailed exploration of individual genes and proteins of interest, as well as for systematic analysis of transcriptomes and proteomes in broader contexts, in order to increase the understanding of human biology at the cellular and subcellular levels.