Nuclear speckles

 Staining of nuclear speckles in human cell line A-431 (HPA041411)
Scale bar represents 10µm

Nuclear speckles

Nuclear speckles are a non-membrane-bound nuclear sub-compartment that contains pre-mRNA splicing factors. Besides the storage of those splicing factors nuclear speckles are thought to serve as a regulatory site for transcription.

Immunofluorescent staining

Nuclear speckles appear as an irregular, mottled staining pattern inside the nucleoplasm.

Read more about the nuclear proteome.