Brain tissue expression of ATP1A2 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	527.2	nTPM
FANTOM5:	1166.4	Scaled Tags Per Million

Mouse:	462.8	nTPM
Rat:	843.0	nTPM
Pig:	449.9	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	527.2

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 313.3

1984	Male, age 76, both hemispheres	453.4
2301	Female, age 85, both hemispheres	296.0
2090	Male, age 80, both hemispheres	284.3
2188	Female, age 91, both hemispheres	219.5

Dorsal cochlear nucleus
nTPM: 527.2

2802	Male, age 74, right hemisphere	663.3
2370	Male, age 61, both hemispheres	598.6
2058	Male, age 76, both hemispheres	574.2
2378	Male, age 80, both hemispheres	486.5
2187	Female, age 91, both hemispheres	313.4

Dorsal tegmental nucleus
nTPM: 394.7

1936	Male, age 76, left hemisphere	524.5
2083	Male, age 80, both hemispheres	502.5
2326	Male, age 74, both hemispheres	430.7
2358	Male, age 61, both hemispheres	121.0

Dorsolateral tegmental area
nTPM: 371.6

2654	Male, age 80, both hemispheres	497.4
2751	Female, age 85, both hemispheres	481.5
2141	Male, age 76, both hemispheres	442.8
2360	Male, age 74, both hemispheres	350.0
2337	Male, age 61, both hemispheres	86.5

Kolliker-Fuse nucleus
nTPM: 425.5

2315	Male, age 76, right hemisphere	616.6
2163	Male, age 80, both hemispheres	424.8
2793	Female, age 91, left hemisphere	235.1

Lateral lemniscal nuclei
nTPM: 335.2

2169	Male, age 76, both hemispheres	457.7
2453	Male, age 74, right hemisphere	407.4
2036	Male, age 80, both hemispheres	298.9
2746	Female, age 85, left hemisphere	283.9
2320	Female, age 91, left hemisphere	228.0

Lateral parabrachial nucleus
nTPM: 337.0

2139	Female, age 85, right hemisphere	479.0
2792	Male, age 76, both hemispheres	408.8
2013	Male, age 80, both hemispheres	342.3
2790	Male, age 61, both hemispheres	118.0

Lateral vestibular nucleus
nTPM: 476.9

2184	Male, age 76, both hemispheres	546.2
2311	Male, age 80, both hemispheres	407.6

Locus coeruleus
nTPM: 399.7

2317	Female, age 72, unknown	483.6
2788	Male, age 74, unknown	475.7
1980	Male, age 76, both hemispheres	398.8
2123	Female, age 91, both hemispheres	397.3
2014	Male, age 55, unknown	374.4
2720	Male, age 74, both hemispheres	337.1
2162	Male, age 80, both hemispheres	330.9

Medial parabrachial nucleus
nTPM: 364.9

2786	Male, age 76, both hemispheres	479.6
2463	Female, age 85, right hemisphere	415.2
2854	Male, age 80, both hemispheres	356.2
2170	Female, age 91, both hemispheres	348.4
2156	Male, age 61, both hemispheres	225.2

Medial periolivary nuclei
nTPM: 315.5

2063	Male, age 76, both hemispheres	418.6
2791	Male, age 74, right hemisphere	341.3
2171	Female, age 85, both hemispheres	322.1
2458	Female, age 91, both hemispheres	278.2
2081	Male, age 80, both hemispheres	217.6

Motor facial nucleus
nTPM: 382.3

2795	Female, age 91, both hemispheres	764.1
2062	Male, age 76, both hemispheres	513.3
2126	Male, age 61, both hemispheres	332.4
2365	Male, age 74, right hemisphere	293.1
2327	Male, age 80, both hemispheres	217.8
2697	Female, age 85, both hemispheres	173.0

Motor trigeminal nucleus
nTPM: 323.6

2309	Male, age 76, both hemispheres	518.3
2560	Male, age 74, both hemispheres	322.4
2335	Male, age 61, both hemispheres	282.6
2079	Male, age 80, both hemispheres	272.9
2321	Female, age 91, both hemispheres	222.0

Nuclei of the trapezoid body
nTPM: 381.2

2368	Female, age 91, both hemispheres	495.9
1983	Male, age 76, both hemispheres	462.6
2159	Male, age 61, both hemispheres	372.2
2735	Female, age 85, both hemispheres	322.5
2166	Male, age 80, both hemispheres	253.0

Nucleus raphe magnus
nTPM: 326.5

2051	Male, age 76, both hemispheres	443.3
2455	Male, age 74, both hemispheres	374.6
2160	Male, age 61, both hemispheres	330.2
2328	Male, age 80, both hemispheres	309.5
2459	Female, age 91, both hemispheres	306.4
2172	Female, age 85, both hemispheres	194.7

Paramedian reticular nucleus
nTPM: 381.8

2052	Male, age 76, both hemispheres	408.9
2313	Male, age 61, both hemispheres	407.6
2057	Male, age 80, both hemispheres	392.7
2050	Female, age 85, both hemispheres	318.0

Pedunculopontine tegmental nucleus
nTPM: 374.2

1921	Female, age 85, both hemispheres	521.5
2334	Male, age 80, both hemispheres	446.8
2338	Male, age 61, both hemispheres	154.1

Pontine nuclei
nTPM: 280.2

1863	Male, age 55, unknown	412.3
1968	Male, age 76, left hemisphere	405.6
2109	Female, age 72, unknown	278.0
2787	Female, age 85, both hemispheres	239.1
2115	Male, age 80, left hemisphere	236.9
2727	Male, age 61, right hemisphere	231.5
2319	Female, age 91, both hemispheres	227.3
2454	Male, age 74, left hemisphere	210.9

Pontine raphe nucleus
nTPM: 442.4

2853	Male, age 76, midline	551.5
2122	Female, age 85, midline	333.3

Posteroventral cochlear nucleus
nTPM: 386.4

2371	Male, age 61, both hemispheres	622.8
2070	Male, age 76, both hemispheres	416.3
2752	Female, age 85, both hemispheres	400.4
2341	Male, age 80, both hemispheres	300.3
2135	Female, age 91, both hemispheres	192.1

Principal sensory trigeminal nucleus
nTPM: 354.4

2324	Male, age 76, both hemispheres	659.4
2158	Male, age 61, both hemispheres	293.6
2008	Male, age 80, left hemisphere	274.0
2367	Female, age 91, left hemisphere	190.8

Reticular pontine nucleus, caudal
nTPM: 341.2

2092	Male, age 76, both hemispheres	452.8
2457	Female, age 91, both hemispheres	328.3
2332	Male, age 80, right hemisphere	322.2
2559	Male, age 74, both hemispheres	261.5

Reticular pontine nucleus, oral
nTPM: 372.7

2167	Male, age 76, both hemispheres	525.5
1939	Male, age 80, both hemispheres	507.8
2012	Female, age 85, both hemispheres	399.4
2366	Female, age 91, both hemispheres	239.4
2361	Male, age 74, both hemispheres	191.4

Reticulotegmental nucleus
nTPM: 487.4

2333	Male, age 80, both hemispheres	531.2
2322	Female, age 91, both hemispheres	514.2
2325	Male, age 76, both hemispheres	482.3
2452	Male, age 74, both hemispheres	421.7

Spinal trigeminal nucleus, oral
nTPM: 398.2

1978	Male, age 76, both hemispheres	463.7
2737	Female, age 85, both hemispheres	403.5
2164	Male, age 80, both hemispheres	327.3

Subcoeruleus area
nTPM: 423.8

2369	Female, age 85, left hemisphere	511.6
2451	Male, age 74, both hemispheres	452.2
1958	Male, age 80, both hemispheres	405.6
2323	Female, age 91, left hemisphere	402.3
2089	Male, age 76, left hemisphere	347.3

Superior olive
nTPM: 284.9

2020	Male, age 76, both hemispheres	324.5
2561	Female, age 91, both hemispheres	302.8
2364	Male, age 74, right hemisphere	287.2
2329	Male, age 80, right hemisphere	270.2
1875	Female, age 85, both hemispheres	240.0

Ventral periolivary nuclei
nTPM: 307.7

2130	Female, age 85, both hemispheres	375.9
2165	Male, age 80, both hemispheres	351.8
2023	Male, age 76, both hemispheres	286.2
2794	Female, age 91, left hemisphere	216.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 344.5

2456	Female, age 91, both hemispheres	410.2
1959	Male, age 76, both hemispheres	379.7
2840	Female, age 85, both hemispheres	373.8
2449	Male, age 74, both hemispheres	327.7
2161	Male, age 80, both hemispheres	306.7
2359	Male, age 61, both hemispheres	268.9

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1166.4

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1166.4

FF:10182-103D2	60 years, female	1681.4
FF:10165-103B3	76 years, female	651.4

Pons
Scaled Tags Per Million: 619.4

FF:10033-101E6

18-54 years, mixed

619.4

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	449.9

Pig sample

Sample description

nTPM

Pons
nTPM: 449.9

Samples: 3

Max nTPM: 486.9
Min nTPM: 407.5

Sample A	Female	486.9
Sample B	Female	407.5
Sample C	Male	455.4

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	462.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 462.8

Samples: 4

Max nTPM: 513.8
Min nTPM: 412.3

Sample A		412.3
Sample B		434.0
Sample C		513.8
Sample D		491.2

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	843.0

Rat sample

Sample description

nTPM

Pons
nTPM: 843.0

Samples: 4

Max nTPM: 876.6
Min nTPM: 787.5

Sample A		859.6
Sample A		848.2
Sample A		787.5
Sample A		876.6