Brain tissue expression of MSMO1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	143.3	nTPM
FANTOM5:	284.5	Scaled Tags Per Million

Macaque:	84.5	nTPM
Mouse:	50.4	nTPM
Rat:	135.6	nTPM
Pig:	127.4	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	143.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 126.9

2188	Female, age 91, both hemispheres	163.7
2301	Female, age 85, both hemispheres	156.6
2090	Male, age 80, both hemispheres	111.4
1984	Male, age 76, both hemispheres	75.9

Dorsal cochlear nucleus
nTPM: 103.0

2187	Female, age 91, both hemispheres	126.4
2802	Male, age 74, right hemisphere	122.3
2378	Male, age 80, both hemispheres	112.1
2058	Male, age 76, both hemispheres	86.3
2370	Male, age 61, both hemispheres	67.9

Dorsal tegmental nucleus
nTPM: 78.9

2326	Male, age 74, both hemispheres	113.6
1936	Male, age 76, left hemisphere	79.1
2083	Male, age 80, both hemispheres	71.5
2358	Male, age 61, both hemispheres	51.3

Dorsolateral tegmental area
nTPM: 72.1

2751	Female, age 85, both hemispheres	107.4
2360	Male, age 74, both hemispheres	84.8
2654	Male, age 80, both hemispheres	70.2
2141	Male, age 76, both hemispheres	68.8
2337	Male, age 61, both hemispheres	29.1

Kolliker-Fuse nucleus
nTPM: 89.6

2793	Female, age 91, left hemisphere	127.5
2315	Male, age 76, right hemisphere	71.9
2163	Male, age 80, both hemispheres	69.6

Lateral lemniscal nuclei
nTPM: 122.8

2453	Male, age 74, right hemisphere	152.8
2036	Male, age 80, both hemispheres	146.4
2320	Female, age 91, left hemisphere	140.0
2169	Male, age 76, both hemispheres	112.2
2746	Female, age 85, left hemisphere	62.5

Lateral parabrachial nucleus
nTPM: 89.9

2790	Male, age 61, both hemispheres	117.2
2792	Male, age 76, both hemispheres	100.2
2013	Male, age 80, both hemispheres	78.7
2139	Female, age 85, right hemisphere	63.4

Lateral vestibular nucleus
nTPM: 97.5

2311	Male, age 80, both hemispheres	125.8
2184	Male, age 76, both hemispheres	69.3

Locus coeruleus
nTPM: 120.6

2014	Male, age 55, unknown	150.1
2720	Male, age 74, both hemispheres	132.3
2123	Female, age 91, both hemispheres	129.7
2317	Female, age 72, unknown	120.2
2162	Male, age 80, both hemispheres	104.4
1980	Male, age 76, both hemispheres	104.1
2788	Male, age 74, unknown	103.1

Medial parabrachial nucleus
nTPM: 88.3

2170	Female, age 91, both hemispheres	121.6
2854	Male, age 80, both hemispheres	87.4
2463	Female, age 85, right hemisphere	85.2
2156	Male, age 61, both hemispheres	75.2
2786	Male, age 76, both hemispheres	72.0

Medial periolivary nuclei
nTPM: 120.5

2791	Male, age 74, right hemisphere	210.3
2458	Female, age 91, both hemispheres	124.9
2171	Female, age 85, both hemispheres	105.5
2063	Male, age 76, both hemispheres	105.4
2081	Male, age 80, both hemispheres	56.5

Motor facial nucleus
nTPM: 137.8

2365	Male, age 74, right hemisphere	205.2
2795	Female, age 91, both hemispheres	195.5
2327	Male, age 80, both hemispheres	136.4
2062	Male, age 76, both hemispheres	103.0
2126	Male, age 61, both hemispheres	100.1
2697	Female, age 85, both hemispheres	86.9

Motor trigeminal nucleus
nTPM: 102.2

2560	Male, age 74, both hemispheres	161.6
2079	Male, age 80, both hemispheres	112.8
2321	Female, age 91, both hemispheres	108.2
2309	Male, age 76, both hemispheres	64.8
2335	Male, age 61, both hemispheres	63.4

Nuclei of the trapezoid body
nTPM: 143.3

2368	Female, age 91, both hemispheres	194.8
2159	Male, age 61, both hemispheres	157.8
2735	Female, age 85, both hemispheres	156.8
1983	Male, age 76, both hemispheres	110.0
2166	Male, age 80, both hemispheres	97.1

Nucleus raphe magnus
nTPM: 134.9

2160	Male, age 61, both hemispheres	200.7
2455	Male, age 74, both hemispheres	186.6
2459	Female, age 91, both hemispheres	135.3
2328	Male, age 80, both hemispheres	123.2
2172	Female, age 85, both hemispheres	112.2
2051	Male, age 76, both hemispheres	51.5

Paramedian reticular nucleus
nTPM: 117.3

2313	Male, age 61, both hemispheres	128.5
2057	Male, age 80, both hemispheres	122.4
2052	Male, age 76, both hemispheres	111.1
2050	Female, age 85, both hemispheres	107.4

Pedunculopontine tegmental nucleus
nTPM: 79.0

2334	Male, age 80, both hemispheres	93.3
1921	Female, age 85, both hemispheres	88.1
2338	Male, age 61, both hemispheres	55.5

Pontine nuclei
nTPM: 107.6

2727	Male, age 61, right hemisphere	192.4
2454	Male, age 74, left hemisphere	122.3
2319	Female, age 91, both hemispheres	117.3
1863	Male, age 55, unknown	114.3
2787	Female, age 85, both hemispheres	101.0
1968	Male, age 76, left hemisphere	87.5
2109	Female, age 72, unknown	85.7
2115	Male, age 80, left hemisphere	39.9

Pontine raphe nucleus
nTPM: 108.3

2122	Female, age 85, midline	130.7
2853	Male, age 76, midline	85.8

Posteroventral cochlear nucleus
nTPM: 110.2

2341	Male, age 80, both hemispheres	165.6
2135	Female, age 91, both hemispheres	120.3
2070	Male, age 76, both hemispheres	92.6
2752	Female, age 85, both hemispheres	88.7
2371	Male, age 61, both hemispheres	83.9

Principal sensory trigeminal nucleus
nTPM: 121.7

2158	Male, age 61, both hemispheres	180.3
2008	Male, age 80, left hemisphere	134.5
2367	Female, age 91, left hemisphere	96.4
2324	Male, age 76, both hemispheres	75.5

Reticular pontine nucleus, caudal
nTPM: 122.7

2457	Female, age 91, both hemispheres	183.3
2332	Male, age 80, right hemisphere	132.4
2092	Male, age 76, both hemispheres	97.6
2559	Male, age 74, both hemispheres	77.4

Reticular pontine nucleus, oral
nTPM: 105.7

2366	Female, age 91, both hemispheres	146.4
2361	Male, age 74, both hemispheres	140.9
2012	Female, age 85, both hemispheres	100.7
2167	Male, age 76, both hemispheres	70.6
1939	Male, age 80, both hemispheres	70.0

Reticulotegmental nucleus
nTPM: 97.1

2322	Female, age 91, both hemispheres	136.2
2452	Male, age 74, both hemispheres	92.1
2333	Male, age 80, both hemispheres	82.2
2325	Male, age 76, both hemispheres	78.0

Spinal trigeminal nucleus, oral
nTPM: 78.3

2164	Male, age 80, both hemispheres	85.4
2737	Female, age 85, both hemispheres	79.3
1978	Male, age 76, both hemispheres	70.1

Subcoeruleus area
nTPM: 87.2

2369	Female, age 85, left hemisphere	97.2
2089	Male, age 76, left hemisphere	95.8
1958	Male, age 80, both hemispheres	94.0
2323	Female, age 91, left hemisphere	80.4
2451	Male, age 74, both hemispheres	68.6

Superior olive
nTPM: 129.0

2364	Male, age 74, right hemisphere	208.3
1875	Female, age 85, both hemispheres	125.7
2561	Female, age 91, both hemispheres	110.8
2020	Male, age 76, both hemispheres	100.8
2329	Male, age 80, right hemisphere	99.4

Ventral periolivary nuclei
nTPM: 120.0

2130	Female, age 85, both hemispheres	130.6
2165	Male, age 80, both hemispheres	127.9
2794	Female, age 91, left hemisphere	112.4
2023	Male, age 76, both hemispheres	109.1

Ventrolateral tegmental area, A5 NE cell group
nTPM: 109.8

2456	Female, age 91, both hemispheres	154.9
2449	Male, age 74, both hemispheres	145.8
1959	Male, age 76, both hemispheres	95.3
2161	Male, age 80, both hemispheres	94.7
2840	Female, age 85, both hemispheres	92.5
2359	Male, age 61, both hemispheres	75.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	284.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 155.6

FF:10182-103D2	60 years, female	169.8
FF:10165-103B3	76 years, female	141.4

Pons
Scaled Tags Per Million: 284.5

FF:10033-101E6

18-54 years, mixed

284.5

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	84.5

Macaque sample

Sample description

nTPM

Pons
nTPM: 84.5

Samples: 2

Max nTPM: 112.0
Min nTPM: 56.9

Sample A		112.0
Sample B		56.9

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	127.4

Pig sample

Sample description

nTPM

Pons
nTPM: 127.3

Samples: 3

Max nTPM: 170.6
Min nTPM: 90.2

Sample A	Female	90.2
Sample B	Female	121.2
Sample C	Male	170.6

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	50.4

Mouse sample

Sample description

nTPM

Pons
nTPM: 50.4

Samples: 4

Max nTPM: 57.8
Min nTPM: 40.0

Sample A		54.9
Sample B		40.0
Sample C		57.8
Sample D		48.8

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	135.6

Rat sample

Sample description

nTPM

Pons
nTPM: 135.7

Samples: 4

Max nTPM: 144.5
Min nTPM: 122.9

Sample A		122.9
Sample A		133.6
Sample A		141.6
Sample A		144.5