Single cell type - BORCS8-MEF2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BORCS8-MEF2B
Gene descriptionⁱ Full gene name according to HGNC.	BORCS8-MEF2B readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Distal convoluted tubule cells, Podocytes, Proximal tubule cells, Renal connecting tubule cells, Loop of henle epithelial cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Papillary tip epithelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.95
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Group enriched (Renal nephron cells, Ductal cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

BORCS8-MEF2B is part of cluster 105 Non-specific - Mixed function with confidenceⁱ 1
131 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRIT1	KRIT1 ankyrin repeat containing	0.9154	105
WDR27	WD repeat domain 27	0.9071	105
ENSG00000254692	Novel protein	0.8523	105
LINC02210-CRHR1	LINC02210-CRHR1 readthrough	0.8401	105
UMAD1	UBAP1-MVB12-associated (UMA) domain containing 1	0.8397	105
ANAPC10	Anaphase promoting complex subunit 10	0.8305	105
GPRASP1	G protein-coupled receptor associated sorting protein 1	0.8193	105
NPIPB12	Nuclear pore complex interacting protein family member B12	0.7950	105
NAIP	NLR family apoptosis inhibitory protein	0.7942	105
CCDC180	Coiled-coil domain containing 180	0.7939	105
NPIPB5	Nuclear pore complex interacting protein family member B5	0.7879	105
ENSG00000281039	Novel protein	0.7601	105
RBAK-RBAKDN	RBAK-RBAKDN readthrough	0.7579	105
ZNF512	Zinc finger protein 512	0.7504	105
SOCS5	Suppressor of cytokine signaling 5	0.7456	105

IMMUNE CELLS

BORCS8-MEF2B is part of cluster 19 Eosinophils - Unknown function with confidenceⁱ 1
83 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19
NECTIN2	Nectin cell adhesion molecule 2	1.0000	19
PPDPF	Pancreatic progenitor cell differentiation and proliferation factor	1.0000	19
SEMG1	Semenogelin 1	1.0000	19
GPSM2	G protein signaling modulator 2	1.0000	19
TMIGD3	Transmembrane and immunoglobulin domain containing 3	1.0000	19
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1.0000	19
RXYLT1	Ribitol xylosyltransferase 1	1.0000	19
WAS	WASP actin nucleation promoting factor	1.0000	19
FKBP8	FKBP prolyl isomerase 8	1.0000	19
PRSS33	Serine protease 33	1.0000	19
RENBP	Renin binding protein	1.0000	19
CEBPE	CCAAT enhancer binding protein epsilon	1.0000	19