Brain tissue expression of BCAS1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	1002.5	nTPM
FANTOM5:	860.8	Scaled Tags Per Million

Macaque:	302.6	nTPM
Mouse:	335.8	nTPM
Rat:	256.3	nTPM
Pig:	476.1	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1002.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 946.4

2301	Female, age 85, both hemispheres	1221.4
2188	Female, age 91, both hemispheres	1205.1
2090	Male, age 80, both hemispheres	875.7
1984	Male, age 76, both hemispheres	483.4

Dorsal cochlear nucleus
nTPM: 809.9

2802	Male, age 74, right hemisphere	900.4
2187	Female, age 91, both hemispheres	891.7
2378	Male, age 80, both hemispheres	839.8
2370	Male, age 61, both hemispheres	738.2
2058	Male, age 76, both hemispheres	679.6

Dorsal tegmental nucleus
nTPM: 727.0

2083	Male, age 80, both hemispheres	904.4
2326	Male, age 74, both hemispheres	713.2
1936	Male, age 76, left hemisphere	659.3
2358	Male, age 61, both hemispheres	631.0

Dorsolateral tegmental area
nTPM: 634.9

2654	Male, age 80, both hemispheres	911.9
2751	Female, age 85, both hemispheres	854.3
2337	Male, age 61, both hemispheres	697.5
2360	Male, age 74, both hemispheres	370.3
2141	Male, age 76, both hemispheres	340.4

Kolliker-Fuse nucleus
nTPM: 798.2

2793	Female, age 91, left hemisphere	1249.6
2163	Male, age 80, both hemispheres	774.1
2315	Male, age 76, right hemisphere	371.0

Lateral lemniscal nuclei
nTPM: 663.6

2320	Female, age 91, left hemisphere	821.4
2453	Male, age 74, right hemisphere	718.1
2169	Male, age 76, both hemispheres	672.7
2036	Male, age 80, both hemispheres	624.4
2746	Female, age 85, left hemisphere	481.4

Lateral parabrachial nucleus
nTPM: 681.6

2792	Male, age 76, both hemispheres	1084.9
2013	Male, age 80, both hemispheres	650.0
2790	Male, age 61, both hemispheres	620.7
2139	Female, age 85, right hemisphere	370.7

Lateral vestibular nucleus
nTPM: 856.2

2311	Male, age 80, both hemispheres	960.3
2184	Male, age 76, both hemispheres	752.0

Locus coeruleus
nTPM: 329.9

2720	Male, age 74, both hemispheres	660.5
2162	Male, age 80, both hemispheres	442.0
2788	Male, age 74, unknown	281.6
2317	Female, age 72, unknown	267.0
2123	Female, age 91, both hemispheres	262.3
2014	Male, age 55, unknown	224.2
1980	Male, age 76, both hemispheres	171.8

Medial parabrachial nucleus
nTPM: 830.2

2170	Female, age 91, both hemispheres	1013.0
2854	Male, age 80, both hemispheres	820.7
2463	Female, age 85, right hemisphere	815.2
2786	Male, age 76, both hemispheres	800.5
2156	Male, age 61, both hemispheres	701.6

Medial periolivary nuclei
nTPM: 701.0

2458	Female, age 91, both hemispheres	1069.9
2081	Male, age 80, both hemispheres	822.0
2063	Male, age 76, both hemispheres	614.7
2171	Female, age 85, both hemispheres	584.3
2791	Male, age 74, right hemisphere	414.1

Motor facial nucleus
nTPM: 817.6

2697	Female, age 85, both hemispheres	1163.3
2327	Male, age 80, both hemispheres	961.1
2795	Female, age 91, both hemispheres	921.0
2126	Male, age 61, both hemispheres	828.9
2365	Male, age 74, right hemisphere	535.7
2062	Male, age 76, both hemispheres	495.6

Motor trigeminal nucleus
nTPM: 839.5

2321	Female, age 91, both hemispheres	1116.1
2309	Male, age 76, both hemispheres	891.5
2079	Male, age 80, both hemispheres	794.8
2560	Male, age 74, both hemispheres	702.3
2335	Male, age 61, both hemispheres	692.9

Nuclei of the trapezoid body
nTPM: 706.5

2166	Male, age 80, both hemispheres	1027.9
2368	Female, age 91, both hemispheres	843.2
2159	Male, age 61, both hemispheres	630.9
1983	Male, age 76, both hemispheres	569.3
2735	Female, age 85, both hemispheres	461.1

Nucleus raphe magnus
nTPM: 670.8

2328	Male, age 80, both hemispheres	941.0
2459	Female, age 91, both hemispheres	863.0
2051	Male, age 76, both hemispheres	772.4
2172	Female, age 85, both hemispheres	542.1
2455	Male, age 74, both hemispheres	526.3
2160	Male, age 61, both hemispheres	380.1

Paramedian reticular nucleus
nTPM: 854.7

2052	Male, age 76, both hemispheres	1399.8
2057	Male, age 80, both hemispheres	717.7
2050	Female, age 85, both hemispheres	677.8
2313	Male, age 61, both hemispheres	623.3

Pedunculopontine tegmental nucleus
nTPM: 602.3

2338	Male, age 61, both hemispheres	701.7
2334	Male, age 80, both hemispheres	675.7
1921	Female, age 85, both hemispheres	429.4

Pontine nuclei
nTPM: 678.5

2319	Female, age 91, both hemispheres	1034.7
1968	Male, age 76, left hemisphere	826.5
2115	Male, age 80, left hemisphere	784.1
2454	Male, age 74, left hemisphere	663.8
1863	Male, age 55, unknown	603.4
2787	Female, age 85, both hemispheres	571.7
2109	Female, age 72, unknown	565.7
2727	Male, age 61, right hemisphere	377.8

Pontine raphe nucleus
nTPM: 481.2

2122	Female, age 85, midline	576.8
2853	Male, age 76, midline	385.5

Posteroventral cochlear nucleus
nTPM: 1002.5

2341	Male, age 80, both hemispheres	1508.3
2135	Female, age 91, both hemispheres	1293.9
2371	Male, age 61, both hemispheres	861.7
2070	Male, age 76, both hemispheres	781.8
2752	Female, age 85, both hemispheres	567.1

Principal sensory trigeminal nucleus
nTPM: 688.5

2367	Female, age 91, left hemisphere	956.8
2324	Male, age 76, both hemispheres	774.7
2008	Male, age 80, left hemisphere	538.4
2158	Male, age 61, both hemispheres	484.2

Reticular pontine nucleus, caudal
nTPM: 898.5

2457	Female, age 91, both hemispheres	1175.0
2332	Male, age 80, right hemisphere	879.3
2092	Male, age 76, both hemispheres	780.2
2559	Male, age 74, both hemispheres	759.6

Reticular pontine nucleus, oral
nTPM: 785.4

2366	Female, age 91, both hemispheres	1230.1
1939	Male, age 80, both hemispheres	729.2
2167	Male, age 76, both hemispheres	720.6
2361	Male, age 74, both hemispheres	645.3
2012	Female, age 85, both hemispheres	601.7

Reticulotegmental nucleus
nTPM: 883.2

2322	Female, age 91, both hemispheres	1154.2
2333	Male, age 80, both hemispheres	925.2
2452	Male, age 74, both hemispheres	816.0
2325	Male, age 76, both hemispheres	637.3

Spinal trigeminal nucleus, oral
nTPM: 651.8

2164	Male, age 80, both hemispheres	933.8
1978	Male, age 76, both hemispheres	588.1
2737	Female, age 85, both hemispheres	433.3

Subcoeruleus area
nTPM: 699.5

2369	Female, age 85, left hemisphere	988.4
2089	Male, age 76, left hemisphere	707.9
1958	Male, age 80, both hemispheres	698.6
2451	Male, age 74, both hemispheres	645.8
2323	Female, age 91, left hemisphere	456.8

Superior olive
nTPM: 785.9

2561	Female, age 91, both hemispheres	1051.4
2020	Male, age 76, both hemispheres	1041.4
2329	Male, age 80, right hemisphere	910.4
1875	Female, age 85, both hemispheres	527.7
2364	Male, age 74, right hemisphere	398.4

Ventral periolivary nuclei
nTPM: 782.5

2023	Male, age 76, both hemispheres	937.7
2794	Female, age 91, left hemisphere	896.3
2165	Male, age 80, both hemispheres	848.0
2130	Female, age 85, both hemispheres	447.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 705.5

2456	Female, age 91, both hemispheres	880.0
2161	Male, age 80, both hemispheres	782.6
2840	Female, age 85, both hemispheres	736.1
1959	Male, age 76, both hemispheres	730.3
2359	Male, age 61, both hemispheres	555.7
2449	Male, age 74, both hemispheres	548.0

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	860.8

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 860.8

FF:10182-103D2	60 years, female	1227.5
FF:10165-103B3	76 years, female	494.2

Pons
Scaled Tags Per Million: 832.4

FF:10033-101E6

18-54 years, mixed

832.4

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	302.6

Macaque sample

Sample description

nTPM

Pons
nTPM: 302.7

Samples: 2

Max nTPM: 315.9
Min nTPM: 289.4

Sample A		315.9
Sample B		289.4

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	476.1

Pig sample

Sample description

nTPM

Pons
nTPM: 476.1

Samples: 3

Max nTPM: 729.9
Min nTPM: 332.3

Sample A	Female	332.3
Sample B	Female	366.1
Sample C	Male	729.9

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	335.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 335.8

Samples: 4

Max nTPM: 395.9
Min nTPM: 267.4

Sample A		395.9
Sample B		267.4
Sample C		357.2
Sample D		322.7

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	256.3

Rat sample

Sample description

nTPM

Pons
nTPM: 256.3

Samples: 4

Max nTPM: 276.9
Min nTPM: 228.1

Sample A		276.9
Sample A		250.4
Sample A		228.1
Sample A		269.7