Brain tissue expression of ELOVL1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	134.7	nTPM
FANTOM5:	195.8	Scaled Tags Per Million

Mouse:	29.0	nTPM
Rat:	101.5	nTPM
Pig:	56.2	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	134.7

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 133.7

2188	Female, age 91, both hemispheres	157.7
2090	Male, age 80, both hemispheres	154.7
2301	Female, age 85, both hemispheres	139.5
1984	Male, age 76, both hemispheres	82.9

Dorsal cochlear nucleus
nTPM: 107.0

2187	Female, age 91, both hemispheres	134.6
2378	Male, age 80, both hemispheres	118.3
2370	Male, age 61, both hemispheres	98.9
2802	Male, age 74, right hemisphere	96.1
2058	Male, age 76, both hemispheres	87.3

Dorsal tegmental nucleus
nTPM: 98.1

2083	Male, age 80, both hemispheres	137.2
2326	Male, age 74, both hemispheres	95.5
2358	Male, age 61, both hemispheres	83.7
1936	Male, age 76, left hemisphere	76.1

Dorsolateral tegmental area
nTPM: 108.3

2751	Female, age 85, both hemispheres	175.0
2337	Male, age 61, both hemispheres	126.9
2654	Male, age 80, both hemispheres	125.9
2360	Male, age 74, both hemispheres	63.9
2141	Male, age 76, both hemispheres	50.0

Kolliker-Fuse nucleus
nTPM: 111.6

2793	Female, age 91, left hemisphere	160.2
2163	Male, age 80, both hemispheres	94.3
2315	Male, age 76, right hemisphere	80.4

Lateral lemniscal nuclei
nTPM: 103.2

2320	Female, age 91, left hemisphere	127.7
2036	Male, age 80, both hemispheres	107.5
2746	Female, age 85, left hemisphere	102.3
2169	Male, age 76, both hemispheres	93.9
2453	Male, age 74, right hemisphere	84.8

Lateral parabrachial nucleus
nTPM: 134.7

2792	Male, age 76, both hemispheres	196.9
2790	Male, age 61, both hemispheres	132.5
2013	Male, age 80, both hemispheres	125.0
2139	Female, age 85, right hemisphere	84.5

Lateral vestibular nucleus
nTPM: 109.4

2311	Male, age 80, both hemispheres	128.8
2184	Male, age 76, both hemispheres	89.9

Locus coeruleus
nTPM: 50.9

2162	Male, age 80, both hemispheres	70.0
2720	Male, age 74, both hemispheres	61.0
2123	Female, age 91, both hemispheres	52.2
2317	Female, age 72, unknown	51.9
2788	Male, age 74, unknown	47.1
2014	Male, age 55, unknown	41.3
1980	Male, age 76, both hemispheres	32.7

Medial parabrachial nucleus
nTPM: 123.8

2170	Female, age 91, both hemispheres	159.8
2463	Female, age 85, right hemisphere	137.6
2854	Male, age 80, both hemispheres	124.0
2786	Male, age 76, both hemispheres	100.0
2156	Male, age 61, both hemispheres	97.7

Medial periolivary nuclei
nTPM: 108.4

2791	Male, age 74, right hemisphere	137.4
2081	Male, age 80, both hemispheres	120.7
2063	Male, age 76, both hemispheres	111.3
2458	Female, age 91, both hemispheres	111.0
2171	Female, age 85, both hemispheres	61.8

Motor facial nucleus
nTPM: 111.6

2126	Male, age 61, both hemispheres	144.2
2365	Male, age 74, right hemisphere	143.4
2697	Female, age 85, both hemispheres	121.0
2795	Female, age 91, both hemispheres	102.8
2062	Male, age 76, both hemispheres	84.5
2327	Male, age 80, both hemispheres	73.9

Motor trigeminal nucleus
nTPM: 98.4

2560	Male, age 74, both hemispheres	119.2
2321	Female, age 91, both hemispheres	105.2
2309	Male, age 76, both hemispheres	94.8
2079	Male, age 80, both hemispheres	90.6
2335	Male, age 61, both hemispheres	82.0

Nuclei of the trapezoid body
nTPM: 90.0

2368	Female, age 91, both hemispheres	110.6
2166	Male, age 80, both hemispheres	109.7
1983	Male, age 76, both hemispheres	96.3
2159	Male, age 61, both hemispheres	79.0
2735	Female, age 85, both hemispheres	54.4

Nucleus raphe magnus
nTPM: 83.6

2051	Male, age 76, both hemispheres	113.0
2459	Female, age 91, both hemispheres	109.8
2328	Male, age 80, both hemispheres	99.0
2455	Male, age 74, both hemispheres	90.6
2160	Male, age 61, both hemispheres	49.0
2172	Female, age 85, both hemispheres	40.1

Paramedian reticular nucleus
nTPM: 108.1

2052	Male, age 76, both hemispheres	127.0
2057	Male, age 80, both hemispheres	126.9
2050	Female, age 85, both hemispheres	97.0
2313	Male, age 61, both hemispheres	81.4

Pedunculopontine tegmental nucleus
nTPM: 95.0

2338	Male, age 61, both hemispheres	110.5
2334	Male, age 80, both hemispheres	96.9
1921	Female, age 85, both hemispheres	77.7

Pontine nuclei
nTPM: 118.6

2454	Male, age 74, left hemisphere	168.5
2109	Female, age 72, unknown	146.9
2319	Female, age 91, both hemispheres	142.0
1863	Male, age 55, unknown	125.7
1968	Male, age 76, left hemisphere	112.9
2115	Male, age 80, left hemisphere	106.7
2727	Male, age 61, right hemisphere	73.6
2787	Female, age 85, both hemispheres	72.6

Pontine raphe nucleus
nTPM: 71.6

2853	Male, age 76, midline	72.2
2122	Female, age 85, midline	71.0

Posteroventral cochlear nucleus
nTPM: 132.6

2341	Male, age 80, both hemispheres	173.2
2135	Female, age 91, both hemispheres	173.1
2070	Male, age 76, both hemispheres	134.5
2371	Male, age 61, both hemispheres	106.3
2752	Female, age 85, both hemispheres	75.9

Principal sensory trigeminal nucleus
nTPM: 90.5

2367	Female, age 91, left hemisphere	144.0
2008	Male, age 80, left hemisphere	76.4
2324	Male, age 76, both hemispheres	75.6
2158	Male, age 61, both hemispheres	65.8

Reticular pontine nucleus, caudal
nTPM: 122.5

2559	Male, age 74, both hemispheres	145.3
2092	Male, age 76, both hemispheres	137.5
2457	Female, age 91, both hemispheres	136.8
2332	Male, age 80, right hemisphere	70.4

Reticular pontine nucleus, oral
nTPM: 132.4

2361	Male, age 74, both hemispheres	154.4
2366	Female, age 91, both hemispheres	150.1
1939	Male, age 80, both hemispheres	128.4
2167	Male, age 76, both hemispheres	118.0
2012	Female, age 85, both hemispheres	111.3

Reticulotegmental nucleus
nTPM: 80.5

2322	Female, age 91, both hemispheres	94.5
2333	Male, age 80, both hemispheres	88.7
2452	Male, age 74, both hemispheres	84.9
2325	Male, age 76, both hemispheres	53.9

Spinal trigeminal nucleus, oral
nTPM: 90.2

2164	Male, age 80, both hemispheres	108.1
1978	Male, age 76, both hemispheres	93.3
2737	Female, age 85, both hemispheres	69.2

Subcoeruleus area
nTPM: 106.1

2369	Female, age 85, left hemisphere	201.5
2089	Male, age 76, left hemisphere	99.1
1958	Male, age 80, both hemispheres	97.1
2323	Female, age 91, left hemisphere	66.4
2451	Male, age 74, both hemispheres	66.2

Superior olive
nTPM: 118.2

2020	Male, age 76, both hemispheres	148.5
2364	Male, age 74, right hemisphere	143.8
2329	Male, age 80, right hemisphere	103.1
2561	Female, age 91, both hemispheres	99.6
1875	Female, age 85, both hemispheres	96.3

Ventral periolivary nuclei
nTPM: 101.6

2023	Male, age 76, both hemispheres	171.0
2165	Male, age 80, both hemispheres	95.6
2794	Female, age 91, left hemisphere	74.7
2130	Female, age 85, both hemispheres	65.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 114.9

2456	Female, age 91, both hemispheres	126.9
1959	Male, age 76, both hemispheres	125.9
2359	Male, age 61, both hemispheres	122.4
2840	Female, age 85, both hemispheres	114.7
2161	Male, age 80, both hemispheres	103.1
2449	Male, age 74, both hemispheres	96.2

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	195.8

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 154.9

FF:10182-103D2	60 years, female	160.2
FF:10165-103B3	76 years, female	149.6

Pons
Scaled Tags Per Million: 195.8

FF:10033-101E6

18-54 years, mixed

195.8

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	56.2

Pig sample

Sample description

nTPM

Pons
nTPM: 56.2

Samples: 3

Max nTPM: 67.0
Min nTPM: 48.9

Sample A	Female	52.7
Sample B	Female	48.9
Sample C	Male	67.0

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	29.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 29.0

Samples: 4

Max nTPM: 31.8
Min nTPM: 26.8

Sample A		31.8
Sample B		27.8
Sample C		29.7
Sample D		26.8

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	101.5

Rat sample

Sample description

nTPM

Pons
nTPM: 101.5

Samples: 4

Max nTPM: 112.3
Min nTPM: 90.6

Sample A		98.5
Sample A		90.6
Sample A		112.3
Sample A		104.6