Brain tissue expression of CD59 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	358.9	nTPM
FANTOM5:	289.7	Scaled Tags Per Million

Rat:	154.6	nTPM
Pig:	95.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	358.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 235.2

2090	Male, age 80, both hemispheres	255.6
2301	Female, age 85, both hemispheres	230.1
1984	Male, age 76, both hemispheres	229.7
2188	Female, age 91, both hemispheres	225.3

Dorsal cochlear nucleus
nTPM: 307.5

2802	Male, age 74, right hemisphere	350.1
2378	Male, age 80, both hemispheres	337.1
2058	Male, age 76, both hemispheres	310.3
2370	Male, age 61, both hemispheres	282.4
2187	Female, age 91, both hemispheres	257.4

Dorsal tegmental nucleus
nTPM: 317.4

2083	Male, age 80, both hemispheres	344.7
2358	Male, age 61, both hemispheres	341.2
2326	Male, age 74, both hemispheres	295.5
1936	Male, age 76, left hemisphere	288.2

Dorsolateral tegmental area
nTPM: 309.6

2654	Male, age 80, both hemispheres	343.4
2337	Male, age 61, both hemispheres	323.1
2751	Female, age 85, both hemispheres	305.6
2360	Male, age 74, both hemispheres	300.0
2141	Male, age 76, both hemispheres	275.7

Kolliker-Fuse nucleus
nTPM: 298.1

2163	Male, age 80, both hemispheres	410.5
2315	Male, age 76, right hemisphere	275.3
2793	Female, age 91, left hemisphere	208.5

Lateral lemniscal nuclei
nTPM: 262.2

2036	Male, age 80, both hemispheres	310.4
2169	Male, age 76, both hemispheres	296.2
2746	Female, age 85, left hemisphere	269.7
2453	Male, age 74, right hemisphere	240.6
2320	Female, age 91, left hemisphere	194.1

Lateral parabrachial nucleus
nTPM: 287.0

2139	Female, age 85, right hemisphere	326.2
2790	Male, age 61, both hemispheres	300.5
2013	Male, age 80, both hemispheres	275.5
2792	Male, age 76, both hemispheres	245.6

Lateral vestibular nucleus
nTPM: 295.1

2184	Male, age 76, both hemispheres	349.2
2311	Male, age 80, both hemispheres	241.0

Locus coeruleus
nTPM: 358.9

2014	Male, age 55, unknown	436.3
2788	Male, age 74, unknown	410.5
2123	Female, age 91, both hemispheres	393.5
2317	Female, age 72, unknown	356.6
1980	Male, age 76, both hemispheres	351.7
2162	Male, age 80, both hemispheres	290.8
2720	Male, age 74, both hemispheres	272.7

Medial parabrachial nucleus
nTPM: 287.3

2156	Male, age 61, both hemispheres	338.2
2786	Male, age 76, both hemispheres	290.1
2170	Female, age 91, both hemispheres	288.3
2854	Male, age 80, both hemispheres	271.9
2463	Female, age 85, right hemisphere	248.2

Medial periolivary nuclei
nTPM: 282.1

2171	Female, age 85, both hemispheres	355.1
2063	Male, age 76, both hemispheres	337.4
2791	Male, age 74, right hemisphere	271.4
2081	Male, age 80, both hemispheres	232.3
2458	Female, age 91, both hemispheres	214.4

Motor facial nucleus
nTPM: 266.7

2062	Male, age 76, both hemispheres	340.3
2795	Female, age 91, both hemispheres	332.5
2365	Male, age 74, right hemisphere	259.5
2126	Male, age 61, both hemispheres	234.2
2697	Female, age 85, both hemispheres	218.9
2327	Male, age 80, both hemispheres	214.5

Motor trigeminal nucleus
nTPM: 239.6

2309	Male, age 76, both hemispheres	299.0
2079	Male, age 80, both hemispheres	240.3
2335	Male, age 61, both hemispheres	238.9
2560	Male, age 74, both hemispheres	220.4
2321	Female, age 91, both hemispheres	199.2

Nuclei of the trapezoid body
nTPM: 285.6

2735	Female, age 85, both hemispheres	332.7
1983	Male, age 76, both hemispheres	319.7
2159	Male, age 61, both hemispheres	277.8
2368	Female, age 91, both hemispheres	249.1
2166	Male, age 80, both hemispheres	248.7

Nucleus raphe magnus
nTPM: 285.8

2172	Female, age 85, both hemispheres	331.4
2160	Male, age 61, both hemispheres	315.0
2051	Male, age 76, both hemispheres	308.3
2328	Male, age 80, both hemispheres	255.6
2455	Male, age 74, both hemispheres	255.3
2459	Female, age 91, both hemispheres	249.0

Paramedian reticular nucleus
nTPM: 317.6

2050	Female, age 85, both hemispheres	358.9
2052	Male, age 76, both hemispheres	326.9
2057	Male, age 80, both hemispheres	326.9
2313	Male, age 61, both hemispheres	257.9

Pedunculopontine tegmental nucleus
nTPM: 322.2

2338	Male, age 61, both hemispheres	335.5
2334	Male, age 80, both hemispheres	331.0
1921	Female, age 85, both hemispheres	300.1

Pontine nuclei
nTPM: 281.6

1863	Male, age 55, unknown	344.4
2787	Female, age 85, both hemispheres	340.3
2109	Female, age 72, unknown	313.3
2727	Male, age 61, right hemisphere	304.8
1968	Male, age 76, left hemisphere	299.0
2115	Male, age 80, left hemisphere	234.2
2454	Male, age 74, left hemisphere	210.4
2319	Female, age 91, both hemispheres	206.4

Pontine raphe nucleus
nTPM: 307.4

2122	Female, age 85, midline	310.6
2853	Male, age 76, midline	304.1

Posteroventral cochlear nucleus
nTPM: 269.0

2752	Female, age 85, both hemispheres	316.0
2341	Male, age 80, both hemispheres	278.4
2070	Male, age 76, both hemispheres	277.3
2371	Male, age 61, both hemispheres	274.7
2135	Female, age 91, both hemispheres	198.7

Principal sensory trigeminal nucleus
nTPM: 269.2

2324	Male, age 76, both hemispheres	331.4
2158	Male, age 61, both hemispheres	283.4
2008	Male, age 80, left hemisphere	261.7
2367	Female, age 91, left hemisphere	200.2

Reticular pontine nucleus, caudal
nTPM: 235.1

2092	Male, age 76, both hemispheres	283.5
2332	Male, age 80, right hemisphere	225.5
2457	Female, age 91, both hemispheres	218.1
2559	Male, age 74, both hemispheres	213.4

Reticular pontine nucleus, oral
nTPM: 267.0

1939	Male, age 80, both hemispheres	354.9
2167	Male, age 76, both hemispheres	313.8
2012	Female, age 85, both hemispheres	293.9
2361	Male, age 74, both hemispheres	188.3
2366	Female, age 91, both hemispheres	183.9

Reticulotegmental nucleus
nTPM: 281.9

2333	Male, age 80, both hemispheres	294.8
2325	Male, age 76, both hemispheres	289.2
2322	Female, age 91, both hemispheres	284.3
2452	Male, age 74, both hemispheres	259.1

Spinal trigeminal nucleus, oral
nTPM: 298.0

2164	Male, age 80, both hemispheres	339.3
2737	Female, age 85, both hemispheres	331.9
1978	Male, age 76, both hemispheres	222.9

Subcoeruleus area
nTPM: 267.5

2323	Female, age 91, left hemisphere	290.6
1958	Male, age 80, both hemispheres	288.4
2369	Female, age 85, left hemisphere	282.2
2451	Male, age 74, both hemispheres	250.9
2089	Male, age 76, left hemisphere	225.5

Superior olive
nTPM: 265.3

1875	Female, age 85, both hemispheres	306.9
2020	Male, age 76, both hemispheres	282.4
2364	Male, age 74, right hemisphere	273.3
2329	Male, age 80, right hemisphere	236.7
2561	Female, age 91, both hemispheres	227.5

Ventral periolivary nuclei
nTPM: 295.4

2130	Female, age 85, both hemispheres	359.7
2023	Male, age 76, both hemispheres	292.7
2165	Male, age 80, both hemispheres	289.6
2794	Female, age 91, left hemisphere	239.4

Ventrolateral tegmental area, A5 NE cell group
nTPM: 284.1

2359	Male, age 61, both hemispheres	348.2
2840	Female, age 85, both hemispheres	319.1
2161	Male, age 80, both hemispheres	272.6
1959	Male, age 76, both hemispheres	265.0
2456	Female, age 91, both hemispheres	263.5
2449	Male, age 74, both hemispheres	236.6

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	289.7

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 288.7

FF:10182-103D2	60 years, female	313.7
FF:10165-103B3	76 years, female	263.7

Pons
Scaled Tags Per Million: 289.7

FF:10033-101E6

18-54 years, mixed

289.7

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	95.5

Pig sample

Sample description

nTPM

Pons
nTPM: 95.5

Samples: 3

Max nTPM: 109.9
Min nTPM: 87.0

Sample A	Female	109.9
Sample B	Female	89.5
Sample C	Male	87.0

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	154.6

Rat sample

Sample description

nTPM

Pons
nTPM: 154.6

Samples: 4

Max nTPM: 167.1
Min nTPM: 140.6

Sample A		159.4
Sample A		167.1
Sample A		151.3
Sample A		140.6