Brain tissue expression of TF in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	1086.6	nTPM
FANTOM5:	1673.6	Scaled Tags Per Million

Macaque:	527.8	nTPM
Mouse:	692.9	nTPM
Pig:	524.8	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1086.6

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 1004.7

2188	Female, age 91, both hemispheres	1251.3
2090	Male, age 80, both hemispheres	1181.8
2301	Female, age 85, both hemispheres	1024.9
1984	Male, age 76, both hemispheres	560.9

Dorsal cochlear nucleus
nTPM: 797.0

2187	Female, age 91, both hemispheres	1107.6
2378	Male, age 80, both hemispheres	896.2
2802	Male, age 74, right hemisphere	701.7
2058	Male, age 76, both hemispheres	662.5
2370	Male, age 61, both hemispheres	617.3

Dorsal tegmental nucleus
nTPM: 697.9

2083	Male, age 80, both hemispheres	1081.0
2326	Male, age 74, both hemispheres	848.9
1936	Male, age 76, left hemisphere	558.3
2358	Male, age 61, both hemispheres	303.5

Dorsolateral tegmental area
nTPM: 834.6

2751	Female, age 85, both hemispheres	1388.5
2654	Male, age 80, both hemispheres	995.9
2337	Male, age 61, both hemispheres	882.4
2360	Male, age 74, both hemispheres	577.7
2141	Male, age 76, both hemispheres	328.3

Kolliker-Fuse nucleus
nTPM: 751.9

2793	Female, age 91, left hemisphere	999.3
2163	Male, age 80, both hemispheres	742.2
2315	Male, age 76, right hemisphere	514.2

Lateral lemniscal nuclei
nTPM: 772.4

2320	Female, age 91, left hemisphere	1015.9
2036	Male, age 80, both hemispheres	845.2
2453	Male, age 74, right hemisphere	767.2
2169	Male, age 76, both hemispheres	625.3
2746	Female, age 85, left hemisphere	608.3

Lateral parabrachial nucleus
nTPM: 879.5

2792	Male, age 76, both hemispheres	1131.4
2790	Male, age 61, both hemispheres	931.9
2013	Male, age 80, both hemispheres	880.9
2139	Female, age 85, right hemisphere	573.9

Lateral vestibular nucleus
nTPM: 835.1

2311	Male, age 80, both hemispheres	1033.0
2184	Male, age 76, both hemispheres	637.3

Locus coeruleus
nTPM: 373.5

2162	Male, age 80, both hemispheres	496.5
2317	Female, age 72, unknown	473.3
2123	Female, age 91, both hemispheres	412.8
2014	Male, age 55, unknown	355.0
2720	Male, age 74, both hemispheres	338.9
2788	Male, age 74, unknown	308.1
1980	Male, age 76, both hemispheres	230.1

Medial parabrachial nucleus
nTPM: 905.9

2463	Female, age 85, right hemisphere	1226.4
2170	Female, age 91, both hemispheres	1201.3
2854	Male, age 80, both hemispheres	760.8
2156	Male, age 61, both hemispheres	687.0
2786	Male, age 76, both hemispheres	653.8

Medial periolivary nuclei
nTPM: 818.5

2791	Male, age 74, right hemisphere	1048.7
2081	Male, age 80, both hemispheres	947.0
2458	Female, age 91, both hemispheres	924.8
2063	Male, age 76, both hemispheres	699.5
2171	Female, age 85, both hemispheres	472.3

Motor facial nucleus
nTPM: 858.0

2126	Male, age 61, both hemispheres	1404.0
2365	Male, age 74, right hemisphere	1088.7
2795	Female, age 91, both hemispheres	751.3
2327	Male, age 80, both hemispheres	656.8
2697	Female, age 85, both hemispheres	655.5
2062	Male, age 76, both hemispheres	591.7

Motor trigeminal nucleus
nTPM: 761.3

2321	Female, age 91, both hemispheres	948.4
2560	Male, age 74, both hemispheres	943.1
2079	Male, age 80, both hemispheres	693.5
2309	Male, age 76, both hemispheres	659.1
2335	Male, age 61, both hemispheres	562.1

Nuclei of the trapezoid body
nTPM: 799.6

2368	Female, age 91, both hemispheres	1045.5
2159	Male, age 61, both hemispheres	895.6
2166	Male, age 80, both hemispheres	893.2
1983	Male, age 76, both hemispheres	673.6
2735	Female, age 85, both hemispheres	490.4

Nucleus raphe magnus
nTPM: 670.4

2459	Female, age 91, both hemispheres	976.8
2328	Male, age 80, both hemispheres	788.2
2455	Male, age 74, both hemispheres	761.2
2051	Male, age 76, both hemispheres	633.2
2160	Male, age 61, both hemispheres	494.0
2172	Female, age 85, both hemispheres	369.1

Paramedian reticular nucleus
nTPM: 919.3

2057	Male, age 80, both hemispheres	1191.7
2052	Male, age 76, both hemispheres	919.9
2050	Female, age 85, both hemispheres	872.5
2313	Male, age 61, both hemispheres	693.2

Pedunculopontine tegmental nucleus
nTPM: 728.8

2338	Male, age 61, both hemispheres	797.4
2334	Male, age 80, both hemispheres	758.5
1921	Female, age 85, both hemispheres	630.5

Pontine nuclei
nTPM: 911.1

2454	Male, age 74, left hemisphere	1395.4
2109	Female, age 72, unknown	1181.6
2319	Female, age 91, both hemispheres	970.1
2727	Male, age 61, right hemisphere	899.2
1863	Male, age 55, unknown	837.5
2115	Male, age 80, left hemisphere	729.3
1968	Male, age 76, left hemisphere	709.7
2787	Female, age 85, both hemispheres	566.4

Pontine raphe nucleus
nTPM: 568.3

2122	Female, age 85, midline	618.0
2853	Male, age 76, midline	518.6

Posteroventral cochlear nucleus
nTPM: 1034.5

2341	Male, age 80, both hemispheres	1534.9
2135	Female, age 91, both hemispheres	1287.6
2070	Male, age 76, both hemispheres	899.0
2371	Male, age 61, both hemispheres	763.6
2752	Female, age 85, both hemispheres	687.1

Principal sensory trigeminal nucleus
nTPM: 731.9

2367	Female, age 91, left hemisphere	1004.9
2008	Male, age 80, left hemisphere	782.2
2158	Male, age 61, both hemispheres	581.6
2324	Male, age 76, both hemispheres	558.9

Reticular pontine nucleus, caudal
nTPM: 999.3

2457	Female, age 91, both hemispheres	1313.4
2559	Male, age 74, both hemispheres	1107.0
2092	Male, age 76, both hemispheres	915.9
2332	Male, age 80, right hemisphere	661.0

Reticular pontine nucleus, oral
nTPM: 1086.6

2361	Male, age 74, both hemispheres	1660.0
2366	Female, age 91, both hemispheres	1076.5
1939	Male, age 80, both hemispheres	1037.3
2012	Female, age 85, both hemispheres	942.4
2167	Male, age 76, both hemispheres	716.9

Reticulotegmental nucleus
nTPM: 691.9

2322	Female, age 91, both hemispheres	896.6
2333	Male, age 80, both hemispheres	814.0
2452	Male, age 74, both hemispheres	684.3
2325	Male, age 76, both hemispheres	372.8

Spinal trigeminal nucleus, oral
nTPM: 693.7

2164	Male, age 80, both hemispheres	844.2
1978	Male, age 76, both hemispheres	624.7
2737	Female, age 85, both hemispheres	612.2

Subcoeruleus area
nTPM: 784.6

2369	Female, age 85, left hemisphere	1543.8
1958	Male, age 80, both hemispheres	769.9
2089	Male, age 76, left hemisphere	665.6
2451	Male, age 74, both hemispheres	474.2
2323	Female, age 91, left hemisphere	469.3

Superior olive
nTPM: 920.7

2364	Male, age 74, right hemisphere	1216.1
2020	Male, age 76, both hemispheres	1028.7
2329	Male, age 80, right hemisphere	844.7
1875	Female, age 85, both hemispheres	782.6
2561	Female, age 91, both hemispheres	731.3

Ventral periolivary nuclei
nTPM: 746.5

2023	Male, age 76, both hemispheres	1147.3
2165	Male, age 80, both hemispheres	783.5
2794	Female, age 91, left hemisphere	611.1
2130	Female, age 85, both hemispheres	444.0

Ventrolateral tegmental area, A5 NE cell group
nTPM: 826.3

2456	Female, age 91, both hemispheres	1160.2
2449	Male, age 74, both hemispheres	821.0
1959	Male, age 76, both hemispheres	801.3
2359	Male, age 61, both hemispheres	754.4
2161	Male, age 80, both hemispheres	713.5
2840	Female, age 85, both hemispheres	707.7

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1673.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1673.6

FF:10182-103D2	60 years, female	1703.0
FF:10165-103B3	76 years, female	1644.2

Pons
Scaled Tags Per Million: 1448.1

FF:10033-101E6

18-54 years, mixed

1448.1

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	527.8

Macaque sample

Sample description

nTPM

Pons
nTPM: 527.9

Samples: 2

Max nTPM: 548.1
Min nTPM: 507.6

Sample A		507.6
Sample B		548.1

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	524.8

Pig sample

Sample description

nTPM

Pons
nTPM: 524.8

Samples: 3

Max nTPM: 615.3
Min nTPM: 463.6

Sample A	Female	463.6
Sample B	Female	495.6
Sample C	Male	615.3

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	692.9

Mouse sample

Sample description

nTPM

Pons
nTPM: 692.9

Samples: 4

Max nTPM: 778.7
Min nTPM: 626.1

Sample A		778.7
Sample B		626.1
Sample C		724.3
Sample D		642.4