Brain tissue expression of RPL18A in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	458.2	nTPM
FANTOM5:	6.6	Scaled Tags Per Million

Mouse:	96.1	nTPM
Rat:	1.1	nTPM
Pig:	100.6	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	458.2

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 447.5

2188	Female, age 91, both hemispheres	470.0
2090	Male, age 80, both hemispheres	469.7
2301	Female, age 85, both hemispheres	450.2
1984	Male, age 76, both hemispheres	400.0

Dorsal cochlear nucleus
nTPM: 436.6

2187	Female, age 91, both hemispheres	479.4
2378	Male, age 80, both hemispheres	472.2
2802	Male, age 74, right hemisphere	441.5
2370	Male, age 61, both hemispheres	436.9
2058	Male, age 76, both hemispheres	353.2

Dorsal tegmental nucleus
nTPM: 447.2

2358	Male, age 61, both hemispheres	486.4
2326	Male, age 74, both hemispheres	481.0
2083	Male, age 80, both hemispheres	453.8
1936	Male, age 76, left hemisphere	367.5

Dorsolateral tegmental area
nTPM: 428.6

2337	Male, age 61, both hemispheres	545.1
2654	Male, age 80, both hemispheres	486.4
2360	Male, age 74, both hemispheres	407.8
2751	Female, age 85, both hemispheres	371.7
2141	Male, age 76, both hemispheres	331.9

Kolliker-Fuse nucleus
nTPM: 455.7

2315	Male, age 76, right hemisphere	525.2
2793	Female, age 91, left hemisphere	428.1
2163	Male, age 80, both hemispheres	413.7

Lateral lemniscal nuclei
nTPM: 384.9

2169	Male, age 76, both hemispheres	411.7
2746	Female, age 85, left hemisphere	409.7
2320	Female, age 91, left hemisphere	406.2
2036	Male, age 80, both hemispheres	352.3
2453	Male, age 74, right hemisphere	344.8

Lateral parabrachial nucleus
nTPM: 452.2

2013	Male, age 80, both hemispheres	507.9
2792	Male, age 76, both hemispheres	482.5
2139	Female, age 85, right hemisphere	448.1
2790	Male, age 61, both hemispheres	370.1

Lateral vestibular nucleus
nTPM: 458.2

2311	Male, age 80, both hemispheres	538.2
2184	Male, age 76, both hemispheres	378.3

Locus coeruleus
nTPM: 364.7

2123	Female, age 91, both hemispheres	426.6
2162	Male, age 80, both hemispheres	409.3
2720	Male, age 74, both hemispheres	405.4
2317	Female, age 72, unknown	392.8
1980	Male, age 76, both hemispheres	355.9
2014	Male, age 55, unknown	332.6
2788	Male, age 74, unknown	229.9

Medial parabrachial nucleus
nTPM: 418.3

2170	Female, age 91, both hemispheres	525.1
2156	Male, age 61, both hemispheres	410.1
2854	Male, age 80, both hemispheres	406.2
2463	Female, age 85, right hemisphere	391.5
2786	Male, age 76, both hemispheres	358.6

Medial periolivary nuclei
nTPM: 381.5

2063	Male, age 76, both hemispheres	436.1
2458	Female, age 91, both hemispheres	393.1
2081	Male, age 80, both hemispheres	389.6
2171	Female, age 85, both hemispheres	372.5
2791	Male, age 74, right hemisphere	316.4

Motor facial nucleus
nTPM: 372.0

2795	Female, age 91, both hemispheres	431.9
2062	Male, age 76, both hemispheres	413.4
2365	Male, age 74, right hemisphere	370.6
2697	Female, age 85, both hemispheres	364.2
2126	Male, age 61, both hemispheres	346.3
2327	Male, age 80, both hemispheres	305.9

Motor trigeminal nucleus
nTPM: 395.0

2335	Male, age 61, both hemispheres	449.1
2321	Female, age 91, both hemispheres	417.7
2560	Male, age 74, both hemispheres	409.0
2309	Male, age 76, both hemispheres	373.3
2079	Male, age 80, both hemispheres	326.0

Nuclei of the trapezoid body
nTPM: 390.4

1983	Male, age 76, both hemispheres	489.6
2735	Female, age 85, both hemispheres	376.3
2368	Female, age 91, both hemispheres	370.4
2166	Male, age 80, both hemispheres	366.1
2159	Male, age 61, both hemispheres	349.4

Nucleus raphe magnus
nTPM: 377.1

2051	Male, age 76, both hemispheres	400.9
2459	Female, age 91, both hemispheres	388.8
2172	Female, age 85, both hemispheres	388.7
2328	Male, age 80, both hemispheres	370.0
2160	Male, age 61, both hemispheres	358.2
2455	Male, age 74, both hemispheres	355.9

Paramedian reticular nucleus
nTPM: 362.1

2057	Male, age 80, both hemispheres	392.1
2313	Male, age 61, both hemispheres	386.9
2050	Female, age 85, both hemispheres	341.4
2052	Male, age 76, both hemispheres	327.9

Pedunculopontine tegmental nucleus
nTPM: 388.5

2334	Male, age 80, both hemispheres	454.0
2338	Male, age 61, both hemispheres	410.1
1921	Female, age 85, both hemispheres	301.4

Pontine nuclei
nTPM: 414.3

2787	Female, age 85, both hemispheres	513.1
2319	Female, age 91, both hemispheres	461.2
1968	Male, age 76, left hemisphere	434.2
1863	Male, age 55, unknown	420.2
2109	Female, age 72, unknown	393.0
2115	Male, age 80, left hemisphere	388.4
2454	Male, age 74, left hemisphere	367.3
2727	Male, age 61, right hemisphere	336.6

Pontine raphe nucleus
nTPM: 365.6

2122	Female, age 85, midline	383.4
2853	Male, age 76, midline	347.8

Posteroventral cochlear nucleus
nTPM: 432.0

2371	Male, age 61, both hemispheres	475.8
2135	Female, age 91, both hemispheres	455.0
2341	Male, age 80, both hemispheres	442.8
2070	Male, age 76, both hemispheres	420.2
2752	Female, age 85, both hemispheres	366.4

Principal sensory trigeminal nucleus
nTPM: 371.6

2324	Male, age 76, both hemispheres	405.1
2158	Male, age 61, both hemispheres	399.2
2367	Female, age 91, left hemisphere	391.2
2008	Male, age 80, left hemisphere	290.6

Reticular pontine nucleus, caudal
nTPM: 395.6

2092	Male, age 76, both hemispheres	438.7
2559	Male, age 74, both hemispheres	420.5
2457	Female, age 91, both hemispheres	384.1
2332	Male, age 80, right hemisphere	339.0

Reticular pontine nucleus, oral
nTPM: 381.4

2366	Female, age 91, both hemispheres	444.3
2167	Male, age 76, both hemispheres	407.6
1939	Male, age 80, both hemispheres	379.7
2361	Male, age 74, both hemispheres	338.4
2012	Female, age 85, both hemispheres	337.0

Reticulotegmental nucleus
nTPM: 399.7

2452	Male, age 74, both hemispheres	467.0
2322	Female, age 91, both hemispheres	398.1
2333	Male, age 80, both hemispheres	378.8
2325	Male, age 76, both hemispheres	354.9

Spinal trigeminal nucleus, oral
nTPM: 390.2

2164	Male, age 80, both hemispheres	429.7
1978	Male, age 76, both hemispheres	392.0
2737	Female, age 85, both hemispheres	348.8

Subcoeruleus area
nTPM: 396.2

2451	Male, age 74, both hemispheres	522.3
2323	Female, age 91, left hemisphere	393.8
2369	Female, age 85, left hemisphere	365.2
1958	Male, age 80, both hemispheres	355.7
2089	Male, age 76, left hemisphere	344.1

Superior olive
nTPM: 374.3

2020	Male, age 76, both hemispheres	407.2
2561	Female, age 91, both hemispheres	401.4
2364	Male, age 74, right hemisphere	362.9
2329	Male, age 80, right hemisphere	361.0
1875	Female, age 85, both hemispheres	338.9

Ventral periolivary nuclei
nTPM: 373.8

2023	Male, age 76, both hemispheres	414.1
2165	Male, age 80, both hemispheres	375.6
2794	Female, age 91, left hemisphere	367.4
2130	Female, age 85, both hemispheres	338.0

Ventrolateral tegmental area, A5 NE cell group
nTPM: 389.3

2161	Male, age 80, both hemispheres	448.0
2456	Female, age 91, both hemispheres	402.5
1959	Male, age 76, both hemispheres	389.3
2359	Male, age 61, both hemispheres	387.5
2840	Female, age 85, both hemispheres	368.1
2449	Male, age 74, both hemispheres	340.7

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	6.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 4.8

FF:10182-103D2	60 years, female	5.6
FF:10165-103B3	76 years, female	4.1

Pons
Scaled Tags Per Million: 6.6

FF:10033-101E6

18-54 years, mixed

6.6

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	100.6

Pig sample

Sample description

nTPM

Pons
nTPM: 100.6

Samples: 3

Max nTPM: 120.2
Min nTPM: 77.7

Sample A	Female	104.0
Sample B	Female	77.7
Sample C	Male	120.2

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	96.1

Mouse sample

Sample description

nTPM

Pons
nTPM: 96.1

Samples: 4

Max nTPM: 107.1
Min nTPM: 84.0

Sample A		107.1
Sample B		96.7
Sample C		84.0
Sample D		96.5

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1.1

Rat sample

Sample description

nTPM

Pons
nTPM: 1.1

Samples: 4

Max nTPM: 2.3
Min nTPM: 0.2

Sample A		1.5
Sample A		0.4
Sample A		0.2
Sample A		2.3