Brain tissue expression of RPS15 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	586.1	nTPM
FANTOM5:	76.2	Scaled Tags Per Million

Mouse:	539.7	nTPM
Rat:	388.9	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	586.1

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 546.3

2090	Male, age 80, both hemispheres	594.3
2188	Female, age 91, both hemispheres	578.6
2301	Female, age 85, both hemispheres	530.7
1984	Male, age 76, both hemispheres	481.6

Dorsal cochlear nucleus
nTPM: 511.4

2802	Male, age 74, right hemisphere	584.8
2187	Female, age 91, both hemispheres	560.0
2370	Male, age 61, both hemispheres	500.8
2058	Male, age 76, both hemispheres	467.9
2378	Male, age 80, both hemispheres	443.8

Dorsal tegmental nucleus
nTPM: 586.1

2358	Male, age 61, both hemispheres	663.2
2083	Male, age 80, both hemispheres	608.5
2326	Male, age 74, both hemispheres	584.4
1936	Male, age 76, left hemisphere	488.2

Dorsolateral tegmental area
nTPM: 558.5

2337	Male, age 61, both hemispheres	719.6
2654	Male, age 80, both hemispheres	654.8
2751	Female, age 85, both hemispheres	513.0
2141	Male, age 76, both hemispheres	454.2
2360	Male, age 74, both hemispheres	450.9

Kolliker-Fuse nucleus
nTPM: 569.6

2315	Male, age 76, right hemisphere	592.7
2793	Female, age 91, left hemisphere	559.1
2163	Male, age 80, both hemispheres	557.2

Lateral lemniscal nuclei
nTPM: 468.4

2746	Female, age 85, left hemisphere	529.5
2169	Male, age 76, both hemispheres	521.4
2320	Female, age 91, left hemisphere	507.1
2453	Male, age 74, right hemisphere	418.4
2036	Male, age 80, both hemispheres	365.9

Lateral parabrachial nucleus
nTPM: 573.5

2013	Male, age 80, both hemispheres	603.4
2792	Male, age 76, both hemispheres	597.0
2139	Female, age 85, right hemisphere	578.9
2790	Male, age 61, both hemispheres	514.6

Lateral vestibular nucleus
nTPM: 564.5

2311	Male, age 80, both hemispheres	640.1
2184	Male, age 76, both hemispheres	488.9

Locus coeruleus
nTPM: 459.2

2720	Male, age 74, both hemispheres	535.5
2123	Female, age 91, both hemispheres	526.7
2162	Male, age 80, both hemispheres	492.1
2014	Male, age 55, unknown	470.9
1980	Male, age 76, both hemispheres	448.0
2317	Female, age 72, unknown	420.2
2788	Male, age 74, unknown	321.2

Medial parabrachial nucleus
nTPM: 553.9

2170	Female, age 91, both hemispheres	634.7
2854	Male, age 80, both hemispheres	558.7
2156	Male, age 61, both hemispheres	544.8
2463	Female, age 85, right hemisphere	519.7
2786	Male, age 76, both hemispheres	511.4

Medial periolivary nuclei
nTPM: 477.0

2063	Male, age 76, both hemispheres	566.0
2081	Male, age 80, both hemispheres	507.7
2171	Female, age 85, both hemispheres	464.1
2458	Female, age 91, both hemispheres	449.9
2791	Male, age 74, right hemisphere	397.1

Motor facial nucleus
nTPM: 484.2

2062	Male, age 76, both hemispheres	562.0
2126	Male, age 61, both hemispheres	517.3
2697	Female, age 85, both hemispheres	503.8
2795	Female, age 91, both hemispheres	463.9
2365	Male, age 74, right hemisphere	449.9
2327	Male, age 80, both hemispheres	408.3

Motor trigeminal nucleus
nTPM: 511.9

2335	Male, age 61, both hemispheres	582.0
2560	Male, age 74, both hemispheres	528.3
2309	Male, age 76, both hemispheres	489.7
2321	Female, age 91, both hemispheres	489.0
2079	Male, age 80, both hemispheres	470.5

Nuclei of the trapezoid body
nTPM: 501.7

1983	Male, age 76, both hemispheres	680.8
2166	Male, age 80, both hemispheres	484.3
2735	Female, age 85, both hemispheres	481.4
2159	Male, age 61, both hemispheres	455.6
2368	Female, age 91, both hemispheres	406.5

Nucleus raphe magnus
nTPM: 468.9

2051	Male, age 76, both hemispheres	536.5
2455	Male, age 74, both hemispheres	468.2
2172	Female, age 85, both hemispheres	460.9
2328	Male, age 80, both hemispheres	456.9
2160	Male, age 61, both hemispheres	453.0
2459	Female, age 91, both hemispheres	437.7

Paramedian reticular nucleus
nTPM: 480.4

2057	Male, age 80, both hemispheres	519.9
2052	Male, age 76, both hemispheres	473.3
2313	Male, age 61, both hemispheres	472.8
2050	Female, age 85, both hemispheres	455.8

Pedunculopontine tegmental nucleus
nTPM: 519.9

2338	Male, age 61, both hemispheres	578.9
2334	Male, age 80, both hemispheres	554.1
1921	Female, age 85, both hemispheres	426.6

Pontine nuclei
nTPM: 539.5

2787	Female, age 85, both hemispheres	670.5
1968	Male, age 76, left hemisphere	591.0
1863	Male, age 55, unknown	569.1
2319	Female, age 91, both hemispheres	550.2
2109	Female, age 72, unknown	522.0
2115	Male, age 80, left hemisphere	520.0
2454	Male, age 74, left hemisphere	473.7
2727	Male, age 61, right hemisphere	419.7

Pontine raphe nucleus
nTPM: 483.7

2122	Female, age 85, midline	526.4
2853	Male, age 76, midline	441.0

Posteroventral cochlear nucleus
nTPM: 556.0

2135	Female, age 91, both hemispheres	610.3
2341	Male, age 80, both hemispheres	580.9
2070	Male, age 76, both hemispheres	552.3
2371	Male, age 61, both hemispheres	540.9
2752	Female, age 85, both hemispheres	495.5

Principal sensory trigeminal nucleus
nTPM: 466.1

2324	Male, age 76, both hemispheres	486.1
2367	Female, age 91, left hemisphere	475.4
2158	Male, age 61, both hemispheres	473.4
2008	Male, age 80, left hemisphere	429.7

Reticular pontine nucleus, caudal
nTPM: 510.9

2092	Male, age 76, both hemispheres	586.2
2559	Male, age 74, both hemispheres	561.4
2457	Female, age 91, both hemispheres	472.3
2332	Male, age 80, right hemisphere	423.9

Reticular pontine nucleus, oral
nTPM: 510.7

2366	Female, age 91, both hemispheres	573.4
2167	Male, age 76, both hemispheres	535.1
1939	Male, age 80, both hemispheres	497.7
2361	Male, age 74, both hemispheres	481.1
2012	Female, age 85, both hemispheres	466.4

Reticulotegmental nucleus
nTPM: 495.3

2452	Male, age 74, both hemispheres	587.5
2322	Female, age 91, both hemispheres	492.5
2333	Male, age 80, both hemispheres	470.3
2325	Male, age 76, both hemispheres	431.1

Spinal trigeminal nucleus, oral
nTPM: 490.1

2164	Male, age 80, both hemispheres	515.7
1978	Male, age 76, both hemispheres	494.8
2737	Female, age 85, both hemispheres	459.7

Subcoeruleus area
nTPM: 510.9

2451	Male, age 74, both hemispheres	595.5
2369	Female, age 85, left hemisphere	493.6
2089	Male, age 76, left hemisphere	490.2
1958	Male, age 80, both hemispheres	487.9
2323	Female, age 91, left hemisphere	487.1

Superior olive
nTPM: 480.6

2020	Male, age 76, both hemispheres	624.8
2561	Female, age 91, both hemispheres	497.1
1875	Female, age 85, both hemispheres	451.6
2329	Male, age 80, right hemisphere	430.9
2364	Male, age 74, right hemisphere	398.3

Ventral periolivary nuclei
nTPM: 486.2

2023	Male, age 76, both hemispheres	569.4
2165	Male, age 80, both hemispheres	482.4
2130	Female, age 85, both hemispheres	467.7
2794	Female, age 91, left hemisphere	425.1

Ventrolateral tegmental area, A5 NE cell group
nTPM: 474.1

2161	Male, age 80, both hemispheres	514.8
1959	Male, age 76, both hemispheres	506.8
2840	Female, age 85, both hemispheres	491.6
2359	Male, age 61, both hemispheres	472.1
2449	Male, age 74, both hemispheres	432.8
2456	Female, age 91, both hemispheres	426.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	76.2

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 55.0

FF:10182-103D2	60 years, female	58.9
FF:10165-103B3	76 years, female	51.2

Pons
Scaled Tags Per Million: 76.2

FF:10033-101E6

18-54 years, mixed

76.2

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	539.7

Mouse sample

Sample description

nTPM

Pons
nTPM: 539.7

Samples: 4

Max nTPM: 587.2
Min nTPM: 475.2

Sample A		475.2
Sample B		587.2
Sample C		547.6
Sample D		548.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	388.9

Rat sample

Sample description

nTPM

Pons
nTPM: 388.9

Samples: 4

Max nTPM: 407.8
Min nTPM: 374.8

Sample A		378.9
Sample A		407.8
Sample A		394.2
Sample A		374.8