Brain tissue expression of RPS25 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	265.7	nTPM
FANTOM5:	734.2	Scaled Tags Per Million

Macaque:	311.5	nTPM
Mouse:	197.5	nTPM
Pig:	306.7	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	265.7

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 235.0

2090	Male, age 80, both hemispheres	291.2
2188	Female, age 91, both hemispheres	264.5
1984	Male, age 76, both hemispheres	196.6
2301	Female, age 85, both hemispheres	187.6

Dorsal cochlear nucleus
nTPM: 233.8

2802	Male, age 74, right hemisphere	273.7
2187	Female, age 91, both hemispheres	248.8
2370	Male, age 61, both hemispheres	243.3
2378	Male, age 80, both hemispheres	224.6
2058	Male, age 76, both hemispheres	178.7

Dorsal tegmental nucleus
nTPM: 245.0

2083	Male, age 80, both hemispheres	276.5
2326	Male, age 74, both hemispheres	260.8
2358	Male, age 61, both hemispheres	231.0
1936	Male, age 76, left hemisphere	211.7

Dorsolateral tegmental area
nTPM: 229.7

2654	Male, age 80, both hemispheres	297.2
2751	Female, age 85, both hemispheres	231.0
2337	Male, age 61, both hemispheres	230.3
2360	Male, age 74, both hemispheres	210.6
2141	Male, age 76, both hemispheres	179.4

Kolliker-Fuse nucleus
nTPM: 228.5

2315	Male, age 76, right hemisphere	270.7
2793	Female, age 91, left hemisphere	216.5
2163	Male, age 80, both hemispheres	198.3

Lateral lemniscal nuclei
nTPM: 173.1

2169	Male, age 76, both hemispheres	183.2
2453	Male, age 74, right hemisphere	176.0
2746	Female, age 85, left hemisphere	174.7
2036	Male, age 80, both hemispheres	166.5
2320	Female, age 91, left hemisphere	165.1

Lateral parabrachial nucleus
nTPM: 230.8

2792	Male, age 76, both hemispheres	271.3
2013	Male, age 80, both hemispheres	236.7
2139	Female, age 85, right hemisphere	212.7
2790	Male, age 61, both hemispheres	202.6

Lateral vestibular nucleus
nTPM: 202.5

2311	Male, age 80, both hemispheres	239.9
2184	Male, age 76, both hemispheres	165.2

Locus coeruleus
nTPM: 194.1

2720	Male, age 74, both hemispheres	231.0
2123	Female, age 91, both hemispheres	210.5
2162	Male, age 80, both hemispheres	199.3
2317	Female, age 72, unknown	190.1
2014	Male, age 55, unknown	187.0
2788	Male, age 74, unknown	181.6
1980	Male, age 76, both hemispheres	159.0

Medial parabrachial nucleus
nTPM: 219.2

2170	Female, age 91, both hemispheres	283.8
2854	Male, age 80, both hemispheres	227.5
2463	Female, age 85, right hemisphere	205.8
2786	Male, age 76, both hemispheres	196.2
2156	Male, age 61, both hemispheres	182.6

Medial periolivary nuclei
nTPM: 201.5

2063	Male, age 76, both hemispheres	238.7
2081	Male, age 80, both hemispheres	211.7
2458	Female, age 91, both hemispheres	203.9
2791	Male, age 74, right hemisphere	193.2
2171	Female, age 85, both hemispheres	160.2

Motor facial nucleus
nTPM: 197.6

2126	Male, age 61, both hemispheres	249.8
2365	Male, age 74, right hemisphere	202.4
2062	Male, age 76, both hemispheres	202.3
2795	Female, age 91, both hemispheres	200.4
2697	Female, age 85, both hemispheres	195.4
2327	Male, age 80, both hemispheres	135.3

Motor trigeminal nucleus
nTPM: 195.5

2335	Male, age 61, both hemispheres	222.6
2309	Male, age 76, both hemispheres	205.0
2560	Male, age 74, both hemispheres	196.5
2321	Female, age 91, both hemispheres	191.2
2079	Male, age 80, both hemispheres	162.2

Nuclei of the trapezoid body
nTPM: 189.1

1983	Male, age 76, both hemispheres	235.2
2166	Male, age 80, both hemispheres	200.8
2159	Male, age 61, both hemispheres	180.9
2368	Female, age 91, both hemispheres	173.8
2735	Female, age 85, both hemispheres	154.7

Nucleus raphe magnus
nTPM: 173.0

2051	Male, age 76, both hemispheres	202.6
2459	Female, age 91, both hemispheres	182.6
2455	Male, age 74, both hemispheres	176.3
2328	Male, age 80, both hemispheres	168.2
2160	Male, age 61, both hemispheres	163.0
2172	Female, age 85, both hemispheres	145.2

Paramedian reticular nucleus
nTPM: 220.7

2052	Male, age 76, both hemispheres	249.5
2057	Male, age 80, both hemispheres	216.9
2313	Male, age 61, both hemispheres	210.7
2050	Female, age 85, both hemispheres	205.8

Pedunculopontine tegmental nucleus
nTPM: 215.8

2338	Male, age 61, both hemispheres	247.6
2334	Male, age 80, both hemispheres	222.9
1921	Female, age 85, both hemispheres	177.0

Pontine nuclei
nTPM: 200.9

2319	Female, age 91, both hemispheres	216.3
2115	Male, age 80, left hemisphere	214.9
1863	Male, age 55, unknown	213.2
2454	Male, age 74, left hemisphere	212.5
1968	Male, age 76, left hemisphere	211.4
2109	Female, age 72, unknown	208.3
2787	Female, age 85, both hemispheres	169.5
2727	Male, age 61, right hemisphere	161.3

Pontine raphe nucleus
nTPM: 186.7

2122	Female, age 85, midline	192.4
2853	Male, age 76, midline	181.1

Posteroventral cochlear nucleus
nTPM: 265.7

2341	Male, age 80, both hemispheres	342.2
2135	Female, age 91, both hemispheres	300.3
2371	Male, age 61, both hemispheres	251.9
2070	Male, age 76, both hemispheres	229.9
2752	Female, age 85, both hemispheres	204.4

Principal sensory trigeminal nucleus
nTPM: 180.9

2158	Male, age 61, both hemispheres	188.5
2324	Male, age 76, both hemispheres	183.4
2367	Female, age 91, left hemisphere	181.3
2008	Male, age 80, left hemisphere	170.5

Reticular pontine nucleus, caudal
nTPM: 213.1

2457	Female, age 91, both hemispheres	246.5
2559	Male, age 74, both hemispheres	232.8
2092	Male, age 76, both hemispheres	229.0
2332	Male, age 80, right hemisphere	144.0

Reticular pontine nucleus, oral
nTPM: 214.8

2366	Female, age 91, both hemispheres	232.1
1939	Male, age 80, both hemispheres	222.6
2167	Male, age 76, both hemispheres	217.5
2361	Male, age 74, both hemispheres	215.7
2012	Female, age 85, both hemispheres	185.9

Reticulotegmental nucleus
nTPM: 193.4

2452	Male, age 74, both hemispheres	227.4
2322	Female, age 91, both hemispheres	205.1
2333	Male, age 80, both hemispheres	175.3
2325	Male, age 76, both hemispheres	165.9

Spinal trigeminal nucleus, oral
nTPM: 191.4

1978	Male, age 76, both hemispheres	201.5
2164	Male, age 80, both hemispheres	197.3
2737	Female, age 85, both hemispheres	175.4

Subcoeruleus area
nTPM: 215.2

2451	Male, age 74, both hemispheres	268.6
2369	Female, age 85, left hemisphere	242.0
1958	Male, age 80, both hemispheres	207.8
2089	Male, age 76, left hemisphere	180.8
2323	Female, age 91, left hemisphere	176.6

Superior olive
nTPM: 193.9

2020	Male, age 76, both hemispheres	243.3
2364	Male, age 74, right hemisphere	209.9
1875	Female, age 85, both hemispheres	182.4
2561	Female, age 91, both hemispheres	171.9
2329	Male, age 80, right hemisphere	161.7

Ventral periolivary nuclei
nTPM: 188.4

2023	Male, age 76, both hemispheres	242.2
2165	Male, age 80, both hemispheres	182.3
2794	Female, age 91, left hemisphere	174.3
2130	Female, age 85, both hemispheres	155.0

Ventrolateral tegmental area, A5 NE cell group
nTPM: 193.9

2359	Male, age 61, both hemispheres	207.6
2161	Male, age 80, both hemispheres	204.4
2840	Female, age 85, both hemispheres	192.1
2456	Female, age 91, both hemispheres	190.0
1959	Male, age 76, both hemispheres	189.9
2449	Male, age 74, both hemispheres	179.4

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	734.2

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 734.2

FF:10182-103D2	60 years, female	803.1
FF:10165-103B3	76 years, female	665.3

Pons
Scaled Tags Per Million: 324.9

FF:10033-101E6

18-54 years, mixed

324.9

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	311.5

Macaque sample

Sample description

nTPM

Pons
nTPM: 311.5

Samples: 2

Max nTPM: 332.5
Min nTPM: 290.5

Sample A		290.5
Sample B		332.5

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	306.7

Pig sample

Sample description

nTPM

Pons
nTPM: 306.7

Samples: 3

Max nTPM: 375.6
Min nTPM: 217.6

Sample A	Female	327.0
Sample B	Female	217.6
Sample C	Male	375.6

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	197.5

Mouse sample

Sample description

nTPM

Pons
nTPM: 197.5

Samples: 4

Max nTPM: 201.4
Min nTPM: 187.6

Sample A		187.6
Sample B		199.5
Sample C		201.3
Sample D		201.4