Brain tissue expression of WBP2 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	477.0	nTPM
FANTOM5:	1218.5	Scaled Tags Per Million

Macaque:	246.2	nTPM
Mouse:	219.0	nTPM
Rat:	199.7	nTPM
Pig:	276.4	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	477.0

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 322.9

2301	Female, age 85, both hemispheres	394.0
2188	Female, age 91, both hemispheres	331.2
1984	Male, age 76, both hemispheres	283.3
2090	Male, age 80, both hemispheres	283.1

Dorsal cochlear nucleus
nTPM: 326.5

2187	Female, age 91, both hemispheres	348.2
2370	Male, age 61, both hemispheres	335.8
2802	Male, age 74, right hemisphere	334.1
2058	Male, age 76, both hemispheres	330.4
2378	Male, age 80, both hemispheres	284.1

Dorsal tegmental nucleus
nTPM: 338.8

2358	Male, age 61, both hemispheres	397.8
2083	Male, age 80, both hemispheres	373.9
1936	Male, age 76, left hemisphere	303.6
2326	Male, age 74, both hemispheres	280.0

Dorsolateral tegmental area
nTPM: 309.0

2654	Male, age 80, both hemispheres	365.7
2751	Female, age 85, both hemispheres	323.6
2141	Male, age 76, both hemispheres	308.4
2337	Male, age 61, both hemispheres	295.7
2360	Male, age 74, both hemispheres	251.7

Kolliker-Fuse nucleus
nTPM: 421.8

2793	Female, age 91, left hemisphere	458.7
2163	Male, age 80, both hemispheres	428.1
2315	Male, age 76, right hemisphere	378.6

Lateral lemniscal nuclei
nTPM: 434.0

2169	Male, age 76, both hemispheres	494.3
2036	Male, age 80, both hemispheres	467.8
2453	Male, age 74, right hemisphere	427.3
2746	Female, age 85, left hemisphere	426.9
2320	Female, age 91, left hemisphere	353.7

Lateral parabrachial nucleus
nTPM: 401.0

2139	Female, age 85, right hemisphere	467.0
2790	Male, age 61, both hemispheres	414.9
2792	Male, age 76, both hemispheres	376.7
2013	Male, age 80, both hemispheres	345.4

Lateral vestibular nucleus
nTPM: 387.5

2184	Male, age 76, both hemispheres	414.3
2311	Male, age 80, both hemispheres	360.7

Locus coeruleus
nTPM: 453.5

2720	Male, age 74, both hemispheres	538.4
2123	Female, age 91, both hemispheres	500.9
2014	Male, age 55, unknown	472.3
2317	Female, age 72, unknown	447.8
1980	Male, age 76, both hemispheres	442.1
2162	Male, age 80, both hemispheres	403.4
2788	Male, age 74, unknown	369.9

Medial parabrachial nucleus
nTPM: 374.2

2854	Male, age 80, both hemispheres	444.8
2156	Male, age 61, both hemispheres	406.9
2170	Female, age 91, both hemispheres	387.6
2786	Male, age 76, both hemispheres	349.3
2463	Female, age 85, right hemisphere	282.3

Medial periolivary nuclei
nTPM: 407.9

2171	Female, age 85, both hemispheres	530.4
2063	Male, age 76, both hemispheres	470.3
2791	Male, age 74, right hemisphere	392.3
2458	Female, age 91, both hemispheres	332.2
2081	Male, age 80, both hemispheres	314.4

Motor facial nucleus
nTPM: 436.2

2697	Female, age 85, both hemispheres	495.1
2062	Male, age 76, both hemispheres	487.2
2795	Female, age 91, both hemispheres	452.8
2327	Male, age 80, both hemispheres	441.6
2365	Male, age 74, right hemisphere	426.4
2126	Male, age 61, both hemispheres	314.1

Motor trigeminal nucleus
nTPM: 368.6

2560	Male, age 74, both hemispheres	421.7
2079	Male, age 80, both hemispheres	405.2
2335	Male, age 61, both hemispheres	357.1
2309	Male, age 76, both hemispheres	341.6
2321	Female, age 91, both hemispheres	317.4

Nuclei of the trapezoid body
nTPM: 445.1

2159	Male, age 61, both hemispheres	500.6
1983	Male, age 76, both hemispheres	479.6
2735	Female, age 85, both hemispheres	477.6
2368	Female, age 91, both hemispheres	386.4
2166	Male, age 80, both hemispheres	381.3

Nucleus raphe magnus
nTPM: 477.0

2160	Male, age 61, both hemispheres	647.4
2172	Female, age 85, both hemispheres	561.8
2455	Male, age 74, both hemispheres	448.2
2051	Male, age 76, both hemispheres	426.2
2328	Male, age 80, both hemispheres	422.8
2459	Female, age 91, both hemispheres	355.5

Paramedian reticular nucleus
nTPM: 377.6

2050	Female, age 85, both hemispheres	451.2
2313	Male, age 61, both hemispheres	400.1
2057	Male, age 80, both hemispheres	379.1
2052	Male, age 76, both hemispheres	280.0

Pedunculopontine tegmental nucleus
nTPM: 356.9

2334	Male, age 80, both hemispheres	409.2
1921	Female, age 85, both hemispheres	332.1
2338	Male, age 61, both hemispheres	329.3

Pontine nuclei
nTPM: 463.5

2787	Female, age 85, both hemispheres	662.4
1863	Male, age 55, unknown	597.3
2727	Male, age 61, right hemisphere	532.1
1968	Male, age 76, left hemisphere	469.3
2109	Female, age 72, unknown	433.5
2454	Male, age 74, left hemisphere	359.4
2115	Male, age 80, left hemisphere	337.4
2319	Female, age 91, both hemispheres	316.7

Pontine raphe nucleus
nTPM: 403.1

2122	Female, age 85, midline	433.2
2853	Male, age 76, midline	373.0

Posteroventral cochlear nucleus
nTPM: 304.2

2752	Female, age 85, both hemispheres	350.9
2070	Male, age 76, both hemispheres	338.5
2371	Male, age 61, both hemispheres	336.8
2135	Female, age 91, both hemispheres	248.7
2341	Male, age 80, both hemispheres	246.0

Principal sensory trigeminal nucleus
nTPM: 428.0

2158	Male, age 61, both hemispheres	539.3
2324	Male, age 76, both hemispheres	407.1
2008	Male, age 80, left hemisphere	407.0
2367	Female, age 91, left hemisphere	358.4

Reticular pontine nucleus, caudal
nTPM: 387.2

2332	Male, age 80, right hemisphere	462.5
2092	Male, age 76, both hemispheres	429.3
2457	Female, age 91, both hemispheres	352.8
2559	Male, age 74, both hemispheres	304.1

Reticular pontine nucleus, oral
nTPM: 363.3

2012	Female, age 85, both hemispheres	387.4
2366	Female, age 91, both hemispheres	366.9
1939	Male, age 80, both hemispheres	359.0
2361	Male, age 74, both hemispheres	353.8
2167	Male, age 76, both hemispheres	349.2

Reticulotegmental nucleus
nTPM: 371.1

2325	Male, age 76, both hemispheres	400.6
2322	Female, age 91, both hemispheres	364.7
2333	Male, age 80, both hemispheres	360.4
2452	Male, age 74, both hemispheres	358.7

Spinal trigeminal nucleus, oral
nTPM: 354.0

2164	Male, age 80, both hemispheres	395.9
2737	Female, age 85, both hemispheres	346.5
1978	Male, age 76, both hemispheres	319.7

Subcoeruleus area
nTPM: 374.6

1958	Male, age 80, both hemispheres	425.9
2323	Female, age 91, left hemisphere	421.0
2089	Male, age 76, left hemisphere	380.1
2451	Male, age 74, both hemispheres	329.6
2369	Female, age 85, left hemisphere	316.4

Superior olive
nTPM: 408.7

1875	Female, age 85, both hemispheres	488.2
2329	Male, age 80, right hemisphere	415.7
2561	Female, age 91, both hemispheres	387.3
2364	Male, age 74, right hemisphere	381.4
2020	Male, age 76, both hemispheres	370.9

Ventral periolivary nuclei
nTPM: 431.1

2130	Female, age 85, both hemispheres	493.3
2165	Male, age 80, both hemispheres	485.9
2023	Male, age 76, both hemispheres	377.3
2794	Female, age 91, left hemisphere	367.8

Ventrolateral tegmental area, A5 NE cell group
nTPM: 419.8

2840	Female, age 85, both hemispheres	467.9
2359	Male, age 61, both hemispheres	438.9
1959	Male, age 76, both hemispheres	428.8
2449	Male, age 74, both hemispheres	425.2
2161	Male, age 80, both hemispheres	405.3
2456	Female, age 91, both hemispheres	352.6

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1218.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 499.1

FF:10165-103B3	76 years, female	535.6
FF:10182-103D2	60 years, female	462.6

Pons
Scaled Tags Per Million: 1218.5

FF:10033-101E6

18-54 years, mixed

1218.5

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	246.2

Macaque sample

Sample description

nTPM

Pons
nTPM: 246.2

Samples: 2

Max nTPM: 273.8
Min nTPM: 218.5

Sample A		273.8
Sample B		218.5

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	276.4

Pig sample

Sample description

nTPM

Pons
nTPM: 276.4

Samples: 3

Max nTPM: 315.7
Min nTPM: 230.2

Sample A	Female	315.7
Sample B	Female	230.2
Sample C	Male	283.4

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	219.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 219.0

Samples: 4

Max nTPM: 222.7
Min nTPM: 214.4

Sample A		218.0
Sample B		221.1
Sample C		222.7
Sample D		214.4

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	199.7

Rat sample

Sample description

nTPM

Pons
nTPM: 199.7

Samples: 4

Max nTPM: 230.8
Min nTPM: 171.7

Sample A		230.8
Sample A		201.6
Sample A		171.7
Sample A		194.8