Brain tissue expression of RPL35 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	563.5	nTPM
FANTOM5:	374.7	Scaled Tags Per Million

Macaque:	162.0	nTPM
Mouse:	58.8	nTPM
Rat:	2.0	nTPM
Pig:	369.7	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	563.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 497.2

2090	Male, age 80, both hemispheres	568.8
2188	Female, age 91, both hemispheres	548.2
2301	Female, age 85, both hemispheres	499.8
1984	Male, age 76, both hemispheres	372.0

Dorsal cochlear nucleus
nTPM: 476.2

2187	Female, age 91, both hemispheres	546.4
2802	Male, age 74, right hemisphere	533.4
2370	Male, age 61, both hemispheres	452.8
2378	Male, age 80, both hemispheres	437.6
2058	Male, age 76, both hemispheres	410.9

Dorsal tegmental nucleus
nTPM: 563.5

2358	Male, age 61, both hemispheres	690.0
2083	Male, age 80, both hemispheres	569.6
2326	Male, age 74, both hemispheres	535.1
1936	Male, age 76, left hemisphere	459.1

Dorsolateral tegmental area
nTPM: 512.5

2337	Male, age 61, both hemispheres	688.9
2654	Male, age 80, both hemispheres	565.0
2141	Male, age 76, both hemispheres	462.9
2751	Female, age 85, both hemispheres	444.2
2360	Male, age 74, both hemispheres	401.5

Kolliker-Fuse nucleus
nTPM: 491.6

2793	Female, age 91, left hemisphere	501.7
2163	Male, age 80, both hemispheres	493.4
2315	Male, age 76, right hemisphere	479.6

Lateral lemniscal nuclei
nTPM: 371.6

2169	Male, age 76, both hemispheres	430.3
2320	Female, age 91, left hemisphere	390.2
2453	Male, age 74, right hemisphere	382.6
2746	Female, age 85, left hemisphere	370.7
2036	Male, age 80, both hemispheres	284.0

Lateral parabrachial nucleus
nTPM: 496.2

2792	Male, age 76, both hemispheres	579.9
2013	Male, age 80, both hemispheres	526.2
2790	Male, age 61, both hemispheres	444.4
2139	Female, age 85, right hemisphere	434.1

Lateral vestibular nucleus
nTPM: 499.1

2311	Male, age 80, both hemispheres	603.4
2184	Male, age 76, both hemispheres	394.9

Locus coeruleus
nTPM: 474.3

2720	Male, age 74, both hemispheres	566.7
2162	Male, age 80, both hemispheres	516.3
2123	Female, age 91, both hemispheres	503.5
2014	Male, age 55, unknown	480.1
2317	Female, age 72, unknown	429.6
1980	Male, age 76, both hemispheres	427.0
2788	Male, age 74, unknown	396.9

Medial parabrachial nucleus
nTPM: 500.2

2170	Female, age 91, both hemispheres	601.6
2854	Male, age 80, both hemispheres	529.0
2156	Male, age 61, both hemispheres	501.8
2786	Male, age 76, both hemispheres	455.7
2463	Female, age 85, right hemisphere	412.8

Medial periolivary nuclei
nTPM: 388.8

2081	Male, age 80, both hemispheres	445.4
2063	Male, age 76, both hemispheres	414.2
2458	Female, age 91, both hemispheres	402.2
2171	Female, age 85, both hemispheres	349.8
2791	Male, age 74, right hemisphere	332.5

Motor facial nucleus
nTPM: 401.5

2697	Female, age 85, both hemispheres	460.2
2126	Male, age 61, both hemispheres	429.6
2365	Male, age 74, right hemisphere	404.1
2795	Female, age 91, both hemispheres	391.9
2062	Male, age 76, both hemispheres	388.2
2327	Male, age 80, both hemispheres	334.8

Motor trigeminal nucleus
nTPM: 440.7

2335	Male, age 61, both hemispheres	534.0
2321	Female, age 91, both hemispheres	440.9
2309	Male, age 76, both hemispheres	440.3
2560	Male, age 74, both hemispheres	399.7
2079	Male, age 80, both hemispheres	388.7

Nuclei of the trapezoid body
nTPM: 382.0

1983	Male, age 76, both hemispheres	519.4
2166	Male, age 80, both hemispheres	413.5
2159	Male, age 61, both hemispheres	344.1
2368	Female, age 91, both hemispheres	328.4
2735	Female, age 85, both hemispheres	304.7

Nucleus raphe magnus
nTPM: 385.5

2051	Male, age 76, both hemispheres	439.4
2455	Male, age 74, both hemispheres	396.6
2328	Male, age 80, both hemispheres	394.2
2459	Female, age 91, both hemispheres	376.4
2172	Female, age 85, both hemispheres	360.2
2160	Male, age 61, both hemispheres	346.1

Paramedian reticular nucleus
nTPM: 453.3

2052	Male, age 76, both hemispheres	523.1
2050	Female, age 85, both hemispheres	444.8
2313	Male, age 61, both hemispheres	434.0
2057	Male, age 80, both hemispheres	411.4

Pedunculopontine tegmental nucleus
nTPM: 516.8

2338	Male, age 61, both hemispheres	582.7
2334	Male, age 80, both hemispheres	542.6
1921	Female, age 85, both hemispheres	425.1

Pontine nuclei
nTPM: 414.1

2319	Female, age 91, both hemispheres	493.9
1863	Male, age 55, unknown	458.6
1968	Male, age 76, left hemisphere	435.2
2115	Male, age 80, left hemisphere	430.7
2454	Male, age 74, left hemisphere	428.2
2787	Female, age 85, both hemispheres	392.2
2109	Female, age 72, unknown	371.1
2727	Male, age 61, right hemisphere	302.5

Pontine raphe nucleus
nTPM: 425.8

2853	Male, age 76, midline	436.2
2122	Female, age 85, midline	415.3

Posteroventral cochlear nucleus
nTPM: 494.0

2341	Male, age 80, both hemispheres	560.4
2135	Female, age 91, both hemispheres	536.8
2371	Male, age 61, both hemispheres	490.7
2070	Male, age 76, both hemispheres	452.4
2752	Female, age 85, both hemispheres	429.6

Principal sensory trigeminal nucleus
nTPM: 390.9

2367	Female, age 91, left hemisphere	428.4
2324	Male, age 76, both hemispheres	425.5
2158	Male, age 61, both hemispheres	379.5
2008	Male, age 80, left hemisphere	330.3

Reticular pontine nucleus, caudal
nTPM: 435.7

2457	Female, age 91, both hemispheres	487.1
2559	Male, age 74, both hemispheres	482.6
2092	Male, age 76, both hemispheres	467.4
2332	Male, age 80, right hemisphere	305.8

Reticular pontine nucleus, oral
nTPM: 464.9

2366	Female, age 91, both hemispheres	526.8
2167	Male, age 76, both hemispheres	522.6
1939	Male, age 80, both hemispheres	501.6
2012	Female, age 85, both hemispheres	404.4
2361	Male, age 74, both hemispheres	369.2

Reticulotegmental nucleus
nTPM: 452.2

2452	Male, age 74, both hemispheres	516.0
2322	Female, age 91, both hemispheres	453.3
2333	Male, age 80, both hemispheres	431.5
2325	Male, age 76, both hemispheres	408.1

Spinal trigeminal nucleus, oral
nTPM: 433.6

2164	Male, age 80, both hemispheres	466.5
1978	Male, age 76, both hemispheres	438.2
2737	Female, age 85, both hemispheres	396.0

Subcoeruleus area
nTPM: 468.5

2451	Male, age 74, both hemispheres	547.7
2369	Female, age 85, left hemisphere	474.4
1958	Male, age 80, both hemispheres	472.7
2323	Female, age 91, left hemisphere	472.0
2089	Male, age 76, left hemisphere	375.8

Superior olive
nTPM: 387.4

2020	Male, age 76, both hemispheres	490.0
2561	Female, age 91, both hemispheres	406.2
2364	Male, age 74, right hemisphere	369.7
2329	Male, age 80, right hemisphere	348.8
1875	Female, age 85, both hemispheres	322.1

Ventral periolivary nuclei
nTPM: 414.2

2023	Male, age 76, both hemispheres	441.2
2165	Male, age 80, both hemispheres	437.7
2794	Female, age 91, left hemisphere	395.2
2130	Female, age 85, both hemispheres	382.8

Ventrolateral tegmental area, A5 NE cell group
nTPM: 421.7

2840	Female, age 85, both hemispheres	466.4
2359	Male, age 61, both hemispheres	465.1
1959	Male, age 76, both hemispheres	428.9
2161	Male, age 80, both hemispheres	426.2
2449	Male, age 74, both hemispheres	382.7
2456	Female, age 91, both hemispheres	360.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	374.7

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 374.7

FF:10182-103D2	60 years, female	404.2
FF:10165-103B3	76 years, female	345.2

Pons
Scaled Tags Per Million: 213.3

FF:10033-101E6

18-54 years, mixed

213.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	162.0

Macaque sample

Sample description

nTPM

Pons
nTPM: 162.1

Samples: 2

Max nTPM: 180.3
Min nTPM: 143.8

Sample A		143.8
Sample B		180.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	369.7

Pig sample

Sample description

nTPM

Pons
nTPM: 369.7

Samples: 3

Max nTPM: 443.2
Min nTPM: 279.0

Sample A	Female	387.0
Sample B	Female	279.0
Sample C	Male	443.2

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	58.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 58.8

Samples: 4

Max nTPM: 61.6
Min nTPM: 57.2

Sample A		57.7
Sample B		61.6
Sample C		58.7
Sample D		57.2

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2.0

Rat sample

Sample description

nTPM

Pons
nTPM: 2.0

Samples: 4

Max nTPM: 2.8
Min nTPM: 1.4

Sample A		2.8
Sample A		1.4
Sample A		1.6
Sample A		2.2