Brain tissue expression of RPS6 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	678.8	nTPM
FANTOM5:	232.1	Scaled Tags Per Million

Macaque:	497.2	nTPM
Mouse:	329.0	nTPM
Rat:	0.0	nTPM
Pig:	72.7	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	678.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 656.1

2301	Female, age 85, both hemispheres	725.0
2188	Female, age 91, both hemispheres	722.0
2090	Male, age 80, both hemispheres	702.4
1984	Male, age 76, both hemispheres	474.9

Dorsal cochlear nucleus
nTPM: 649.7

2378	Male, age 80, both hemispheres	704.8
2802	Male, age 74, right hemisphere	702.8
2187	Female, age 91, both hemispheres	700.5
2370	Male, age 61, both hemispheres	602.7
2058	Male, age 76, both hemispheres	537.6

Dorsal tegmental nucleus
nTPM: 623.0

2358	Male, age 61, both hemispheres	664.5
2326	Male, age 74, both hemispheres	654.4
2083	Male, age 80, both hemispheres	615.8
1936	Male, age 76, left hemisphere	557.3

Dorsolateral tegmental area
nTPM: 596.5

2337	Male, age 61, both hemispheres	720.6
2654	Male, age 80, both hemispheres	713.0
2751	Female, age 85, both hemispheres	555.2
2360	Male, age 74, both hemispheres	526.9
2141	Male, age 76, both hemispheres	467.1

Kolliker-Fuse nucleus
nTPM: 640.3

2793	Female, age 91, left hemisphere	726.2
2315	Male, age 76, right hemisphere	643.5
2163	Male, age 80, both hemispheres	551.0

Lateral lemniscal nuclei
nTPM: 506.8

2169	Male, age 76, both hemispheres	550.2
2320	Female, age 91, left hemisphere	548.0
2746	Female, age 85, left hemisphere	530.6
2453	Male, age 74, right hemisphere	462.1
2036	Male, age 80, both hemispheres	443.3

Lateral parabrachial nucleus
nTPM: 671.8

2792	Male, age 76, both hemispheres	902.5
2013	Male, age 80, both hemispheres	710.7
2139	Female, age 85, right hemisphere	539.8
2790	Male, age 61, both hemispheres	534.2

Lateral vestibular nucleus
nTPM: 588.2

2311	Male, age 80, both hemispheres	704.5
2184	Male, age 76, both hemispheres	471.8

Locus coeruleus
nTPM: 469.7

2720	Male, age 74, both hemispheres	623.9
2162	Male, age 80, both hemispheres	518.3
2123	Female, age 91, both hemispheres	483.9
2317	Female, age 72, unknown	429.4
2788	Male, age 74, unknown	424.7
2014	Male, age 55, unknown	424.3
1980	Male, age 76, both hemispheres	383.0

Medial parabrachial nucleus
nTPM: 606.0

2170	Female, age 91, both hemispheres	750.3
2854	Male, age 80, both hemispheres	673.5
2463	Female, age 85, right hemisphere	542.4
2156	Male, age 61, both hemispheres	532.4
2786	Male, age 76, both hemispheres	531.3

Medial periolivary nuclei
nTPM: 543.7

2081	Male, age 80, both hemispheres	616.6
2458	Female, age 91, both hemispheres	594.8
2063	Male, age 76, both hemispheres	580.0
2791	Male, age 74, right hemisphere	468.0
2171	Female, age 85, both hemispheres	458.9

Motor facial nucleus
nTPM: 560.7

2697	Female, age 85, both hemispheres	644.5
2795	Female, age 91, both hemispheres	611.0
2126	Male, age 61, both hemispheres	577.2
2062	Male, age 76, both hemispheres	546.0
2365	Male, age 74, right hemisphere	516.3
2327	Male, age 80, both hemispheres	469.4

Motor trigeminal nucleus
nTPM: 552.3

2321	Female, age 91, both hemispheres	629.6
2335	Male, age 61, both hemispheres	557.2
2560	Male, age 74, both hemispheres	548.9
2309	Male, age 76, both hemispheres	530.2
2079	Male, age 80, both hemispheres	495.8

Nuclei of the trapezoid body
nTPM: 541.7

1983	Male, age 76, both hemispheres	653.6
2166	Male, age 80, both hemispheres	580.3
2159	Male, age 61, both hemispheres	519.8
2368	Female, age 91, both hemispheres	508.2
2735	Female, age 85, both hemispheres	446.3

Nucleus raphe magnus
nTPM: 512.9

2051	Male, age 76, both hemispheres	623.6
2459	Female, age 91, both hemispheres	586.3
2328	Male, age 80, both hemispheres	510.9
2172	Female, age 85, both hemispheres	471.7
2455	Male, age 74, both hemispheres	447.5
2160	Male, age 61, both hemispheres	437.2

Paramedian reticular nucleus
nTPM: 588.5

2052	Male, age 76, both hemispheres	694.9
2050	Female, age 85, both hemispheres	571.4
2057	Male, age 80, both hemispheres	547.9
2313	Male, age 61, both hemispheres	539.6

Pedunculopontine tegmental nucleus
nTPM: 574.3

2338	Male, age 61, both hemispheres	665.8
2334	Male, age 80, both hemispheres	623.6
1921	Female, age 85, both hemispheres	433.6

Pontine nuclei
nTPM: 546.6

2319	Female, age 91, both hemispheres	672.1
1968	Male, age 76, left hemisphere	599.3
2115	Male, age 80, left hemisphere	588.8
2454	Male, age 74, left hemisphere	548.0
1863	Male, age 55, unknown	547.5
2109	Female, age 72, unknown	510.8
2787	Female, age 85, both hemispheres	454.9
2727	Male, age 61, right hemisphere	451.3

Pontine raphe nucleus
nTPM: 497.8

2853	Male, age 76, midline	498.9
2122	Female, age 85, midline	496.7

Posteroventral cochlear nucleus
nTPM: 678.8

2341	Male, age 80, both hemispheres	823.6
2135	Female, age 91, both hemispheres	784.1
2371	Male, age 61, both hemispheres	723.5
2752	Female, age 85, both hemispheres	542.9
2070	Male, age 76, both hemispheres	520.1

Principal sensory trigeminal nucleus
nTPM: 518.9

2367	Female, age 91, left hemisphere	607.3
2324	Male, age 76, both hemispheres	520.0
2158	Male, age 61, both hemispheres	479.9
2008	Male, age 80, left hemisphere	468.4

Reticular pontine nucleus, caudal
nTPM: 559.2

2457	Female, age 91, both hemispheres	604.9
2559	Male, age 74, both hemispheres	604.5
2092	Male, age 76, both hemispheres	590.2
2332	Male, age 80, right hemisphere	437.0

Reticular pontine nucleus, oral
nTPM: 559.2

2366	Female, age 91, both hemispheres	668.8
1939	Male, age 80, both hemispheres	587.1
2167	Male, age 76, both hemispheres	561.8
2012	Female, age 85, both hemispheres	506.5
2361	Male, age 74, both hemispheres	471.6

Reticulotegmental nucleus
nTPM: 581.7

2452	Male, age 74, both hemispheres	635.8
2322	Female, age 91, both hemispheres	622.3
2333	Male, age 80, both hemispheres	563.5
2325	Male, age 76, both hemispheres	505.2

Spinal trigeminal nucleus, oral
nTPM: 488.6

2164	Male, age 80, both hemispheres	560.0
1978	Male, age 76, both hemispheres	490.2
2737	Female, age 85, both hemispheres	415.6

Subcoeruleus area
nTPM: 552.2

2369	Female, age 85, left hemisphere	629.1
2451	Male, age 74, both hemispheres	617.9
1958	Male, age 80, both hemispheres	545.3
2089	Male, age 76, left hemisphere	491.2
2323	Female, age 91, left hemisphere	477.5

Superior olive
nTPM: 569.8

2020	Male, age 76, both hemispheres	690.3
2561	Female, age 91, both hemispheres	650.7
2329	Male, age 80, right hemisphere	524.3
2364	Male, age 74, right hemisphere	492.2
1875	Female, age 85, both hemispheres	491.5

Ventral periolivary nuclei
nTPM: 565.1

2023	Male, age 76, both hemispheres	680.8
2794	Female, age 91, left hemisphere	601.3
2165	Male, age 80, both hemispheres	512.3
2130	Female, age 85, both hemispheres	466.0

Ventrolateral tegmental area, A5 NE cell group
nTPM: 548.9

2840	Female, age 85, both hemispheres	601.1
2161	Male, age 80, both hemispheres	587.1
1959	Male, age 76, both hemispheres	582.7
2456	Female, age 91, both hemispheres	545.6
2359	Male, age 61, both hemispheres	543.4
2449	Male, age 74, both hemispheres	433.7

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	232.1

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 232.1

FF:10182-103D2	60 years, female	289.0
FF:10165-103B3	76 years, female	175.2

Pons
Scaled Tags Per Million: 111.3

FF:10033-101E6

18-54 years, mixed

111.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	497.2

Macaque sample

Sample description

nTPM

Pons
nTPM: 497.2

Samples: 2

Max nTPM: 551.9
Min nTPM: 442.5

Sample A		442.5
Sample B		551.9

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	72.7

Pig sample

Sample description

nTPM

Pons
nTPM: 72.7

Samples: 3

Max nTPM: 84.7
Min nTPM: 60.4

Sample A	Female	72.9
Sample B	Female	60.4
Sample C	Male	84.7

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	329.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 329.1

Samples: 4

Max nTPM: 338.3
Min nTPM: 313.6

Sample A		338.3
Sample B		313.6
Sample C		336.6
Sample D		327.7

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	0.0

Rat sample

Sample description

nTPM

Pons
nTPM: 0.1

Samples: 4

Max nTPM: 0.2
Min nTPM: 0.0

Sample A		0.0
Sample A		0.0
Sample A		0.2
Sample A		0.0