Brain tissue expression of CADPS in pons

PONS - Expression summary

Mouse brain, Intensity
Ponsⁱ

95.282

RNA expressionⁱ

HPA Brain:	261.1	nTPM
FANTOM5:	255.1	Scaled Tags Per Million

Macaque:	147.8	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - Mouse brain profileⁱ Protein expression in mouse brain using immunofluorescence is reported as fluorescence intensity. , antibody HPA059328
Pons mean intensity	95.282
	intensityⁱ Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity.	FRONT BACK
Barrington's nucleus	-
Koelliker-fuse nucleus	-
Motor tregiminal nucleus	45.325
Parabrachial nucleus	17.757
Principle sensory trigeminal nucleus	44.395
Locus coeruleus	44.501
Pontine nucleus	8.149
Vestibular nucleus	30.296
Pontine reticular nucleus, oral	20.578
Lateral lemniscus	58.736
Superior paraolivary nucleus	30.014

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	261.1

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 110.2

1984	Male, age 76, both hemispheres	162.5
2301	Female, age 85, both hemispheres	100.2
2188	Female, age 91, both hemispheres	99.6
2090	Male, age 80, both hemispheres	78.4

Dorsal cochlear nucleus
nTPM: 86.8

2058	Male, age 76, both hemispheres	128.4
2370	Male, age 61, both hemispheres	89.9
2187	Female, age 91, both hemispheres	84.9
2378	Male, age 80, both hemispheres	77.4
2802	Male, age 74, right hemisphere	53.2

Dorsal tegmental nucleus
nTPM: 94.9

2358	Male, age 61, both hemispheres	113.2
2083	Male, age 80, both hemispheres	105.3
1936	Male, age 76, left hemisphere	101.4
2326	Male, age 74, both hemispheres	59.7

Dorsolateral tegmental area
nTPM: 89.5

2141	Male, age 76, both hemispheres	126.8
2654	Male, age 80, both hemispheres	101.5
2751	Female, age 85, both hemispheres	96.0
2360	Male, age 74, both hemispheres	72.5
2337	Male, age 61, both hemispheres	50.5

Kolliker-Fuse nucleus
nTPM: 120.4

2163	Male, age 80, both hemispheres	148.0
2793	Female, age 91, left hemisphere	115.9
2315	Male, age 76, right hemisphere	97.3

Lateral lemniscal nuclei
nTPM: 220.0

2169	Male, age 76, both hemispheres	294.7
2453	Male, age 74, right hemisphere	243.0
2036	Male, age 80, both hemispheres	238.0
2746	Female, age 85, left hemisphere	197.6
2320	Female, age 91, left hemisphere	126.7

Lateral parabrachial nucleus
nTPM: 137.1

2139	Female, age 85, right hemisphere	240.1
2013	Male, age 80, both hemispheres	136.3
2790	Male, age 61, both hemispheres	102.8
2792	Male, age 76, both hemispheres	69.2

Lateral vestibular nucleus
nTPM: 111.5

2184	Male, age 76, both hemispheres	139.4
2311	Male, age 80, both hemispheres	83.6

Locus coeruleus
nTPM: 170.6

2123	Female, age 91, both hemispheres	266.9
2720	Male, age 74, both hemispheres	213.7
2014	Male, age 55, unknown	158.8
1980	Male, age 76, both hemispheres	156.8
2788	Male, age 74, unknown	140.3
2162	Male, age 80, both hemispheres	131.7
2317	Female, age 72, unknown	125.7

Medial parabrachial nucleus
nTPM: 110.8

2854	Male, age 80, both hemispheres	159.9
2156	Male, age 61, both hemispheres	115.9
2463	Female, age 85, right hemisphere	97.5
2170	Female, age 91, both hemispheres	90.8
2786	Male, age 76, both hemispheres	90.0

Medial periolivary nuclei
nTPM: 202.8

2171	Female, age 85, both hemispheres	344.3
2063	Male, age 76, both hemispheres	290.4
2791	Male, age 74, right hemisphere	155.1
2458	Female, age 91, both hemispheres	117.9
2081	Male, age 80, both hemispheres	106.1

Motor facial nucleus
nTPM: 188.8

2062	Male, age 76, both hemispheres	310.0
2365	Male, age 74, right hemisphere	214.8
2327	Male, age 80, both hemispheres	192.1
2697	Female, age 85, both hemispheres	192.1
2795	Female, age 91, both hemispheres	129.2
2126	Male, age 61, both hemispheres	94.6

Motor trigeminal nucleus
nTPM: 124.5

2079	Male, age 80, both hemispheres	190.2
2560	Male, age 74, both hemispheres	142.1
2321	Female, age 91, both hemispheres	99.6
2335	Male, age 61, both hemispheres	96.1
2309	Male, age 76, both hemispheres	94.3

Nuclei of the trapezoid body
nTPM: 261.1

2159	Male, age 61, both hemispheres	440.4
2735	Female, age 85, both hemispheres	297.1
1983	Male, age 76, both hemispheres	260.1
2166	Male, age 80, both hemispheres	165.8
2368	Female, age 91, both hemispheres	142.2

Nucleus raphe magnus
nTPM: 259.2

2160	Male, age 61, both hemispheres	359.1
2172	Female, age 85, both hemispheres	338.1
2455	Male, age 74, both hemispheres	303.6
2051	Male, age 76, both hemispheres	207.7
2328	Male, age 80, both hemispheres	190.1
2459	Female, age 91, both hemispheres	156.8

Paramedian reticular nucleus
nTPM: 173.0

2050	Female, age 85, both hemispheres	309.8
2057	Male, age 80, both hemispheres	135.6
2313	Male, age 61, both hemispheres	126.3
2052	Male, age 76, both hemispheres	120.0

Pedunculopontine tegmental nucleus
nTPM: 111.1

1921	Female, age 85, both hemispheres	121.8
2338	Male, age 61, both hemispheres	111.7
2334	Male, age 80, both hemispheres	99.8

Pontine nuclei
nTPM: 253.5

1863	Male, age 55, unknown	391.0
2727	Male, age 61, right hemisphere	337.8
2787	Female, age 85, both hemispheres	334.6
2109	Female, age 72, unknown	296.9
1968	Male, age 76, left hemisphere	251.1
2454	Male, age 74, left hemisphere	190.8
2115	Male, age 80, left hemisphere	126.9
2319	Female, age 91, both hemispheres	99.0

Pontine raphe nucleus
nTPM: 166.3

2122	Female, age 85, midline	234.4
2853	Male, age 76, midline	98.1

Posteroventral cochlear nucleus
nTPM: 85.0

2752	Female, age 85, both hemispheres	147.7
2070	Male, age 76, both hemispheres	126.4
2371	Male, age 61, both hemispheres	72.7
2341	Male, age 80, both hemispheres	50.1
2135	Female, age 91, both hemispheres	28.0

Principal sensory trigeminal nucleus
nTPM: 199.9

2158	Male, age 61, both hemispheres	318.8
2008	Male, age 80, left hemisphere	239.8
2324	Male, age 76, both hemispheres	126.3
2367	Female, age 91, left hemisphere	114.5

Reticular pontine nucleus, caudal
nTPM: 147.7

2332	Male, age 80, right hemisphere	213.0
2092	Male, age 76, both hemispheres	193.4
2457	Female, age 91, both hemispheres	109.5
2559	Male, age 74, both hemispheres	74.9

Reticular pontine nucleus, oral
nTPM: 153.2

2012	Female, age 85, both hemispheres	217.6
2361	Male, age 74, both hemispheres	204.8
1939	Male, age 80, both hemispheres	131.3
2167	Male, age 76, both hemispheres	116.8
2366	Female, age 91, both hemispheres	95.5

Reticulotegmental nucleus
nTPM: 135.4

2325	Male, age 76, both hemispheres	194.2
2322	Female, age 91, both hemispheres	122.7
2333	Male, age 80, both hemispheres	120.1
2452	Male, age 74, both hemispheres	104.8

Spinal trigeminal nucleus, oral
nTPM: 116.9

2737	Female, age 85, both hemispheres	151.1
2164	Male, age 80, both hemispheres	114.8
1978	Male, age 76, both hemispheres	84.9

Subcoeruleus area
nTPM: 121.2

2089	Male, age 76, left hemisphere	172.9
1958	Male, age 80, both hemispheres	167.7
2323	Female, age 91, left hemisphere	122.6
2369	Female, age 85, left hemisphere	75.6
2451	Male, age 74, both hemispheres	67.2

Superior olive
nTPM: 191.8

1875	Female, age 85, both hemispheres	296.3
2364	Male, age 74, right hemisphere	177.3
2020	Male, age 76, both hemispheres	173.7
2329	Male, age 80, right hemisphere	168.6
2561	Female, age 91, both hemispheres	143.1

Ventral periolivary nuclei
nTPM: 213.5

2130	Female, age 85, both hemispheres	282.6
2165	Male, age 80, both hemispheres	228.1
2794	Female, age 91, left hemisphere	184.5
2023	Male, age 76, both hemispheres	158.6

Ventrolateral tegmental area, A5 NE cell group
nTPM: 163.8

2449	Male, age 74, both hemispheres	264.6
1959	Male, age 76, both hemispheres	199.1
2840	Female, age 85, both hemispheres	177.0
2161	Male, age 80, both hemispheres	153.4
2359	Male, age 61, both hemispheres	94.8
2456	Female, age 91, both hemispheres	94.0

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	255.1

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 91.8

FF:10182-103D2	60 years, female	114.6
FF:10165-103B3	76 years, female	69.0

Pons
Scaled Tags Per Million: 255.1

FF:10033-101E6

18-54 years, mixed

255.1

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	147.8

Macaque sample

Sample description

nTPM

Pons
nTPM: 147.8

Samples: 2

Max nTPM: 200.6
Min nTPM: 95.0

Sample A		200.6
Sample B		95.0