Brain tissue expression of RPL15 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	694.5	nTPM
FANTOM5:	129.5	Scaled Tags Per Million

Macaque:	199.5	nTPM
Mouse:	116.9	nTPM
Rat:	67.0	nTPM
Pig:	323.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - Annotated protein expression
Pending normal tissue analysis

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	694.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 624.8

2090	Male, age 80, both hemispheres	651.3
2188	Female, age 91, both hemispheres	640.4
2301	Female, age 85, both hemispheres	637.7
1984	Male, age 76, both hemispheres	570.1

Dorsal cochlear nucleus
nTPM: 694.5

2802	Male, age 74, right hemisphere	830.0
2378	Male, age 80, both hemispheres	715.9
2370	Male, age 61, both hemispheres	664.7
2187	Female, age 91, both hemispheres	659.7
2058	Male, age 76, both hemispheres	602.2

Dorsal tegmental nucleus
nTPM: 644.1

2326	Male, age 74, both hemispheres	735.2
2083	Male, age 80, both hemispheres	654.1
2358	Male, age 61, both hemispheres	613.8
1936	Male, age 76, left hemisphere	573.5

Dorsolateral tegmental area
nTPM: 642.7

2654	Male, age 80, both hemispheres	741.2
2337	Male, age 61, both hemispheres	656.4
2751	Female, age 85, both hemispheres	641.3
2360	Male, age 74, both hemispheres	626.0
2141	Male, age 76, both hemispheres	548.8

Kolliker-Fuse nucleus
nTPM: 628.8

2315	Male, age 76, right hemisphere	724.5
2163	Male, age 80, both hemispheres	581.8
2793	Female, age 91, left hemisphere	580.0

Lateral lemniscal nuclei
nTPM: 583.7

2169	Male, age 76, both hemispheres	652.3
2746	Female, age 85, left hemisphere	619.1
2036	Male, age 80, both hemispheres	560.0
2320	Female, age 91, left hemisphere	544.9
2453	Male, age 74, right hemisphere	542.4

Lateral parabrachial nucleus
nTPM: 654.1

2013	Male, age 80, both hemispheres	738.0
2792	Male, age 76, both hemispheres	665.2
2139	Female, age 85, right hemisphere	647.2
2790	Male, age 61, both hemispheres	566.1

Lateral vestibular nucleus
nTPM: 595.5

2311	Male, age 80, both hemispheres	685.4
2184	Male, age 76, both hemispheres	505.7

Locus coeruleus
nTPM: 622.6

2014	Male, age 55, unknown	701.0
2123	Female, age 91, both hemispheres	654.0
2317	Female, age 72, unknown	653.2
2162	Male, age 80, both hemispheres	639.6
2720	Male, age 74, both hemispheres	635.6
1980	Male, age 76, both hemispheres	555.2
2788	Male, age 74, unknown	519.8

Medial parabrachial nucleus
nTPM: 623.5

2170	Female, age 91, both hemispheres	763.1
2463	Female, age 85, right hemisphere	640.5
2854	Male, age 80, both hemispheres	603.5
2786	Male, age 76, both hemispheres	564.3
2156	Male, age 61, both hemispheres	545.9

Medial periolivary nuclei
nTPM: 603.0

2063	Male, age 76, both hemispheres	768.5
2171	Female, age 85, both hemispheres	581.5
2081	Male, age 80, both hemispheres	573.2
2791	Male, age 74, right hemisphere	554.2
2458	Female, age 91, both hemispheres	537.9

Motor facial nucleus
nTPM: 598.7

2062	Male, age 76, both hemispheres	733.6
2795	Female, age 91, both hemispheres	686.8
2365	Male, age 74, right hemisphere	621.9
2126	Male, age 61, both hemispheres	556.9
2697	Female, age 85, both hemispheres	505.3
2327	Male, age 80, both hemispheres	487.5

Motor trigeminal nucleus
nTPM: 562.7

2560	Male, age 74, both hemispheres	645.8
2321	Female, age 91, both hemispheres	585.0
2309	Male, age 76, both hemispheres	553.7
2335	Male, age 61, both hemispheres	538.4
2079	Male, age 80, both hemispheres	490.7

Nuclei of the trapezoid body
nTPM: 630.2

1983	Male, age 76, both hemispheres	763.2
2735	Female, age 85, both hemispheres	624.1
2368	Female, age 91, both hemispheres	618.4
2166	Male, age 80, both hemispheres	582.3
2159	Male, age 61, both hemispheres	562.9

Nucleus raphe magnus
nTPM: 597.9

2051	Male, age 76, both hemispheres	671.9
2172	Female, age 85, both hemispheres	603.0
2160	Male, age 61, both hemispheres	602.9
2455	Male, age 74, both hemispheres	589.5
2459	Female, age 91, both hemispheres	565.4
2328	Male, age 80, both hemispheres	554.9

Paramedian reticular nucleus
nTPM: 604.5

2050	Female, age 85, both hemispheres	629.8
2057	Male, age 80, both hemispheres	628.0
2313	Male, age 61, both hemispheres	583.2
2052	Male, age 76, both hemispheres	577.2

Pedunculopontine tegmental nucleus
nTPM: 595.8

2334	Male, age 80, both hemispheres	653.8
2338	Male, age 61, both hemispheres	571.0
1921	Female, age 85, both hemispheres	562.7

Pontine nuclei
nTPM: 652.4

1863	Male, age 55, unknown	761.3
2787	Female, age 85, both hemispheres	732.1
1968	Male, age 76, left hemisphere	713.0
2319	Female, age 91, both hemispheres	654.1
2109	Female, age 72, unknown	631.8
2727	Male, age 61, right hemisphere	590.2
2454	Male, age 74, left hemisphere	584.4
2115	Male, age 80, left hemisphere	551.9

Pontine raphe nucleus
nTPM: 585.6

2122	Female, age 85, midline	600.7
2853	Male, age 76, midline	570.4

Posteroventral cochlear nucleus
nTPM: 637.2

2371	Male, age 61, both hemispheres	718.9
2752	Female, age 85, both hemispheres	648.6
2341	Male, age 80, both hemispheres	634.7
2135	Female, age 91, both hemispheres	591.9
2070	Male, age 76, both hemispheres	591.7

Principal sensory trigeminal nucleus
nTPM: 548.6

2158	Male, age 61, both hemispheres	589.9
2367	Female, age 91, left hemisphere	554.6
2008	Male, age 80, left hemisphere	526.9
2324	Male, age 76, both hemispheres	523.0

Reticular pontine nucleus, caudal
nTPM: 589.1

2092	Male, age 76, both hemispheres	666.7
2559	Male, age 74, both hemispheres	629.1
2457	Female, age 91, both hemispheres	584.1
2332	Male, age 80, right hemisphere	476.4

Reticular pontine nucleus, oral
nTPM: 604.8

2366	Female, age 91, both hemispheres	623.5
2012	Female, age 85, both hemispheres	611.7
2167	Male, age 76, both hemispheres	606.2
1939	Male, age 80, both hemispheres	605.6
2361	Male, age 74, both hemispheres	576.8

Reticulotegmental nucleus
nTPM: 605.0

2452	Male, age 74, both hemispheres	700.7
2322	Female, age 91, both hemispheres	579.0
2333	Male, age 80, both hemispheres	575.8
2325	Male, age 76, both hemispheres	564.4

Spinal trigeminal nucleus, oral
nTPM: 567.6

1978	Male, age 76, both hemispheres	587.7
2164	Male, age 80, both hemispheres	584.0
2737	Female, age 85, both hemispheres	531.1

Subcoeruleus area
nTPM: 634.8

2451	Male, age 74, both hemispheres	784.7
2369	Female, age 85, left hemisphere	670.5
2323	Female, age 91, left hemisphere	603.2
1958	Male, age 80, both hemispheres	596.2
2089	Male, age 76, left hemisphere	519.2

Superior olive
nTPM: 606.1

2020	Male, age 76, both hemispheres	674.0
2364	Male, age 74, right hemisphere	640.8
2561	Female, age 91, both hemispheres	601.6
1875	Female, age 85, both hemispheres	601.3
2329	Male, age 80, right hemisphere	512.9

Ventral periolivary nuclei
nTPM: 616.0

2023	Male, age 76, both hemispheres	708.4
2130	Female, age 85, both hemispheres	606.3
2165	Male, age 80, both hemispheres	601.2
2794	Female, age 91, left hemisphere	548.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 587.5

2161	Male, age 80, both hemispheres	645.9
2456	Female, age 91, both hemispheres	606.4
2359	Male, age 61, both hemispheres	594.9
1959	Male, age 76, both hemispheres	586.0
2840	Female, age 85, both hemispheres	549.4
2449	Male, age 74, both hemispheres	542.4

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	129.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 72.1

FF:10165-103B3	76 years, female	73.5
FF:10182-103D2	60 years, female	70.7

Pons
Scaled Tags Per Million: 129.5

FF:10033-101E6

18-54 years, mixed

129.5

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	199.5

Macaque sample

Sample description

nTPM

Pons
nTPM: 199.5

Samples: 2

Max nTPM: 212.3
Min nTPM: 186.6

Sample A		186.6
Sample B		212.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	323.5

Pig sample

Sample description

nTPM

Pons
nTPM: 323.5

Samples: 3

Max nTPM: 393.7
Min nTPM: 245.2

Sample A	Female	393.7
Sample B	Female	245.2
Sample C	Male	331.5

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	116.9

Mouse sample

Sample description

nTPM

Pons
nTPM: 116.9

Samples: 4

Max nTPM: 129.8
Min nTPM: 95.4

Sample A		95.4
Sample B		129.8
Sample C		121.4
Sample D		120.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	67.0

Rat sample

Sample description

nTPM

Pons
nTPM: 67.0

Samples: 4

Max nTPM: 70.0
Min nTPM: 63.2

Sample A		63.2
Sample A		70.0
Sample A		66.8
Sample A		67.9