Brain tissue expression of RPL23A in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	337.3	nTPM
FANTOM5:	11.4	Scaled Tags Per Million

Macaque:	942.6	nTPM
Mouse:	572.5	nTPM
Pig:	2334.3	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	337.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 281.8

2090	Male, age 80, both hemispheres	342.0
2188	Female, age 91, both hemispheres	311.2
1984	Male, age 76, both hemispheres	250.4
2301	Female, age 85, both hemispheres	223.7

Dorsal cochlear nucleus
nTPM: 303.6

2802	Male, age 74, right hemisphere	355.1
2187	Female, age 91, both hemispheres	311.1
2378	Male, age 80, both hemispheres	295.3
2370	Male, age 61, both hemispheres	292.6
2058	Male, age 76, both hemispheres	264.1

Dorsal tegmental nucleus
nTPM: 273.8

2083	Male, age 80, both hemispheres	346.2
2326	Male, age 74, both hemispheres	339.5
1936	Male, age 76, left hemisphere	225.4
2358	Male, age 61, both hemispheres	184.3

Dorsolateral tegmental area
nTPM: 297.7

2654	Male, age 80, both hemispheres	391.2
2751	Female, age 85, both hemispheres	316.7
2337	Male, age 61, both hemispheres	293.0
2360	Male, age 74, both hemispheres	263.9
2141	Male, age 76, both hemispheres	223.6

Kolliker-Fuse nucleus
nTPM: 271.7

2315	Male, age 76, right hemisphere	351.3
2163	Male, age 80, both hemispheres	235.7
2793	Female, age 91, left hemisphere	228.1

Lateral lemniscal nuclei
nTPM: 224.9

2320	Female, age 91, left hemisphere	246.0
2036	Male, age 80, both hemispheres	231.3
2453	Male, age 74, right hemisphere	219.7
2169	Male, age 76, both hemispheres	216.2
2746	Female, age 85, left hemisphere	211.3

Lateral parabrachial nucleus
nTPM: 285.5

2792	Male, age 76, both hemispheres	337.6
2013	Male, age 80, both hemispheres	294.6
2139	Female, age 85, right hemisphere	269.5
2790	Male, age 61, both hemispheres	240.4

Lateral vestibular nucleus
nTPM: 262.0

2311	Male, age 80, both hemispheres	297.6
2184	Male, age 76, both hemispheres	226.5

Locus coeruleus
nTPM: 245.8

2123	Female, age 91, both hemispheres	278.1
2317	Female, age 72, unknown	272.3
2162	Male, age 80, both hemispheres	256.8
2014	Male, age 55, unknown	244.1
2720	Male, age 74, both hemispheres	230.8
2788	Male, age 74, unknown	229.8
1980	Male, age 76, both hemispheres	208.5

Medial parabrachial nucleus
nTPM: 272.1

2170	Female, age 91, both hemispheres	328.4
2463	Female, age 85, right hemisphere	298.5
2156	Male, age 61, both hemispheres	254.8
2786	Male, age 76, both hemispheres	253.3
2854	Male, age 80, both hemispheres	225.2

Medial periolivary nuclei
nTPM: 246.6

2063	Male, age 76, both hemispheres	312.7
2081	Male, age 80, both hemispheres	269.6
2791	Male, age 74, right hemisphere	239.2
2458	Female, age 91, both hemispheres	222.2
2171	Female, age 85, both hemispheres	189.5

Motor facial nucleus
nTPM: 238.7

2126	Male, age 61, both hemispheres	298.0
2062	Male, age 76, both hemispheres	274.0
2795	Female, age 91, both hemispheres	258.1
2365	Male, age 74, right hemisphere	224.9
2697	Female, age 85, both hemispheres	190.4
2327	Male, age 80, both hemispheres	186.4

Motor trigeminal nucleus
nTPM: 261.8

2309	Male, age 76, both hemispheres	278.6
2335	Male, age 61, both hemispheres	268.9
2321	Female, age 91, both hemispheres	262.3
2560	Male, age 74, both hemispheres	250.1
2079	Male, age 80, both hemispheres	249.2

Nuclei of the trapezoid body
nTPM: 248.2

1983	Male, age 76, both hemispheres	356.3
2166	Male, age 80, both hemispheres	234.0
2159	Male, age 61, both hemispheres	229.0
2368	Female, age 91, both hemispheres	228.8
2735	Female, age 85, both hemispheres	193.1

Nucleus raphe magnus
nTPM: 213.7

2455	Male, age 74, both hemispheres	255.9
2160	Male, age 61, both hemispheres	224.9
2459	Female, age 91, both hemispheres	222.9
2051	Male, age 76, both hemispheres	211.8
2328	Male, age 80, both hemispheres	209.2
2172	Female, age 85, both hemispheres	157.1

Paramedian reticular nucleus
nTPM: 280.5

2057	Male, age 80, both hemispheres	316.2
2313	Male, age 61, both hemispheres	297.2
2052	Male, age 76, both hemispheres	291.3
2050	Female, age 85, both hemispheres	217.3

Pedunculopontine tegmental nucleus
nTPM: 263.1

2334	Male, age 80, both hemispheres	293.3
2338	Male, age 61, both hemispheres	270.7
1921	Female, age 85, both hemispheres	225.2

Pontine nuclei
nTPM: 259.7

2319	Female, age 91, both hemispheres	313.5
2454	Male, age 74, left hemisphere	271.0
1968	Male, age 76, left hemisphere	266.4
2115	Male, age 80, left hemisphere	264.2
2109	Female, age 72, unknown	263.9
1863	Male, age 55, unknown	249.9
2727	Male, age 61, right hemisphere	233.7
2787	Female, age 85, both hemispheres	215.0

Pontine raphe nucleus
nTPM: 249.0

2853	Male, age 76, midline	250.5
2122	Female, age 85, midline	247.5

Posteroventral cochlear nucleus
nTPM: 337.3

2341	Male, age 80, both hemispheres	399.3
2135	Female, age 91, both hemispheres	395.2
2371	Male, age 61, both hemispheres	317.5
2070	Male, age 76, both hemispheres	303.8
2752	Female, age 85, both hemispheres	270.8

Principal sensory trigeminal nucleus
nTPM: 225.8

2367	Female, age 91, left hemisphere	248.8
2324	Male, age 76, both hemispheres	232.1
2158	Male, age 61, both hemispheres	231.5
2008	Male, age 80, left hemisphere	191.0

Reticular pontine nucleus, caudal
nTPM: 271.6

2559	Male, age 74, both hemispheres	306.0
2092	Male, age 76, both hemispheres	299.3
2457	Female, age 91, both hemispheres	296.9
2332	Male, age 80, right hemisphere	184.3

Reticular pontine nucleus, oral
nTPM: 267.5

2361	Male, age 74, both hemispheres	294.2
2366	Female, age 91, both hemispheres	290.1
1939	Male, age 80, both hemispheres	274.2
2167	Male, age 76, both hemispheres	264.4
2012	Female, age 85, both hemispheres	214.8

Reticulotegmental nucleus
nTPM: 267.8

2452	Male, age 74, both hemispheres	306.6
2322	Female, age 91, both hemispheres	277.7
2333	Male, age 80, both hemispheres	244.0
2325	Male, age 76, both hemispheres	242.9

Spinal trigeminal nucleus, oral
nTPM: 245.8

2164	Male, age 80, both hemispheres	260.0
1978	Male, age 76, both hemispheres	246.1
2737	Female, age 85, both hemispheres	231.1

Subcoeruleus area
nTPM: 278.7

2451	Male, age 74, both hemispheres	369.4
2369	Female, age 85, left hemisphere	339.7
2323	Female, age 91, left hemisphere	234.9
2089	Male, age 76, left hemisphere	226.4
1958	Male, age 80, both hemispheres	223.0

Superior olive
nTPM: 232.8

2020	Male, age 76, both hemispheres	303.3
2364	Male, age 74, right hemisphere	233.3
2561	Female, age 91, both hemispheres	228.9
1875	Female, age 85, both hemispheres	199.6
2329	Male, age 80, right hemisphere	198.8

Ventral periolivary nuclei
nTPM: 224.5

2023	Male, age 76, both hemispheres	296.5
2165	Male, age 80, both hemispheres	225.5
2794	Female, age 91, left hemisphere	224.4
2130	Female, age 85, both hemispheres	151.8

Ventrolateral tegmental area, A5 NE cell group
nTPM: 229.8

2456	Female, age 91, both hemispheres	249.5
2359	Male, age 61, both hemispheres	246.0
2161	Male, age 80, both hemispheres	245.3
2449	Male, age 74, both hemispheres	222.6
1959	Male, age 76, both hemispheres	221.9
2840	Female, age 85, both hemispheres	193.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	11.4

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 11.4

FF:10182-103D2	60 years, female	13.1
FF:10165-103B3	76 years, female	9.7

Pons
Scaled Tags Per Million: 8.6

FF:10033-101E6

18-54 years, mixed

8.6

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	942.6

Macaque sample

Sample description

nTPM

Pons
nTPM: 942.6

Samples: 2

Max nTPM: 969.9
Min nTPM: 915.2

Sample A		969.9
Sample B		915.2

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2334.3

Pig sample

Sample description

nTPM

Pons
nTPM: 2334.2

Samples: 3

Max nTPM: 2917.3
Min nTPM: 1615.9

Sample A	Female	2469.5
Sample B	Female	1615.9
Sample C	Male	2917.3

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	572.5

Mouse sample

Sample description

nTPM

Pons
nTPM: 572.5

Samples: 4

Max nTPM: 589.1
Min nTPM: 554.5

Sample A		589.1
Sample B		565.9
Sample C		580.4
Sample D		554.5