Brain tissue expression of RPL17 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	294.5	nTPM
FANTOM5:	34.6	Scaled Tags Per Million

Macaque:	391.7	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	294.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 294.1

2090	Male, age 80, both hemispheres	302.0
2188	Female, age 91, both hemispheres	298.6
2301	Female, age 85, both hemispheres	288.7
1984	Male, age 76, both hemispheres	287.1

Dorsal cochlear nucleus
nTPM: 282.4

2802	Male, age 74, right hemisphere	341.7
2187	Female, age 91, both hemispheres	287.9
2378	Male, age 80, both hemispheres	283.7
2370	Male, age 61, both hemispheres	260.3
2058	Male, age 76, both hemispheres	238.4

Dorsal tegmental nucleus
nTPM: 294.5

2358	Male, age 61, both hemispheres	332.7
2326	Male, age 74, both hemispheres	320.4
2083	Male, age 80, both hemispheres	292.8
1936	Male, age 76, left hemisphere	232.3

Dorsolateral tegmental area
nTPM: 290.4

2337	Male, age 61, both hemispheres	367.1
2654	Male, age 80, both hemispheres	308.0
2751	Female, age 85, both hemispheres	270.7
2360	Male, age 74, both hemispheres	270.4
2141	Male, age 76, both hemispheres	235.9

Kolliker-Fuse nucleus
nTPM: 294.5

2315	Male, age 76, right hemisphere	339.2
2163	Male, age 80, both hemispheres	277.5
2793	Female, age 91, left hemisphere	266.8

Lateral lemniscal nuclei
nTPM: 247.6

2169	Male, age 76, both hemispheres	283.8
2746	Female, age 85, left hemisphere	270.8
2036	Male, age 80, both hemispheres	229.6
2320	Female, age 91, left hemisphere	227.2
2453	Male, age 74, right hemisphere	226.8

Lateral parabrachial nucleus
nTPM: 285.8

2792	Male, age 76, both hemispheres	305.0
2013	Male, age 80, both hemispheres	300.4
2139	Female, age 85, right hemisphere	295.1
2790	Male, age 61, both hemispheres	242.7

Lateral vestibular nucleus
nTPM: 265.0

2311	Male, age 80, both hemispheres	311.3
2184	Male, age 76, both hemispheres	218.8

Locus coeruleus
nTPM: 256.0

2720	Male, age 74, both hemispheres	295.8
2123	Female, age 91, both hemispheres	273.7
2317	Female, age 72, unknown	258.0
2162	Male, age 80, both hemispheres	254.1
2788	Male, age 74, unknown	253.5
2014	Male, age 55, unknown	241.3
1980	Male, age 76, both hemispheres	215.2

Medial parabrachial nucleus
nTPM: 269.8

2170	Female, age 91, both hemispheres	325.7
2854	Male, age 80, both hemispheres	305.2
2463	Female, age 85, right hemisphere	248.2
2786	Male, age 76, both hemispheres	238.3
2156	Male, age 61, both hemispheres	231.8

Medial periolivary nuclei
nTPM: 265.4

2063	Male, age 76, both hemispheres	300.5
2081	Male, age 80, both hemispheres	270.9
2171	Female, age 85, both hemispheres	256.4
2791	Male, age 74, right hemisphere	251.2
2458	Female, age 91, both hemispheres	248.1

Motor facial nucleus
nTPM: 256.1

2062	Male, age 76, both hemispheres	295.4
2795	Female, age 91, both hemispheres	293.5
2697	Female, age 85, both hemispheres	256.8
2365	Male, age 74, right hemisphere	254.5
2126	Male, age 61, both hemispheres	237.8
2327	Male, age 80, both hemispheres	198.9

Motor trigeminal nucleus
nTPM: 243.9

2560	Male, age 74, both hemispheres	260.4
2335	Male, age 61, both hemispheres	250.3
2309	Male, age 76, both hemispheres	245.2
2321	Female, age 91, both hemispheres	236.4
2079	Male, age 80, both hemispheres	227.4

Nuclei of the trapezoid body
nTPM: 259.5

1983	Male, age 76, both hemispheres	363.2
2735	Female, age 85, both hemispheres	248.0
2166	Male, age 80, both hemispheres	242.7
2159	Male, age 61, both hemispheres	228.1
2368	Female, age 91, both hemispheres	215.7

Nucleus raphe magnus
nTPM: 256.3

2051	Male, age 76, both hemispheres	281.3
2160	Male, age 61, both hemispheres	264.6
2172	Female, age 85, both hemispheres	261.2
2459	Female, age 91, both hemispheres	252.5
2455	Male, age 74, both hemispheres	249.9
2328	Male, age 80, both hemispheres	228.5

Paramedian reticular nucleus
nTPM: 260.0

2050	Female, age 85, both hemispheres	274.0
2057	Male, age 80, both hemispheres	264.4
2052	Male, age 76, both hemispheres	259.9
2313	Male, age 61, both hemispheres	242.0

Pedunculopontine tegmental nucleus
nTPM: 286.8

2338	Male, age 61, both hemispheres	337.0
2334	Male, age 80, both hemispheres	284.8
1921	Female, age 85, both hemispheres	238.5

Pontine nuclei
nTPM: 284.1

2787	Female, age 85, both hemispheres	327.1
1863	Male, age 55, unknown	316.7
1968	Male, age 76, left hemisphere	307.6
2319	Female, age 91, both hemispheres	291.9
2727	Male, age 61, right hemisphere	266.1
2109	Female, age 72, unknown	263.6
2454	Male, age 74, left hemisphere	263.2
2115	Male, age 80, left hemisphere	236.6

Pontine raphe nucleus
nTPM: 267.3

2122	Female, age 85, midline	290.1
2853	Male, age 76, midline	244.6

Posteroventral cochlear nucleus
nTPM: 289.0

2341	Male, age 80, both hemispheres	343.1
2135	Female, age 91, both hemispheres	294.9
2371	Male, age 61, both hemispheres	294.2
2752	Female, age 85, both hemispheres	264.4
2070	Male, age 76, both hemispheres	248.5

Principal sensory trigeminal nucleus
nTPM: 231.8

2158	Male, age 61, both hemispheres	250.1
2367	Female, age 91, left hemisphere	242.4
2324	Male, age 76, both hemispheres	217.5
2008	Male, age 80, left hemisphere	217.2

Reticular pontine nucleus, caudal
nTPM: 247.4

2092	Male, age 76, both hemispheres	305.6
2559	Male, age 74, both hemispheres	254.5
2457	Female, age 91, both hemispheres	241.5
2332	Male, age 80, right hemisphere	187.9

Reticular pontine nucleus, oral
nTPM: 254.8

2167	Male, age 76, both hemispheres	276.7
1939	Male, age 80, both hemispheres	267.7
2366	Female, age 91, both hemispheres	262.6
2012	Female, age 85, both hemispheres	242.9
2361	Male, age 74, both hemispheres	223.9

Reticulotegmental nucleus
nTPM: 260.0

2452	Male, age 74, both hemispheres	295.7
2322	Female, age 91, both hemispheres	256.3
2325	Male, age 76, both hemispheres	245.7
2333	Male, age 80, both hemispheres	242.4

Spinal trigeminal nucleus, oral
nTPM: 250.1

2164	Male, age 80, both hemispheres	252.3
1978	Male, age 76, both hemispheres	249.1
2737	Female, age 85, both hemispheres	248.9

Subcoeruleus area
nTPM: 269.5

2451	Male, age 74, both hemispheres	323.2
1958	Male, age 80, both hemispheres	270.0
2369	Female, age 85, left hemisphere	268.5
2323	Female, age 91, left hemisphere	249.3
2089	Male, age 76, left hemisphere	236.3

Superior olive
nTPM: 246.0

2020	Male, age 76, both hemispheres	279.1
1875	Female, age 85, both hemispheres	258.6
2561	Female, age 91, both hemispheres	245.1
2364	Male, age 74, right hemisphere	227.0
2329	Male, age 80, right hemisphere	220.4

Ventral periolivary nuclei
nTPM: 260.8

2023	Male, age 76, both hemispheres	294.8
2130	Female, age 85, both hemispheres	266.2
2794	Female, age 91, left hemisphere	246.8
2165	Male, age 80, both hemispheres	235.4

Ventrolateral tegmental area, A5 NE cell group
nTPM: 268.7

2359	Male, age 61, both hemispheres	294.4
2161	Male, age 80, both hemispheres	284.6
2840	Female, age 85, both hemispheres	283.2
1959	Male, age 76, both hemispheres	266.2
2456	Female, age 91, both hemispheres	249.6
2449	Male, age 74, both hemispheres	233.9

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	34.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 34.6

FF:10182-103D2	60 years, female	36.8
FF:10165-103B3	76 years, female	32.4

Pons
Scaled Tags Per Million: 34.6

FF:10033-101E6

18-54 years, mixed

34.6

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	391.7

Macaque sample

Sample description

nTPM

Pons
nTPM: 391.8

Samples: 2

Max nTPM: 432.9
Min nTPM: 350.6

Sample A		432.9
Sample B		350.6