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BETA
  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • IMMUNE

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  • SOD2
EVOLUTIONARY CEREBRAL CORTEX Show tissue menu
BRAIN73 EYE4 ENDOCRINE TISSUES5 RESPIRATORY SYSTEM6 PROXIMAL DIGESTIVE TRACT5 GASTROINTESTINAL TRACT11 LIVER & GALLBLADDER4 PANCREAS1 KIDNEY & URINARY BLADDER4 MALE REPRODUCTIVE SYSTEM11 BREAST & FEMALE REPRODUCTIVE SYSTEM10 MUSCLE & VASCULAR TISSUE11 CONNECTIVE & SOFT TISSUE15 SKIN4 BONE MARROW & LYMPHOID TISSUES7
Select an organ to show its tissues
AMYGDALA ANGULAR GYRUS ANNECTANT GYRUS ANTERIOR CINGULATE GYRUS CAUDATE NUCLEUS CAUDATE PUTAMEN CEREBELLUM CEREBRAL CORTEX CHOROID PLEXUS CINGULATE CORTEX CLAUSTRUM CORPUS CALLOSUM CUNEUS DORSAL HIPPOCAMPUS DORSAL ROOT GANGLION DORSAL SPINAL CORD ENTORHINAL CORTEX FRONTAL CORTEX FUSIFORM GYRUS
GENICULATE NUCLEUS GLOBUS PALLIDUS GYRUS RECTUS HABENULA HIPPOCAMPAL FORMATION HYPOTHALAMUS HYPOTHALAMUS, ANTERIOR HYPOTHALAMUS, POSTERIOR INFERIOR FRONTAL GYRUS INFERIOR OCCIPITAL GYRUS INFERIOR TEMPORAL GYRUS INSULAR CORTEX LATERAL THALAMIC NUCLEI MEDULLA OBLONGATA MIDBRAIN MIDDLE FRONTAL GYRUS MIDDLE TEMPORAL GYRUS MOTOR AND PREFRONTAL CORTEX MOTOR CORTEX
OCCIPITAL CORTEX OCCIPITAL GYRUS OLFACTORY BULB ORBITAL GYRUS PERIAQUEDUCTAL GRAY PONS POSTCENTRAL GYRUS POSTERIOR CINGULATE CORTEX POSTERIOR PARAHIPPOCAMPAL GYRUS POSTERIOR THALAMUS PRECENTRAL GYRUS PREFRONTAL CORTEX PREOPTIC AREA PUTAMEN RETROSPLENIAL AND CINGULATE CORTEX RETROSPLENIAL CORTEX SEPTAL AREA SEPTUM SOMATOSENSORY CORTEX
SPINAL CORD SUBICULUM SUBSTANTIA NIGRA SUPERIOR COLLICULI SUPERIOR FRONTAL GYRUS SUPERIOR PARIETAL LOBULE SUPERIOR TEMPORAL GYRUS SUPRAMARGINAL GYRUS TEMPORAL CORTEX THALAMUS VENTRAL FOREBRAIN VENTRAL HIPPOCAMPUS VENTRAL PALLIDUM VENTRAL SPINAL CORD VISUAL CORTEX WHITE MATTER
CORNEA HARDERIAN GLAND LENS RETINA
ADRENAL GLAND PARATHYROID GLAND PINEAL GLAND PITUITARY GLAND THYROID GLAND
BRONCHUS LARYNX LUNG NASOPHARYNX OLFACTORY EPITHELIUM TRACHEA
ESOPHAGUS LIP ORAL MUCOSA SALIVARY GLAND TONGUE
CECUM COLON DUODENUM ILEUM JEJUNUM RECTUM SMALL INTESTINE STOMACH STOMACH (LOWER) STOMACH (MIDDLE) STOMACH (UPPER)
GALLBLADDER LIVER LIVER (LOBE 1) LIVER (LOBE 4)
PANCREAS
KIDNEY KIDNEY (CORTEX) KIDNEY (MEDULLA) URINARY BLADDER
BULBOURETHRAL GLAND DUCTUS DEFERENS EPIDIDYMIS MALE PREPUTIAL GLAND PENIS PROSTATE PROSTATE (ANTERIOR) PROSTATE (VENTRAL) SEMINAL VESICLE TESTIS URETHRAL GLAND
BREAST CERVIX CLITORIS ENDOMETRIUM FALLOPIAN TUBE FEMALE PREPUTIAL GLAND OVARY PLACENTA UTERUS VAGINA
AORTA DIAPHRAGM HEART ATRIUM HEART MUSCLE HEART VALVE HEART WALL PERIPHERAL VASCULATURE SKELETAL MUSCLE SMOOTH MUSCLE SMOOTH MUSCLE (INTESTINE) SMOOTH MUSCLE (UTERUS)
ABDOMINAL ADIPOSE TISSUE ADIPOSE TISSUE BROWN ADIPOSE TISSUE DURA MATER EAR CANAL EAR CARTILAGE JOINT CARTILAGE MENINGES ORBITAL ADIPOSE TISSUE PERICARDIUM PERITONEUM PLEURA SUBCUTANEOUS ADIPOSE TISSUE SYNOVIAL TISSUE VAGUS NERVE
EYE LID SKIN SKIN (BACK) SKIN (GROIN)
APPENDIX BLOOD, PBMC BONE MARROW LYMPH NODE SPLEEN THYMUS TONSIL
HumanMacaqueMouseRatPig
Protein evolution
Brain
Evolutionary methods
CEREBRAL CORTEX - Expression summary
Protein expression
Cerebral cortexi

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

h
m
l
n
Endothelial cells: Medium
Glial cells: Medium
Neuronal cells: High
Neuropil: Medium
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:53.1 nTPM
HPA:53.1 nTPM
HPA Brain:378.6 nTPM
HPA PFC Brain:18.0 nTPM
FANTOM5:318.0 Scaled Tags Per Million
Macaque:113.8 nTPM
Mouse:55.7 nTPM
Rat:72.2 nTPM
Pig:85.6 nTPM

CEREBRAL CORTEX - Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

Antibody HPA001814
Endothelial cells Medium
Glial cells Medium
Neuronal cells High
Neuropil Medium



CEREBRAL CORTEX - PROTEINTALKS DB MS
Median intensity 66104
Sample Intensity
Cerebral cortex_01
73217
Cerebral cortex_02
66691
Cerebral cortex_03
65517
Cerebral cortex_04
57754
Cerebral cortex_05
56847
Cerebral cortex_06
76894
Cerebral cortex_07
54742
Cerebral cortex_08
61566
Cerebral cortex_09
47704
Cerebral cortex_10
81605
Cerebral cortex_11
40498
Cerebral cortex_12
89657
Cerebral cortex_13
60955
Cerebral cortex_14
43721
Cerebral cortex_15
110471
Cerebral cortex_16
63762
Cerebral cortex_17
41343
Cerebral cortex_18
48342
Cerebral cortex_19
98698
Cerebral cortex_20
119595
Cerebral cortex_21
52370
Cerebral cortex_22
61046
Cerebral cortex_23
35766
Cerebral cortex_24
119717
Cerebral cortex_25
119719
Cerebral cortex_26
111632
Cerebral cortex_27
106338
Cerebral cortex_28
117547
Cerebral cortex_29
80947
Cerebral cortex_30
87062
Cerebral cortex_31
77790
Cerebral cortex_32
90429
Cerebral cortex_33
48474
Cerebral cortex_34
75798
Cerebral cortex_35
69330
Cerebral cortex_36
54505
Cerebral cortex_37
56688
Cerebral cortex_38
63562

CEREBRAL CORTEX - MANN MS
Median intensity 209244604
Replicate Intensity
Cerebral cortex_01
209244604
Cerebral cortex_02
195304258
Cerebral cortex_03
266212237

CEREBRAL CORTEX - HPA RNA-seqi

The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

Average nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

53.1
N/A
Male, age 5
Cerebral cortex sample 48
nTPM: 41.4
overview
Female, age 40
Cerebral cortex sample 105
nTPM: 24.8
Cell types%
Neuronal cells:
35

Glial cells and endothelial cells:
65

overview
Male, age 70
Cerebral cortex sample 106
nTPM: 93
Cell types%
Neuronal cells:
35

Glial cells and endothelial cells:
65


CEREBRAL CORTEX - HPA Brain Stereo-seq

CEREBRAL CORTEX - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

378.6
Sample id Sample description nTPM
Angular gyrus
nTPM: 157.0
2260 Female, age 72, left hemisphere 207.9
2221 Female, age 67, right hemisphere 197.3
2103 Male, age 75, left hemisphere 193.1
2265 Female, age 91, left hemisphere 171.0
2602 Female, age 94, right hemisphere 142.3
1790 Male, age 76, right hemisphere 129.8
2722 Male, age 61, left hemisphere 109.2
1866 Male, age 76, both hemispheres 105.3
Angular gyrus (white matter)
nTPM: 119.3
1920 Male, age 76, both hemispheres 119.3
Anterior cingulate cortex, supragenual-dorsal
nTPM: 164.0
2547 Male, age 74, left hemisphere 181.1
2478 Female, age 67, right hemisphere 174.3
1896 Female, age 85, right hemisphere 174.2
2472 Male, age 75, left hemisphere 145.5
2342 Female, age 94, right hemisphere 144.9
Anterior cingulate cortex, supragenual-ventral
nTPM: 149.8
1761 Male, age 74, left hemisphere 159.9
1950 Female, age 85, right hemisphere 157.9
1755 Female, age 94, right hemisphere 156.8
2538 Male, age 75, left hemisphere 142.0
2479 Female, age 67, right hemisphere 132.5
Anterior insular cortex, dorsal
nTPM: 156.7
2235 Female, age 91, right hemisphere 187.2
2506 Female, age 94, right hemisphere 153.8
2001 Male, age 76, right hemisphere 145.6
2670 Male, age 75, left hemisphere 140.1
Anterior insular cortex, ventral
nTPM: 148.8
1925 Female, age 91, left hemisphere 184.7
2262 Female, age 67, right hemisphere 161.4
2507 Female, age 94, left hemisphere 159.4
1852 Male, age 76, left hemisphere 154.3
2757 Male, age 61, right hemisphere 123.2
2596 Male, age 75, left hemisphere 110.1
Area parastriata, inferior
nTPM: 210.3
2234 Male, age 75, left hemisphere 624.8
1758 Female, age 72, right hemisphere 168.3
2421 Female, age 91, left hemisphere 164.2
2509 Female, age 94, left hemisphere 148.9
1760 Female, age 67, left hemisphere 136.2
1789 Male, age 76, right hemisphere 116.9
2268 Male, age 61, right hemisphere 113.0
Area parastriata, parietal
nTPM: 164.5
2236 Female, age 91, left hemisphere 297.5
2420 Male, age 75, left hemisphere 159.8
2680 Female, age 94, right hemisphere 155.4
2233 Male, age 61, right hemisphere 109.2
1785 Male, age 76, right hemisphere 100.5
Area parastriata, superior
nTPM: 378.6
2435 Male, age 61, left hemisphere 1518.8
1773 Female, age 91, left hemisphere 195.0
2604 Female, age 94, right hemisphere 165.1
2684 Female, age 67, left hemisphere 139.7
2419 Male, age 75, right hemisphere 130.2
2881 Male, age 76, left hemisphere 122.7
Area parastriata, temporal
nTPM: 130.5
2424 Female, age 67, left hemisphere 152.6
2681 Female, age 94, right hemisphere 133.5
2471 Male, age 75, left hemisphere 130.6
1804 Male, age 76, right hemisphere 120.0
2267 Male, age 61, right hemisphere 115.8
Area striata
nTPM: 174.9
2002 Female, age 91, right hemisphere 337.5
1753 Female, age 72, right hemisphere 182.5
2679 Female, age 94, right hemisphere 162.4
2427 Female, age 91, left hemisphere 135.8
1884 Male, age 76, left hemisphere 118.6
2417 Male, age 61, right hemisphere 112.5
Area striata (white matter)
nTPM: 143.5
2258 Female, age 91, left hemisphere 143.5
Claustrum
nTPM: 136.7
2196 Female, age 79, unknown 170.3
2198 Male, age 80, both hemispheres 155.4
2284 Female, age 91, both hemispheres 152.3
1956 Male, age 74, unknown 144.2
2645 Female, age 72, unknown 142.6
2392 Female, age 94, both hemispheres 130.3
2292 Female, age 85, both hemispheres 123.2
2491 Male, age 75, both hemispheres 121.6
2568 Male, age 61, both hemispheres 90.4
Corpus callosum, genu (white matter)
nTPM: 151.1
1934 Male, age 61, right hemisphere 202.6
1885 Female, age 94, left hemisphere 180.2
2771 Male, age 75, left hemisphere 157.1
1849 Female, age 91, right hemisphere 132.6
1886 Female, age 67, right hemisphere 124.3
1887 Male, age 76, left hemisphere 109.7
Corpus callosum, splenium (white matter)
nTPM: 230.3
2104 Male, age 75, left hemisphere 388.9
2847 Female, age 67, right hemisphere 189.6
1946 Male, age 76, left hemisphere 187.9
2238 Female, age 94, right hemisphere 154.9
Frontal eye field
nTPM: 146.3
2543 Male, age 74, left hemisphere 197.6
2761 Female, age 94, left hemisphere 148.7
2441 Male, age 75, left hemisphere 129.2
2147 Male, age 61, left hemisphere 109.9
Frontal operculum
nTPM: 154.1
2348 Male, age 75, left hemisphere 181.5
2781 Female, age 85, right hemisphere 147.7
2030 Male, age 61, right hemisphere 133.1
Fusiform gyrus
nTPM: 174.5
2431 Male, age 75, right hemisphere 254.0
2784 Female, age 85, left hemisphere 189.0
2074 Female, age 91, left hemisphere 186.8
2433 Female, age 72, left hemisphere 183.1
2112 Male, age 80, both hemispheres 144.7
2617 Female, age 94, left hemisphere 134.2
1807 Male, age 76, left hemisphere 130.0
Inferior frontal gyrus, opercular
nTPM: 143.3
2869 Male, age 74, left hemisphere 183.0
2873 Female, age 85, left hemisphere 156.9
2868 Male, age 75, right hemisphere 154.5
2871 Female, age 94, left hemisphere 154.1
2874 Female, age 85, right hemisphere 146.6
2872 Female, age 94, right hemisphere 143.7
2875 Female, age 67, left hemisphere 142.9
2867 Male, age 75, left hemisphere 122.8
2866 Male, age 61, right hemisphere 116.4
2865 Male, age 61, left hemisphere 112.0
Inferior parietal lobule
nTPM: 139.8
2599 Female, age 94, left hemisphere 154.7
2606 Female, age 67, right hemisphere 153.0
2418 Male, age 75, left hemisphere 140.7
2876 Male, age 76, right hemisphere 110.9
Inferior temporal gyrus
nTPM: 146.0
1965 Female, age 91, left hemisphere 171.2
1970 Female, age 85, right hemisphere 166.5
2430 Male, age 75, right hemisphere 158.3
1880 Male, age 80, right hemisphere 142.2
2689 Female, age 94, right hemisphere 122.4
1808 Male, age 76, left hemisphere 115.2
Intraparietal deep sulcus
nTPM: 134.0
2102 Female, age 91, left hemisphere 157.1
2600 Female, age 94, right hemisphere 152.5
2669 Male, age 75, left hemisphere 131.7
2230 Male, age 61, right hemisphere 127.2
2607 Female, age 67, right hemisphere 126.5
2798 Male, age 76, left hemisphere 108.8
Lingual gyrus
nTPM: 156.7
2688 Male, age 75, right hemisphere 198.7
2073 Female, age 85, left hemisphere 166.6
1893 Male, age 76, left hemisphere 148.8
2618 Female, age 94, left hemisphere 145.2
2838 Male, age 80, right hemisphere 123.9
Middle cingulate cortex
nTPM: 147.7
2357 Female, age 67, right hemisphere 175.5
2028 Female, age 85, left hemisphere 164.4
2633 Male, age 74, left hemisphere 147.8
2640 Female, age 94, right hemisphere 142.4
2539 Male, age 75, left hemisphere 108.6
Middle temporal gyrus
nTPM: 140.7
2034 Female, age 91, right hemisphere 171.9
1819 Male, age 80, right hemisphere 152.2
2616 Female, age 94, left hemisphere 143.1
2611 Male, age 75, right hemisphere 129.6
1799 Male, age 76, left hemisphere 106.6
Occipital cortex
nTPM: 120.6
2608 Female, age 67, both hemispheres 141.2
2677 Female, age 67, right hemisphere 124.3
2426 Male, age 75, midline 122.2
2470 Male, age 75, right hemisphere 115.3
1842 Male, age 76, right hemisphere 100.1
Occipital cortex (white matter)
nTPM: 186.5
2259 Male, age 75, midline 237.3
2257 Female, age 67, both hemispheres 135.8
Olfactory area
nTPM: 165.0
2756 Female, age 67, right hemisphere 210.0
2222 Female, age 67, right hemisphere 206.7
1805 Female, age 85, right hemisphere 158.2
2352 Female, age 94, right hemisphere 142.0
2440 Male, age 75, left hemisphere 138.3
2542 Male, age 74, left hemisphere 134.5
Olfactory tubercle
nTPM: 167.5
1998 Female, age 91, both hemispheres 185.3
1846 Male, age 80, right hemisphere 178.5
2487 Female, age 94, left hemisphere 156.2
2856 Male, age 75, right hemisphere 150.0
Orbitofrontal gyrus, anterior
nTPM: 143.2
2863 Female, age 85, right hemisphere 169.8
2862 Female, age 85, left hemisphere 132.7
2864 Female, age 67, left hemisphere 127.1
Paracentral lobule, anterior
nTPM: 165.9
1776 Female, age 85, right hemisphere 189.2
2474 Male, age 74, left hemisphere 176.5
2340 Female, age 67, right hemisphere 175.4
1754 Male, age 75, left hemisphere 163.4
2638 Female, age 94, right hemisphere 150.8
1926 Male, age 61, left hemisphere 139.8
Paracentral lobule, posterior
nTPM: 144.0
1775 Female, age 85, right hemisphere 179.2
2551 Female, age 94, right hemisphere 159.9
1764 Male, age 74, right hemisphere 157.7
2345 Male, age 61, left hemisphere 121.9
2446 Male, age 75, left hemisphere 101.4
Parahippocampal cortex (white matter)
nTPM: 141.4
2157 Female, age 91, both hemispheres 141.4
Parietal operculum
nTPM: 155.8
2719 Male, age 75, left hemisphere 159.8
2552 Female, age 94, right hemisphere 157.3
1763 Male, age 74, left hemisphere 155.3
2356 Female, age 67, right hemisphere 150.9
Parieto-insular cortex
nTPM: 144.0
1976 Female, age 91, right hemisphere 196.4
2508 Female, age 94, right hemisphere 162.1
2671 Male, age 75, left hemisphere 141.1
2232 Male, age 61, right hemisphere 114.7
2831 Male, age 76, right hemisphere 105.6
Parieto-occipital transitional area
nTPM: 133.3
2468 Male, age 75, left hemisphere 165.1
2674 Female, age 94, right hemisphere 151.2
1784 Male, age 76, right hemisphere 119.4
2683 Female, age 67, left hemisphere 118.8
2270 Male, age 61, right hemisphere 112.2
Parieto-temporal junction (white matter)
nTPM: 114.7
1999 Female, age 67, right hemisphere 124.3
2469 Male, age 75, right hemisphere 124.3
1935 Female, age 94, right hemisphere 117.6
2770 Female, age 91, right hemisphere 114.5
2121 Male, age 76, left hemisphere 103.7
2774 Male, age 61, right hemisphere 103.7
Piriform cortex
nTPM: 285.9
2347 Male, age 75, right hemisphere 442.9
2153 Female, age 85, left hemisphere 129.0
Postcentral gyrus
nTPM: 145.2
2533 Male, age 75, right hemisphere 145.2
Postcentral gyrus, dorsal
nTPM: 160.7
1836 Female, age 85, right hemisphere 212.8
2477 Female, age 94, right hemisphere 181.6
2544 Male, age 74, left hemisphere 152.7
2350 Male, age 75, left hemisphere 143.5
2339 Female, age 67, right hemisphere 143.4
2151 Male, age 61, left hemisphere 130.2
Postcentral gyrus, middle
nTPM: 155.3
2146 Female, age 67, right hemisphere 197.1
1897 Female, age 85, right hemisphere 185.0
2545 Male, age 74, left hemisphere 156.5
2444 Male, age 75, left hemisphere 119.6
2248 Male, age 61, left hemisphere 118.5
Postcentral gyrus, ventral
nTPM: 145.1
2024 Female, age 85, right hemisphere 150.5
2445 Male, age 75, left hemisphere 147.0
2836 Female, age 94, right hemisphere 137.7
Posterior cingulate cortex
nTPM: 143.3
1759 Male, age 74, right hemisphere 157.8
2553 Female, age 94, right hemisphere 152.0
2473 Male, age 75, left hemisphere 120.2
Posterior cingulate cortex, dorsal
nTPM: 144.1
2076 Female, age 85, right hemisphere 169.1
2641 Female, age 94, right hemisphere 163.9
2556 Female, age 67, right hemisphere 140.6
2634 Male, age 74, left hemisphere 139.1
2540 Male, age 75, right hemisphere 131.6
2343 Male, age 61, left hemisphere 120.4
Posterior cingulate cortex, ventral
nTPM: 143.6
1994 Female, age 85, right hemisphere 181.7
1762 Female, age 94, right hemisphere 150.7
2635 Male, age 74, left hemisphere 149.7
2448 Female, age 67, right hemisphere 145.4
2541 Male, age 75, right hemisphere 119.4
2346 Male, age 61, left hemisphere 114.6
Posterior insular cortex
nTPM: 135.7
2832 Female, age 91, right hemisphere 163.8
2511 Female, age 67, right hemisphere 155.4
2603 Female, age 94, left hemisphere 142.4
2597 Male, age 75, left hemisphere 137.2
2231 Male, age 61, left hemisphere 110.8
1823 Male, age 76, right hemisphere 104.4
Precentral gyrus
nTPM: 128.8
2557 Male, age 75, right hemisphere 128.8
Precentral gyrus, dorsal
nTPM: 149.3
2476 Female, age 94, right hemisphere 166.1
1756 Male, age 74, left hemisphere 159.3
2354 Female, age 67, right hemisphere 143.3
2442 Male, age 75, left hemisphere 128.7
Precentral gyrus, middle
nTPM: 156.0
1969 Female, age 67, right hemisphere 206.6
2475 Male, age 74, right hemisphere 179.0
2549 Female, age 94, right hemisphere 147.4
1909 Male, age 61, left hemisphere 132.8
2443 Male, age 75, left hemisphere 114.3
Precentral gyrus, ventral
nTPM: 148.9
2678 Male, age 74, left hemisphere 167.2
2550 Female, age 94, right hemisphere 158.9
2662 Female, age 67, right hemisphere 151.1
2630 Male, age 75, left hemisphere 118.5
Precuneus
nTPM: 138.1
2510 Female, age 67, right hemisphere 166.8
2673 Female, age 94, right hemisphere 151.1
2467 Male, age 75, right hemisphere 148.0
1780 Female, age 91, right hemisphere 122.5
1782 Male, age 76, right hemisphere 120.7
2594 Male, age 61, left hemisphere 119.2
Premotor cortex, dorsal
nTPM: 147.9
1878 Female, age 85, right hemisphere 177.4
2631 Male, age 74, left hemisphere 147.1
2554 Female, age 67, right hemisphere 146.2
2027 Male, age 61, left hemisphere 135.6
2536 Male, age 75, left hemisphere 133.0
Premotor cortex, ventral
nTPM: 152.7
1881 Female, age 85, right hemisphere 179.3
1777 Female, age 67, left hemisphere 178.7
2637 Female, age 94, right hemisphere 155.1
1757 Male, age 74, left hemisphere 151.1
2349 Male, age 75, left hemisphere 130.1
1779 Male, age 61, left hemisphere 121.7
Retrosplenial cortex
nTPM: 188.7
1951 Male, age 61, right hemisphere 214.5
1914 Male, age 76, right hemisphere 199.1
2675 Female, age 94, left hemisphere 152.6
Somatomor cortex, precentral gyrus (white matter)
nTPM: 142.3
2439 Male, age 75, right hemisphere 142.3
Somatosensory cortex, postcentral gyrus, ventral (white matter)
nTPM: 137.7
2623 Male, age 75, right hemisphere 137.7
Subcentral gyrus, S2
nTPM: 151.3
2762 Male, age 74, left hemisphere 174.9
1964 Female, age 85, right hemisphere 173.4
2839 Female, age 94, right hemisphere 150.3
2351 Male, age 75, left hemisphere 148.9
2555 Female, age 67, right hemisphere 135.1
2072 Male, age 61, left hemisphere 125.2
Superior parietal lobule
nTPM: 144.6
1992 Female, age 91, right hemisphere 181.4
2672 Female, age 94, right hemisphere 144.4
2605 Female, age 67, right hemisphere 144.3
2229 Male, age 61, right hemisphere 127.7
1800 Male, age 76, right hemisphere 125.1
Superior temporal gyrus
nTPM: 134.1
1844 Female, age 91, left hemisphere 176.5
2615 Female, age 94, left hemisphere 147.4
2025 Male, age 80, right hemisphere 140.5
2687 Male, age 75, right hemisphere 104.9
1843 Male, age 76, left hemisphere 101.3
Supplementary motor cortex
nTPM: 142.8
2548 Female, age 94, right hemisphere 176.6
1993 Male, age 61, left hemisphere 139.3
2632 Male, age 74, left hemisphere 132.1
2537 Male, age 75, left hemisphere 123.1
Supramarginal gyrus
nTPM: 144.3
2513 Female, age 72, left hemisphere 173.8
1991 Female, age 91, right hemisphere 168.5
2601 Female, age 94, left hemisphere 144.9
1798 Male, age 76, right hemisphere 130.8
2415 Male, age 61, left hemisphere 103.2
Temporal pole
nTPM: 155.2
2518 Male, age 75, right hemisphere 183.6
1853 Female, age 85, right hemisphere 168.2
1832 Female, age 91, left hemisphere 157.0
2612 Female, age 94, left hemisphere 138.9
1826 Male, age 76, right hemisphere 128.2
Temporal white matter
nTPM: 145.8
1801 Male, age 76, left hemisphere 207.3
2524 Female, age 85, left hemisphere 141.0
2254 Male, age 75, right hemisphere 130.6
2736 Female, age 91, right hemisphere 127.8
2523 Female, age 94, left hemisphere 122.6
Temporo-insular cortex, parainsular gyrus
nTPM: 152.3
2264 Female, age 91, right hemisphere 231.0
2598 Male, age 75, left hemisphere 202.2
2512 Female, age 67, right hemisphere 132.3
1802 Male, age 76, left hemisphere 131.4
2676 Female, age 94, right hemisphere 123.9
2416 Male, age 61, right hemisphere 93.2
Temporo-occipital transitional zone
nTPM: 141.8
2251 Female, age 85, right hemisphere 152.5
1793 Male, age 80, right hemisphere 146.4
1900 Male, age 76, left hemisphere 126.4
Transversal temporal gyrus, anterior
nTPM: 142.4
1888 Female, age 91, left hemisphere 178.4
2522 Female, age 94, left hemisphere 149.2
1910 Male, age 80, right hemisphere 149.1
2610 Male, age 75, right hemisphere 127.7
1809 Male, age 76, right hemisphere 107.4
Transversal temporal gyrus, posterior
nTPM: 148.8
1967 Female, age 91, right hemisphere 261.9
2614 Female, age 94, left hemisphere 141.9
2833 Male, age 80, right hemisphere 134.7
2520 Male, age 75, right hemisphere 106.1
1922 Male, age 76, left hemisphere 99.3

CEREBRAL CORTEX - HPA PFC Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

18.0
Sample id Sample description nTPM
Anterior cingulate gyrus, pregenual-dorsal
nTPM: 11.7
1510 Male, age 61, left hemisphere 17.5
1517 Female, age 67, left hemisphere 15.0
1512 Male, age 75, left hemisphere 14.1
1515 Female, age 94, right hemisphere 12.4
1513 Male, age 74, left hemisphere 12.0
1518 Female, age 67, right hemisphere 10.2
1511 Male, age 61, right hemisphere 10.0
1514 Male, age 74, right hemisphere 9.3
1516 Female, age 85, left hemisphere 4.4
Anterior cingulate gyrus, pregenual-ventral
nTPM: 16.2
1520 Male, age 75, right hemisphere 30.2
1519 Male, age 61, left hemisphere 17.2
1522 Male, age 74, right hemisphere 13.5
1521 Male, age 74, left hemisphere 11.6
1523 Female, age 67, left hemisphere 8.2
Anterior cingulate gyrus, subgenual
nTPM: 12.5
1526 Male, age 75, right hemisphere 22.2
1525 Male, age 75, left hemisphere 19.1
1524 Male, age 61, left hemisphere 13.2
1528 Male, age 74, right hemisphere 12.6
1527 Male, age 74, left hemisphere 9.2
1530 Female, age 67, right hemisphere 5.8
1529 Female, age 85, left hemisphere 5.4
Dorsolateral prefrontal cortex
nTPM: 10.2
1444 Male, age 75, left hemisphere 15.7
1445 Male, age 75, right hemisphere 13.5
1446 Male, age 74, right hemisphere 10.0
1448 Female, age 94, right hemisphere 9.1
1450 Female, age 67, right hemisphere 8.3
1449 Female, age 85, right hemisphere 7.6
1447 Female, age 94, left hemisphere 7.1
Dorsomedial prefrontal cortex
nTPM: 12.4
1440 Male, age 61, right hemisphere 22.3
1442 Male, age 75, right hemisphere 12.5
1439 Male, age 61, left hemisphere 9.6
1441 Male, age 75, left hemisphere 9.6
1443 Female, age 67, right hemisphere 8.2
Frontomarginal cortex
nTPM: 10.0
1465 Male, age 61, left hemisphere 18.6
1467 Male, age 75, right hemisphere 12.8
1466 Male, age 61, right hemisphere 12.2
1469 Female, age 94, left hemisphere 10.1
1473 Female, age 67, right hemisphere 9.6
1468 Male, age 74, left hemisphere 9.3
1470 Female, age 94, right hemisphere 8.2
1471 Female, age 85, left hemisphere 6.1
1472 Female, age 67, left hemisphere 2.8
Frontopolar cortex
nTPM: 12.4
1458 Male, age 61, left hemisphere 27.0
1460 Male, age 75, left hemisphere 16.7
1459 Male, age 61, right hemisphere 12.0
1461 Male, age 75, right hemisphere 11.6
1462 Female, age 94, left hemisphere 9.0
1464 Female, age 67, right hemisphere 5.2
1463 Female, age 67, left hemisphere 5.1
Gyrus rectus
nTPM: 13.0
1477 Male, age 75, right hemisphere 29.0
1475 Male, age 61, right hemisphere 19.9
1479 Female, age 94, right hemisphere 12.0
1474 Male, age 61, left hemisphere 11.3
1476 Male, age 75, left hemisphere 11.3
1481 Female, age 67, left hemisphere 9.1
1478 Female, age 94, left hemisphere 6.9
1480 Female, age 85, left hemisphere 4.7
Inferior frontal gyrus, orbital
nTPM: 18.0
1507 Female, age 85, left hemisphere 50.7
1505 Male, age 74, right hemisphere 31.7
1503 Male, age 75, right hemisphere 24.8
1502 Male, age 75, left hemisphere 15.0
1501 Male, age 61, right hemisphere 11.6
1500 Male, age 61, left hemisphere 11.3
1508 Female, age 85, right hemisphere 10.2
1509 Female, age 67, right hemisphere 8.9
1506 Female, age 94, left hemisphere 8.5
1504 Male, age 74, left hemisphere 7.5
Inferior frontal gyrus, triangular
nTPM: 12.0
1542 Male, age 61, left hemisphere 19.2
1545 Male, age 74, right hemisphere 14.7
1547 Female, age 85, left hemisphere 13.6
1544 Male, age 75, right hemisphere 12.3
1548 Female, age 85, right hemisphere 12.2
1549 Female, age 67, left hemisphere 9.9
1546 Female, age 94, right hemisphere 9.6
1543 Male, age 61, right hemisphere 4.2
Orbitofrontal gyrus, lateral
nTPM: 11.9
1494 Male, age 75, left hemisphere 19.6
1493 Male, age 61, right hemisphere 15.3
1495 Female, age 94, left hemisphere 13.4
1497 Female, age 85, left hemisphere 9.5
1496 Female, age 94, right hemisphere 9.1
1499 Female, age 67, right hemisphere 9.0
1498 Female, age 85, right hemisphere 7.4
Orbitofrontal gyrus, medial
nTPM: 9.5
1483 Male, age 75, left hemisphere 20.6
1484 Male, age 75, right hemisphere 20.3
1488 Female, age 94, right hemisphere 13.3
1487 Female, age 94, left hemisphere 9.1
1482 Male, age 61, left hemisphere 6.5
1490 Female, age 85, right hemisphere 6.4
1489 Female, age 85, left hemisphere 6.2
1485 Male, age 74, left hemisphere 5.9
1486 Male, age 74, right hemisphere 5.6
1491 Female, age 67, left hemisphere 5.4
1492 Female, age 67, right hemisphere 4.8
Orbitofrontal gyrus, posterior
nTPM: 10.7
1537 Female, age 94, right hemisphere 19.2
1534 Male, age 75, right hemisphere 18.1
1532 Male, age 61, right hemisphere 15.6
1533 Male, age 75, left hemisphere 12.2
1531 Male, age 61, left hemisphere 10.4
1536 Female, age 94, left hemisphere 9.7
1535 Male, age 74, left hemisphere 8.7
1541 Female, age 67, right hemisphere 6.6
1540 Female, age 67, left hemisphere 6.3
1539 Female, age 85, right hemisphere 5.8
1538 Female, age 85, left hemisphere 5.6
Subcallosal gyrus
nTPM: 7.9
1550 Male, age 61, left hemisphere 10.5
1553 Male, age 75, right hemisphere 9.5
1556 Female, age 94, left hemisphere 9.4
1552 Male, age 75, left hemisphere 9.1
1559 Female, age 85, right hemisphere 8.7
1560 Female, age 67, left hemisphere 7.7
1551 Male, age 61, right hemisphere 7.6
1561 Female, age 67, right hemisphere 7.2
1557 Female, age 94, right hemisphere 7.0
1558 Female, age 85, left hemisphere 6.9
1555 Male, age 74, right hemisphere 5.3
1554 Male, age 74, left hemisphere 5.2
Superior frontal gyrus
nTPM: 7.3
1563 Male, age 61, right hemisphere 15.2
1565 Male, age 75, right hemisphere 9.4
1562 Male, age 61, left hemisphere 7.5
1564 Male, age 75, left hemisphere 7.2
1568 Female, age 94, right hemisphere 7.0
1566 Male, age 74, right hemisphere 6.9
1571 Female, age 67, right hemisphere 5.4
1567 Female, age 94, left hemisphere 5.1
1570 Female, age 85, right hemisphere 5.0
1569 Female, age 85, left hemisphere 3.9
Temporal cortex
nTPM: 6.1
1593 Male, age 74, right hemisphere 9.1
1591 Male, age 75, right hemisphere 6.7
1592 Male, age 74, left hemisphere 6.0
1594 Female, age 94, left hemisphere 5.9
1590 Male, age 61, right hemisphere 5.8
1596 Female, age 85, right hemisphere 5.2
1595 Female, age 94, right hemisphere 4.1
Ventrolateral prefrontal cortex
nTPM: 9.0
1451 Male, age 75, right hemisphere 13.7
1452 Male, age 74, left hemisphere 11.9
1453 Male, age 74, right hemisphere 11.8
1454 Female, age 94, left hemisphere 8.5
1455 Female, age 85, right hemisphere 6.5
1457 Female, age 67, right hemisphere 5.5
1456 Female, age 67, left hemisphere 5.0
Ventromedial prefrontal cortex
nTPM: 11.3
1434 Male, age 75, right hemisphere 27.9
1438 Female, age 67, left hemisphere 13.1
1435 Female, age 94, right hemisphere 9.9
1437 Female, age 85, right hemisphere 9.1
1432 Male, age 61, left hemisphere 8.1
1433 Male, age 61, right hemisphere 7.4
1436 Female, age 85, left hemisphere 3.5

CEREBRAL CORTEX - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

318.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Occipital cortex
Scaled Tags Per Million: 318.0
FF:10163-103B1 76 years, female 318.0
Postcentral gyrus
Scaled Tags Per Million: 65.5
FF:10032-101E5 44-52 years, mixed 65.5
Frontal lobe
Scaled Tags Per Million: 58.7
FF:10040-101F4 32-61 years, mixed 58.7
Insula
Scaled Tags Per Million: 67.2
FF:10039-101F3 20-68 years, mixed 67.2
Medial frontal gyrus
Scaled Tags Per Million: 201.3
FF:10150-102I6 76 years, female 201.3
Medial temporal gyrus
Scaled Tags Per Million: 134.7
FF:10156-103A3 76 years, female 172.9
FF:10183-103D3 60 years, female 96.5
Occipital lobe
Scaled Tags Per Million: 68.4
FF:10076-102A4 27 years, male 68.4
Occipital pole
Scaled Tags Per Million: 61.2
FF:10036-101E9 22-68 years, mixed 61.2
Paracentral gyrus
Scaled Tags Per Million: 78.5
FF:10035-101E8 22-69 years, mixed 78.5
Parietal lobe
Scaled Tags Per Million: 135.6
FF:10157-103A4 76 years, female 217.7
FF:10171-103B9 60 years, female 114.5
FF:10034-101E7 35-89 years, mixed 74.7
Temporal lobe
Scaled Tags Per Million: 62.3
FF:10031-101E4 32-61 years, mixed 62.3

CEREBRAL CORTEX - Macaque RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

113.8
Macaque sample Sample description nTPM
Angular gyrus
nTPM: 113.3
Samples: 1

Max nTPM: 113.3
Min nTPM: 113.3
Sample A 113.3
Claustrum
nTPM: 83.8
Samples: 1

Max nTPM: 83.8
Min nTPM: 83.8
Sample B 83.8
Fusiform gyrus
nTPM: 86.8
Samples: 2

Max nTPM: 94.4
Min nTPM: 79.1
Sample A 79.1
Sample B 94.4
Inferior temporal gyrus
nTPM: 81.2
Samples: 2

Max nTPM: 93.2
Min nTPM: 69.1
Sample A 69.1
Sample B 93.2
Middle temporal gyrus
nTPM: 101.3
Samples: 2

Max nTPM: 108.7
Min nTPM: 93.9
Sample A 108.7
Sample B 93.9
Postcentral gyrus
nTPM: 106.1
Samples: 2

Max nTPM: 123.3
Min nTPM: 88.9
Sample A 88.9
Sample B 123.3
Posterior cingulate cortex
nTPM: 95.0
Samples: 2

Max nTPM: 96.9
Min nTPM: 93.0
Sample A 93.0
Sample B 96.9
Precentral gyrus
nTPM: 113.8
Samples: 3

Max nTPM: 124.0
Min nTPM: 107.4
Sample A 110.0
Sample B 124.0
Sample C 107.4
Superior parietal lobule
nTPM: 100.8
Samples: 2

Max nTPM: 103.8
Min nTPM: 97.8
Sample A 97.8
Sample B 103.8
Superior temporal gyrus
nTPM: 85.0
Samples: 2

Max nTPM: 87.0
Min nTPM: 83.0
Sample A 83.0
Sample B 87.0
Supramarginal gyrus
nTPM: 105.4
Samples: 2

Max nTPM: 106.0
Min nTPM: 104.8
Sample A 106.0
Sample B 104.8
Gyrus rectus
nTPM: 85.9
Samples: 2

Max nTPM: 88.6
Min nTPM: 83.2
Sample A 83.2
Sample B 88.6
Insular cortex
nTPM: 82.9
Samples: 2

Max nTPM: 85.9
Min nTPM: 79.8
Sample A 85.9
Sample B 79.8
Superior frontal gyrus
nTPM: 108.4
Samples: 2

Max nTPM: 119.1
Min nTPM: 97.6
Sample A 97.6
Sample B 119.1

CEREBRAL CORTEX - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

85.6
Pig sample Sample description nTPM
Occipital cortex
nTPM: 77.9
Samples: 4

Max nTPM: 86.9
Min nTPM: 68.1
Sample A Female 86.9
Sample B Female 68.1
Sample C Male 85.6
Sample D Male 71.0
Retrosplenial cortex
nTPM: 68.3
Samples: 4

Max nTPM: 78.9
Min nTPM: 62.2
Sample A Female 69.4
Sample B Female 62.2
Sample C Male 78.9
Sample D Male 62.8
Cingulate cortex
nTPM: 71.6
Samples: 4

Max nTPM: 81.5
Min nTPM: 58.6
Sample A Female 81.5
Sample B Female 58.6
Sample C Male 78.2
Sample D Male 67.9
Insular cortex
nTPM: 60.1
Samples: 4

Max nTPM: 74.9
Min nTPM: 49.6
Sample A Female 74.9
Sample B Female 49.6
Sample C Male 62.2
Sample D Male 53.8
Motor cortex
nTPM: 80.2
Samples: 4

Max nTPM: 91.7
Min nTPM: 68.5
Sample A Female 89.3
Sample B Female 68.5
Sample C Male 91.7
Sample D Male 71.1
Prefrontal cortex
nTPM: 71.6
Samples: 4

Max nTPM: 76.3
Min nTPM: 68.7
Sample A Female 76.3
Sample B Female 70.2
Sample C Male 71.0
Sample D Male 68.7
Somatosensory cortex
nTPM: 85.6
Samples: 3

Max nTPM: 97.7
Min nTPM: 73.7
Sample B Female 73.7
Sample C Male 85.3
Sample D Male 97.7
Temporal cortex
nTPM: 68.5
Samples: 3

Max nTPM: 72.2
Min nTPM: 63.2
Sample A Female 72.2
Sample B Female 63.2
Sample D Male 70.1

CEREBRAL CORTEX - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

55.7
Mouse sample Sample description nTPM
Motor and prefrontal cortex
nTPM: 45.7
Samples: 4

Max nTPM: 49.0
Min nTPM: 42.0
Sample A 49.0
Sample B 45.4
Sample C 46.5
Sample D 42.0
Retrosplenial and cingulate cortex
nTPM: 55.7
Samples: 3

Max nTPM: 59.8
Min nTPM: 49.6
Sample A 49.6
Sample B 59.8
Sample C 57.7
Somatosensory cortex
nTPM: 40.7
Samples: 4

Max nTPM: 44.9
Min nTPM: 37.6
Sample A 44.9
Sample B 38.6
Sample C 41.8
Sample D 37.6
Visual cortex
nTPM: 49.5
Samples: 4

Max nTPM: 55.5
Min nTPM: 46.5
Sample A 48.2
Sample B 46.5
Sample C 55.5
Sample D 47.8

CEREBRAL CORTEX - Rat RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

72.2
Rat sample Sample description nTPM
Occipital cortex
nTPM: 70.2
Samples: 4

Max nTPM: 77.7
Min nTPM: 65.5
Sample A 65.7
Sample A 65.5
Sample A 77.7
Sample A 71.9
Retrosplenial and cingulate cortex
nTPM: 72.2
Samples: 4

Max nTPM: 73.4
Min nTPM: 70.8
Sample A 73.4
Sample A 73.4
Sample B 70.8
Sample A 71.1
Somatosensory cortex
nTPM: 72.1
Samples: 4

Max nTPM: 76.0
Min nTPM: 69.4
Sample A 70.3
Sample A 76.0
Sample A 72.7
Sample A 69.4

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