PDK2

GENERAL INFORMATION

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Gene name

PDK2

Gene description

Pyruvate dehydrogenase kinase, isozyme 2

Protein class

Enzymes
Mitochondrial proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA008287
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PDK2 (HGNC Symbol)

Synonyms

PDHK2

Description

Pyruvate dehydrogenase kinase, isozyme 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

17

Cytoband

q21.33

Chromosome location (bp)

50094737 - 50112152

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005882 (version 78.38)

Entrez gene

5164

UniProt

Q15119 (UniProt - Evidence at protein level)

neXtProt

NX_Q15119

Antibodypedia

PDK2 antibodies


PROTEIN BROWSER

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ENST00000007708
 
ENST00000503176
 
ENST00000503614
 
ENST00000505440
 
ENST00000508030
 
ENST00000510219
 
ENST00000512238
 
ENST00000614357
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDK2-001 ENSP00000420927
ENST00000503176
Q15119
Show all »
Show » Show » 407 46.2 No 0
PDK2-003 ENSP00000007708
ENST00000007708
Q15119
Show all »
Show » Show » 343 38.9 No 0
PDK2-008 ENSP00000427682
ENST00000508030
D6RHG2
Show all »
Show » 129 14.9 No 0
PDK2-009 ENSP00000425265
ENST00000503614
D6RDN9
Show all »
Show » 259 29.4 No 0
PDK2-012 ENSP00000425615
ENST00000505440
D6RJH7
Show all »
Show » 141 16.2 No 0
PDK2-014 ENSP00000421178
ENST00000512238
D6RGV8
Show all »
Show » 98 11.5 No 0
PDK2-016 ENSP00000423310
ENST00000510219
D6R983
Show all »
Show » 160 18.6 No 0
PDK2-201 ENSP00000481915
ENST00000614357
Q15119
Show all »
Show » Show » 343 38.9 No 0