CDKL3

GENERAL INFORMATION

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Gene name

CDKL3

Gene description

Cyclin-dependent kinase-like 3

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in testis. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA007446 , HPA027751
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

CDKL3 (HGNC Symbol)

Synonyms

NKIAMRE

Description

Cyclin-dependent kinase-like 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.1

Chromosome location (bp)

134286350 - 134371047

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000006837 (version 78.38)

Entrez gene

51265

UniProt

Q8IVW4 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IVW4

Antibodypedia

CDKL3 antibodies


PROTEIN BROWSER

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ENST00000265334
 
ENST00000518990
 
ENST00000521118
 
ENST00000521755
 
ENST00000523054
 
ENST00000523832
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKL3-001 ENSP00000265334
ENST00000265334
Q8IVW4
Show all »
Show » Show » 592 67.5 No 0
CDKL3-002 ENSP00000428500
ENST00000523054
B4DX41
Show all »
Show » Show » 401 45.1 No 0
CDKL3-006 ENSP00000428689
ENST00000521118
E7ET86
Show all »
Show » Show » 590 67.2 No 0
CDKL3-008 ENSP00000430496
ENST00000523832
Q8IVW4
Show all »
Show » Show » 455 51.6 No 0
CDKL3-010 ENSP00000427964
ENST00000521755
E5RFT9
Show all »
Show » 44 4.9 No 0
CDKL3-012 ENSP00000427836
ENST00000518990
Show » 73 8.2 No 0