The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Glandular cells generally displayed strong positivity in luminal membranes often combined with additional weak cytoplasmic staining. Cilia showed distinct immunoreactivity. Remaining normal cell types were in general negative.
Moderate cytoplasmic and membranous positivity was observed in bronchus, intestinal glands, renal tubules, breast, smooth muscle and cardiomyocytes. Skeletal myocytes, luminal membrane in pancreas and salivary gland were strongly stained. Remaining normal tissues were weakly stained or negative.
Moderate to strong cytoplasmic and membranous positivity was observes in the majority of normal tissues. Distinct staining was often observed in luminal membranes e.g. bile ducts in liver and intercalated ducts in pancreas. Bowmans capsule in the kidney were strongly stained. Cells in CNS and lymphoid tissues were weakly stained or negative.