MAPK8IP2

GENERAL INFORMATION

? »

Gene name

MAPK8IP2

Gene description

Mitogen-activated protein kinase 8 interacting protein 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in CNS.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA034780
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

? »

Gene name

MAPK8IP2 (HGNC Symbol)

Synonyms

IB2, JIP2, PRKM8IPL

Description

Mitogen-activated protein kinase 8 interacting protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]

Chromosome

22

Cytoband

q13.33

Chromosome location (bp)

50600685 - 50613981

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008735 (version 78.38)

Entrez gene

23542

UniProt

Q13387 (UniProt - Evidence at protein level)

neXtProt

NX_Q13387

Antibodypedia

MAPK8IP2 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000008876
 
ENST00000329492
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK8IP2-001 ENSP00000330572
ENST00000329492
Q13387
Show all »
Show » Show » 824 88 No 0
MAPK8IP2-002 ENSP00000008876
ENST00000008876
Q13387
Show all »
Show » Show » 797 84.7 No 0