The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Normal tissues showed moderate to strong cytoplasmic and/or nuclear staining. Cilia of respiratory epithelia and fallopian tubes were distinctly stained. Lung alveolar cells, hepatocytes, pancreas, parathyroid, cells in glomeruli, smooth muscle and cells in the CNS were weakly stained or negative.
Most normal tissues displayed moderate cytoplasmic and/or nuclear positivity. Ovarian follicles, lymphoid reaction center cells and subset of neuronal cells were strongly stained. Liver, spleen, renal glomeruli and myocytes were weakly stained or negative.
Normal tissues showed moderate to strong nuclear positivity. Some cells showed additional weak cytoplasmic immunoreactivity. Nucleoli and mitotic figures were often distinctly stained.