The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed moderate to strong cytoplasmic and/or nuclear positivity. Bile ducts, decidual cells, prostate and renal glomeruli were negative.
Subset of cells in squamous epithelium, epididymis, trophoblastic cells, fallopian tube, epidermal cells, salivary gland, urothelial cells and keratinocytes of skin displayed strong nuclear positivity. Cells in seminiferous ducts showed moderate positivity. Remaining normal tissues were weakly stained or negative.
Most squamous epithelia and skin displayed strong nuclear positivity in a subset of cells. A subset of cells in fallopian tube, respiratory epithelium of nasopharynx, trophoblastic cells, cells in seminiferus ducts and urothelial cells exhibited moderate immunoreactivity. The adrenal and neuropil showed moderate cytoplasmic staining. Remaining normal tissues were mainly negative.
Subset of cells in most normal tissues showed strong nuclear staining. Salivary gland, decidual cells, hepatocytes, islets of Langerhans, thyroid, prostate and cardiac myocytes were negative.
Distinct nuclear staining was observed in proliferating cells. Most other cells were negative.