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ADGRA2
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  • ADGRA2
CELL LINE
BILE DUCT CANCER BLADDER CANCER BONE CANCER BRAIN CANCER BREAST CANCER CERVICAL CANCER COLORECTAL CANCER ESOPHAGEAL CANCER GALLBLADDER CANCER GASTRIC CANCER
HEAD AND NECK CANCER KIDNEY CANCER LEUKEMIA LIVER CANCER LUNG CANCER LYMPHOMA MYELOMA NEUROBLASTOMA NON-CANCEROUS OVARIAN CANCER
PANCREATIC CANCER PROSTATE CANCER RHABDOID SARCOMA SKIN CANCER TESTIS CANCER THYROID CANCER UNCATEGORIZED UTERINE CANCER
Human cell lines
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

ADGRA2
Gene descriptioni

Full gene name according to HGNC.

Adhesion G protein-coupled receptor A2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
G-protein coupled receptors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
HUMAN PROTEIN ATLAS INFORMATIONi

Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.

Cell line expression clusteri

The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

Read more
Connective tissue cells - ECM organization (mainly)
Cell line specificityi

RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

Read more
Cancer enhanced (Bone cancer)
Tau specificity scorei

Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

Read more
0.57
Cell line distributioni

RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.

Read more
Detected in many
Protein evidencei

Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.

Read more
Evidence at protein level
CELL LINESi

RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line section.

Read more
Cell line categories
Alphabetical
Expression
RNA specificity:Cancer enhanced (Bone cancer)

EXPRESSION CLUSTERING & CORRELATIONi

The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

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ADGRA2 is part of cluster 20 Connective tissue cells - ECM organization with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

Read more
1
611 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on cell line RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

Read more
Clusteri

ID of the expression cluster of the neighboring gene.

Read more
FBLN5 Fibulin 5 0.6093 20
GSTM5 Glutathione S-transferase mu 5 0.5991 20
PCDH18 Protocadherin 18 0.5972 20
LRRN4CL LRRN4 C-terminal like 0.5912 20
TBX5 T-box transcription factor 5 0.5898 20
SVEP1 Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.5615 20
ANGPTL2 Angiopoietin like 2 0.5590 20
PAMR1 Peptidase domain containing associated with muscle regeneration 1 0.5556 20
PODN Podocan 0.5511 20
MRGPRF MAS related GPR family member F 0.5489 20
C1QTNF5 C1q and TNF related 5 0.5367 20
LHFPL6 LHFPL tetraspan subfamily member 6 0.5337 20
ADAM33 ADAM metallopeptidase domain 33 0.5317 59
DDR2 Discoidin domain receptor tyrosine kinase 2 0.5299 59
EMILIN1 Elastin microfibril interfacer 1 0.5297 20

CELL LINE DATA
Alphabetical
Expression
Bile duct cancer (n=7)
Alphabetical
Expression
Bladder cancer (n=26)
Alphabetical
Expression
Bone cancer (n=19)
Alphabetical
Expression
Brain cancer (n=65)
Alphabetical
Expression
Breast cancer (n=50)
Alphabetical
Expression
Cervical cancer (n=3)
Alphabetical
Expression
Colorectal cancer (n=57)
Alphabetical
Expression
Esophageal cancer (n=27)
Alphabetical
Expression
Gallbladder cancer (n=1)
Alphabetical
Expression
Gastric cancer (n=38)
Alphabetical
Expression
Head and Neck cancer (n=33)
Alphabetical
Expression
Kidney cancer (n=31)
Alphabetical
Expression
Leukemia (n=88)
Alphabetical
Expression
Liver cancer (n=24)
Alphabetical
Expression
Lung cancer (n=196)
Alphabetical
Expression
Lymphoma (n=57)
Alphabetical
Expression
Myeloma (n=34)
Alphabetical
Expression
Neuroblastoma (n=17)
Alphabetical
Expression
Non-cancerous (n=60)
Alphabetical
Expression
Ovarian cancer (n=46)
Alphabetical
Expression
Pancreatic cancer (n=41)
Alphabetical
Expression
Prostate cancer (n=7)
Alphabetical
Expression
Rhabdoid (n=14)
Alphabetical
Expression
Sarcoma (n=14)
Alphabetical
Expression
Skin cancer (n=50)
Alphabetical
Expression
Testis cancer (n=1)
Alphabetical
Expression
Thyroid cancer (n=11)
Alphabetical
Expression
Uncategorized (n=10)
Alphabetical
Expression
Uterine cancer (n=28)

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.