FHL1

GENERAL INFORMATION

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Gene name

FHL1

Gene description

Four and a half LIM domains 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

17
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Distinct expression in muscle tissue and thyroid glands.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA001040 , HPA001391 , CAB020817
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

FHL1 (HGNC Symbol)

Synonyms

bA535K18.1, FHL1B, FLH1A, KYO-T, MGC111107, SLIM1, XMPMA

Description

Four and a half LIM domains 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

Chromosome

X

Cytoband

q26.3

Chromosome location (bp)

136147400 - 136211359

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000022267 (version 78.38)

Entrez gene

2273

UniProt

Q13642 (UniProt - Evidence at protein level)

neXtProt

NX_Q13642

Antibodypedia

FHL1 antibodies


PROTEIN BROWSER

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ENST00000345434
 
ENST00000370674
 
ENST00000370676
 
ENST00000370683
 
ENST00000370690
 
ENST00000394153
 
ENST00000394155
 
ENST00000420362
 
ENST00000434885
 
ENST00000449474
 
ENST00000452016
 
ENST00000456445
 
ENST00000458357
 
ENST00000535737
 
ENST00000539015
 
ENST00000543669
 
ENST00000618438
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FHL1-001 ENSP00000359724
ENST00000370690
Q13642
Show all »
Show » Show » 280 31.9 No 0
FHL1-002 ENSP00000071281
ENST00000345434
Q13642
Show all »
Show » Show » 323 36.3 No 0
FHL1-003 ENSP00000359710
ENST00000370676
Q5JXI2
Show all »
Show » Show » 210 23.7 No 0
FHL1-004 ENSP00000359717
ENST00000370683
Q13642
Show all »
Show » Show » 296 33.6 No 0
FHL1-006 ENSP00000391779
ENST00000420362
Q5JXH8
Show all »
Show » Show » 204 23.2 No 0
FHL1-007 ENSP00000359708
ENST00000370674
Q5JXI8
Show all »
Show » Show » 257 29.2 No 0
FHL1-008 ENSP00000408038
ENST00000452016
Q5JXI3
Show all »
Show » Show » 207 23.6 No 0
FHL1-010 ENSP00000413798
ENST00000434885
Q5JXI3
Show all »
Show » Show » 207 23.6 No 0
FHL1-011 ENSP00000389920
ENST00000458357
Q5JXH9
Show all »
Show » Show » 155 17.8 No 0
FHL1-012 ENSP00000412642
ENST00000456445
Q5JXH7
Show all »
Show » Show » 205 23.3 No 0
FHL1-013 ENSP00000414604
ENST00000449474
Q5JXI0
Show all »
Show » Show » 141 16.2 No 0
FHL1-201 ENSP00000377709
ENST00000394153
Q13642
Show all »
Show » Show » 280 31.9 No 0
FHL1-202 ENSP00000377710
ENST00000394155
Q13642
Show all »
Show » Show » 323 36.3 No 0
FHL1-203 ENSP00000444815
ENST00000535737
Q13642
Show all »
Show » Show » 280 31.9 No 0
FHL1-204 ENSP00000437673
ENST00000539015
Q13642
Show all »
Show » Show » 309 35 Yes 0
FHL1-205 ENSP00000443333
ENST00000543669
Q13642
Show all »
Show » Show » 280 31.9 No 0
FHL1-206 ENSP00000477609
ENST00000618438
Q13642
Show all »
Show » Show » 194 22 No 0