PRKCH

GENERAL INFORMATION

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Gene name

PRKCH

Gene description

Protein kinase C, eta

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA026294 , HPA053709 , CAB001998
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PRKCH (HGNC Symbol)

Synonyms

PKC-L, PKCL, PRKCL

Description

Protein kinase C, eta (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q23.1

Chromosome location (bp)

61187559 - 61550976

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000027075 (version 78.38)

Entrez gene

5583

UniProt

P24723 (UniProt - Evidence at protein level)

neXtProt

NX_P24723

Antibodypedia

PRKCH antibodies


PROTEIN BROWSER

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ENST00000332981
 
ENST00000553265
 
ENST00000553726
 
ENST00000553830
 
ENST00000553831
 
ENST00000555082
 
ENST00000555185
 
ENST00000555542
 
ENST00000555906
 
ENST00000556164
 
ENST00000556778
 
ENST00000557294
 
ENST00000557473
 
ENST00000557585
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCH-001 ENSP00000329127
ENST00000332981
P24723
Show all »
Show » Show » 683 77.8 No 0
PRKCH-002 ENSP00000450981
ENST00000555082
P24723
Show all »
Show » Show » 522 59.5 No 0
PRKCH-005 ENSP00000451930
ENST00000557585
G3V4Q6
Show all »
Show » Show » 224 25.1 No 0
PRKCH-006 ENSP00000452528
ENST00000557473
G3V5U5
Show all »
Show » Show » 106 12.5 No 0
PRKCH-014 ENSP00000451871
ENST00000555185
G3V4L3
Show all »
Show » Show » 151 17.2 No 0
PRKCH-015 ENSP00000451789
ENST00000555542
Show » 15 1.9 No 0
PRKCH-017 ENSP00000452588
ENST00000553830
G3V5Y6
Show all »
Show » Show » 144 16.6 No 0
PRKCH-019 ENSP00000450959
ENST00000553831
G3V304
Show all »
Show » Show » 83 9.8 No 0
PRKCH-020 ENSP00000451793
ENST00000553726
G3V4H0
Show all »
Show » Show » 53 5.6 No 0
PRKCH-021 ENSP00000451933
ENST00000553265
G3V4Q9
Show all »
Show » Show » 87 10.3 No 0
PRKCH-022 ENSP00000452330
ENST00000556164
G3V5F8
Show all »
Show » Show » 71 8.4 No 0
PRKCH-023 ENSP00000451205
ENST00000555906
G3V3E7
Show all »
Show » Show » 73 8.6 No 0
PRKCH-027 ENSP00000452129
ENST00000557294
G3V520
Show all »
Show » Show » 118 13.3 No 0
PRKCH-028 ENSP00000452055
ENST00000556778
G3V4X4
Show all »
Show » Show » 130 15.2 No 0