MCOLN3

GENERAL INFORMATION

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Gene name

MCOLN3

Gene description

Mucolipin 3

Protein class

Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enhanced (adrenal gland)

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in adrenal gland.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA018106 , HPA062137
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adrenal gland)

Organ

Expression



GENE INFORMATION

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Gene name

MCOLN3 (HGNC Symbol)

Synonyms

FLJ11006, TRP-ML3, TRPML3

Description

Mucolipin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

1

Cytoband

p22.3

Chromosome location (bp)

85018082 - 85048499

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000055732 (version 78.38)

Entrez gene

55283

UniProt

Q8TDD5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TDD5

Antibodypedia

MCOLN3 antibodies


PROTEIN BROWSER

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ENST00000341115
 
ENST00000370587
 
ENST00000370589
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCOLN3-001 ENSP00000359621
ENST00000370589
Q8TDD5
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Show » Show » 553 64.2 No 6
MCOLN3-002 ENSP00000342698
ENST00000341115
Q8TDD5
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Show » Show » 497 57.7 No 5
MCOLN3-006 ENSP00000359619
ENST00000370587
B1ANB7
Show all »
Show » 321 37.2 No 2