TRAF3IP2

GENERAL INFORMATION

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Gene name

TRAF3IP2

Gene description

TRAF3 interacting protein 2

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA036352
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TRAF3IP2 (HGNC Symbol)

Synonyms

ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, DKFZP586G0522

Description

TRAF3 interacting protein 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

111556454 - 111606278

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000056972 (version 78.38)

Entrez gene

10758

UniProt

O43734 (UniProt - Evidence at protein level)

neXtProt

NX_O43734

Antibodypedia

TRAF3IP2 antibodies


PROTEIN BROWSER

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ENST00000340026
 
ENST00000359831
 
ENST00000368735
 
ENST00000368761
 
ENST00000392556
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRAF3IP2-001 ENSP00000345984
ENST00000340026
O43734
Show all »
Show » Show » 574 64.7 No 0
TRAF3IP2-002 ENSP00000357724
ENST00000368735
O43734
Show all »
Show » Show » 109 12.8 No 0
TRAF3IP2-004 ENSP00000357750
ENST00000368761
O43734
Show all »
Show » Show » 565 63.6 No 0
TRAF3IP2-005 ENSP00000352889
ENST00000359831
O43734
Show all »
Show » Show » 564 63.5 No 0
TRAF3IP2-201 ENSP00000376339
ENST00000392556
O43734
Show all »
Show » Show » 574 64.7 No 0