The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed cytoplasmic staining of weak to moderate intensity, often only in a fraction of the cells. In proximal tubules of kidney, strong staining of luminal membranes was observed, in a few cells accompanied with nuclear positivity. Prostate showed strong immunoreactivity of both cytoplasm and nuclei. Distinct extra-cellular positivity inside lumina was common. Cells of CNS were negative.
Hepatocytes, melanocytes, adipocytes and a subset of cells in seminal vesicle and the neuronal cells of cerebral cortex showed moderate cytoplasmic staining. Fibroblasts and a subset of decidual cells exhibited strong positivity. Remaining normal tissues were weakly stained or negative.