CREB3L3

GENERAL INFORMATION

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Gene name

CREB3L3

Gene description

CAMP responsive element binding protein 3-like 3

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (duodenum, liver, small intestine)
GTEx:Group enriched (liver, small intestine)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues abundant in intestinal tract, hepatocytes heart and smooth muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA040671 , HPA056228
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (duodenum, liver, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (liver, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

CREB3L3 (HGNC Symbol)

Synonyms

CREB-H

Description

CAMP responsive element binding protein 3-like 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

4153601 - 4173054

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000060566 (version 78.38)

Entrez gene

84699

UniProt

Q68CJ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q68CJ9

Antibodypedia

CREB3L3 antibodies


PROTEIN BROWSER

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ENST00000078445
 
ENST00000595923
 
ENST00000602147
 
ENST00000602257
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CREB3L3-001 ENSP00000078445
ENST00000078445
Q68CJ9
Show all »
Show » Show » 461 49.1 No 1
CREB3L3-002 ENSP00000472399
ENST00000602257
Show » Show » 459 48.8 No 1
CREB3L3-003 ENSP00000470119
ENST00000602147
Show » 337 35.8 No 0
CREB3L3-005 ENSP00000469355
ENST00000595923
Show » Show » 460 48.9 No 1