COL11A1 protein expression summary - The Human Protein Atlas

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COL11A1

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Collagen type XI alpha 1 chain
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COL11A1 (CO11A1, COLL6, DFNA37, STL2)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (placenta, retina)
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - Hormone signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Theca cells, Excitatory neurons, Astrocytes)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Mixed function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Gene product is not prognostic
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Secreted (different isoforms)
Extracellular locationⁱ All genes with at least one isoform expected to be secreted to the extracellular environment have been annotated and classified either as secreted to blood or as locally secreted, depending on the predicted final location of the corresponding protein. Proteins expected to be locally secreted have been further classified according to their site of expression. Read more	Secreted to extracellular matrix
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Endoplasmic reticulum (Single cell variability)
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.... show less
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, Non-syndromic deafness, Stickler syndrome
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Calcium, Metal-binding
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - Hormone signaling (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (placenta, retina)
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Mixed function (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocyte precursor cells, Theca cells, Excitatory neurons, Astrocytes)

TISSUE CELL TYPEⁱ

Fibroblasts

Classificationⁱ

Core cell type enriched

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Prognostic summary	Gene product is not prognostic
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Cancer enhanced (breast cancer)
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in many

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Not detected - no cluster assigned
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. Read more	Secreted to extracellular matrix
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Endoplasmic reticulum
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	Variation in protein and transcript expression do not correlate to the cell-cycle.

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NES - Nervous system development (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22, BJ, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, HSkMC, SuSa)
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	COL11A1 (HGNC Symbol)
Synonyms	CO11A1, COLL6, DFNA37, STL2
Description	Collagen type XI alpha 1 chain (HGNC Symbol)
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	102876467 - 103108872
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Ensembl	ENSG00000060718 (version 103.38)
Entrez gene	1301
UniProt	P12107 (UniProt - Evidence at protein level)
neXtProt	NX_P12107
Antibodypedia	COL11A1 antibodies

PROTEIN BROWSERⁱ

COL11A1-201

COL11A1-202

COL11A1-203

COL11A1-204

COL11A1-205

COL11A1-206

COL11A1-209

COL11A1-212

COL11A1-213

COL11A1-214

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL11A1-201 ENSP00000302551 ENST00000353414	P12107 [Direct mapping] Collagen alpha-1(XI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005592 [collagen type XI trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030674 [protein-macromolecule adaptor activity] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0046872 [metal ion binding] GO:0050840 [extracellular matrix binding] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0062023 [collagen-containing extracellular matrix] Show all	1767 aa 176.6 kDa	Yes	0
COL11A1-202 ENSP00000351163 ENST00000358392	P12107 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001502 [cartilage condensation] GO:0001503 [ossification] GO:0002063 [chondrocyte development] GO:0003007 [heart morphogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005592 [collagen type XI trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006029 [proteoglycan metabolic process] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030674 [protein-macromolecule adaptor activity] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0035989 [tendon development] GO:0042472 [inner ear morphogenesis] GO:0046872 [metal ion binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048705 [skeletal system morphogenesis] GO:0050840 [extracellular matrix binding] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0051216 [cartilage development] GO:0055010 [ventricular cardiac muscle tissue morphogenesis] GO:0062023 [collagen-containing extracellular matrix] GO:1904399 [heparan sulfate binding] Show all	1818 aa 182.4 kDa	Yes	0
COL11A1-203 ENSP00000359114 ENST00000370096	P12107 [Direct mapping] Collagen alpha-1(XI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005592 [collagen type XI trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030674 [protein-macromolecule adaptor activity] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0046872 [metal ion binding] GO:0050840 [extracellular matrix binding] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0062023 [collagen-containing extracellular matrix] Show all	1806 aa 181.1 kDa	Yes	0
COL11A1-204 ENSP00000408640 ENST00000427239	C9JMN2 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		569 aa 61.9 kDa	Yes	0
COL11A1-205 ENSP00000410177 ENST00000447608	H7C381 [Direct mapping] Collagen alpha-1(XI) chain Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		200 aa 22.5 kDa	No	0
COL11A1-206 ENSP00000494909 ENST00000461720	A0A2R8YDU3 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		780 aa 82.9 kDa	Yes	0
COL11A1-209 ENSP00000426533 ENST00000512756	P12107 [Direct mapping] Collagen alpha-1(XI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005592 [collagen type XI trimer] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030674 [protein-macromolecule adaptor activity] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0046872 [metal ion binding] GO:0050840 [extracellular matrix binding] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0062023 [collagen-containing extracellular matrix] Show all	1690 aa 167.8 kDa	Yes	0
COL11A1-212 ENSP00000493821 ENST00000644186	A0A2R8Y4I5 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		736 aa 77.8 kDa	Yes	0
COL11A1-213 ENSP00000494179 ENST00000645458	A0A2R8Y4M5 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		729 aa 77.1 kDa	Yes	0
COL11A1-214 ENSP00000494583 ENST00000647280	A0A2R8Y5N4 [Direct mapping] Collagen alpha-1(XI) chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Nervous system diseases Eye disease Protein evidence (Ezkurdia et al 2014) Show all		756 aa 80.4 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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