The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal cells showed weak to moderate nuclear positivity. Peripheral nerves displayed distinct nuclear positivity. A strong cytoplasmic and membranous positivity was found in the myoepithelial cells in breast as well as basal cells in epididymis and prostate glands. Germinal centre cells in lymphoid tissues showed a reticular pattern of immunoreactivity.
Endothelial cells in renal glomeruli and blood vessels in lymphoid tissues, mainly in germinal centra, were strongly stained. Basal cells in most squamous epithelia, prostate, seminal vesicle and breast were distinctly stained. Myoepithelial cells in breast and peripheral nerves showed distinct positivity. Remaining normal cells generally were negative.
Strong membranous staining was observed in basal cells of squamous epithelia, prostate gland and airway epithelia. Strong positivity was also found in lymphoid follicles. Remaining normal tissues were in general negative.