CTSA

GENERAL INFORMATION

? »

Gene name

CTSA

Gene description

Cathepsin A

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous granular cytoplasmic expression.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA031068 , CAB024930
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

CTSA (HGNC Symbol)

Synonyms

GSL, PPGB

Description

Cathepsin A (HGNC Symbol)

Entrez gene summary

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

45890144 - 45898820

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064601 (version 78.38)

Entrez gene

5476

UniProt

P10619 (UniProt - Evidence at protein level)

neXtProt

NX_P10619

Antibodypedia

CTSA antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000191018
 
ENST00000354880
 
ENST00000372459
 
ENST00000372484
 
ENST00000419493
 
ENST00000607482
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSA-001 ENSP00000361562
ENST00000372484
X6R8A1
Show all »
Show » Show » 498 56.2 Yes 0
CTSA-004 ENSP00000191018
ENST00000191018
P10619
Show all »
Show » Show » 480 54.5 Yes 0
CTSA-006 ENSP00000346952
ENST00000354880
X6R5C5
Show all »
Show » Show » 481 54.3 Yes 0
CTSA-012 ENSP00000361537
ENST00000372459
P10619
Show all »
Show » Show » 480 54.5 Yes 0
CTSA-016 ENSP00000475524
ENST00000607482
U3KQ41
Show all »
Show » Show » 110 12 Yes 0
CTSA-020 ENSP00000408533
ENST00000419493
Q5JZH0
Show all »
Show » Show » 202 22.2 No 0