SLC12A2

GENERAL INFORMATION

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Gene name

SLC12A2

Gene description

Solute carrier family 12 (sodium/potassium/chloride transporter), member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA020130
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SLC12A2 (HGNC Symbol)

Synonyms

BSC, BSC2, NKCC1, PPP1R141

Description

Solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

5

Cytoband

q23.3

Chromosome location (bp)

128083766 - 128189688

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064651 (version 78.38)

Entrez gene

6558

UniProt

P55011 (UniProt - Evidence at protein level)

neXtProt

NX_P55011

Antibodypedia

SLC12A2 antibodies


PROTEIN BROWSER

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ENST00000262461
 
ENST00000343225
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC12A2-001 ENSP00000262461
ENST00000262461
P55011
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Show » Show » 1212 131.4 No >9
SLC12A2-004 ENSP00000340878
ENST00000343225
P55011
Show all »
Show » Show » 1196 129.7 No >9