The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal and cancer tissues showed moderate cytoplasmic immunoreactivity and that in cases was combined with membranous positivity. Strong staining was for example observed in endometrial glands, seminiferous ducts, neurons and placenta. Alveolar cells, squamous epithelia, adrenal cortex, cells in red pulp of spleen and liver were weakly stained or negative.
Most of the normal tissues showed moderate to strong cytoplasmic immunoreactivity with a granular pattern combined with nuclear staining in a few cases. Lung, squamous epithelium, spleen, heart and skeletal myocytes were weakly stained or negative.
Most normal tissues showed moderate nuclear and cytoplasmic positivity. The small intestine, exocrine pancreas, gall bladder, adrenal cortex, placental trophoblasts and neurons were strongly stained.