GUCY2C

GENERAL INFORMATION

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Gene name

GUCY2C

Gene description

Guanylate cyclase 2C (heat stable enterotoxin receptor)

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (colon, duodenum, rectum, small intestine)
GTEx:Group enriched (colon, small intestine)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression mainly in intestine. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending retesting.

Data reliability

Uncertain based on 1 antibody.
HPA037655
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (colon, duodenum, rectum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (colon, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

GUCY2C (HGNC Symbol)

Synonyms

GUC2C, STAR

Description

Guanylate cyclase 2C (heat stable enterotoxin receptor) (HGNC Symbol)

Entrez gene summary

Chromosome

12

Cytoband

p12.3

Chromosome location (bp)

14612632 - 14696585

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070019 (version 78.38)

Entrez gene

2984

UniProt

P25092 (UniProt - Evidence at protein level)

neXtProt

NX_P25092

Antibodypedia

GUCY2C antibodies


PROTEIN BROWSER

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ENST00000261170
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GUCY2C-001 ENSP00000261170
ENST00000261170
P25092
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