CNGB1

GENERAL INFORMATION

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Gene name

CNGB1

Gene description

Cyclic nucleotide gated channel beta 1

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

External RNA data suggests expression in hypothalamus. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending additional tissues.

Data reliability

Uncertain based on 2 antibodies.
HPA039159 , HPA060355
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland, cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

CNGB1 (HGNC Symbol)

Synonyms

CNCG2, CNCG3L, CNGB1B, GAR1, GARP, RCNC2, RCNCb, RP45

Description

Cyclic nucleotide gated channel beta 1 (HGNC Symbol)

Entrez gene summary

In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

57882340 - 57971116

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070729 (version 78.38)

Entrez gene

1258

UniProt

Q14028 (UniProt - Evidence at protein level)

neXtProt

NX_Q14028

Antibodypedia

CNGB1 antibodies


PROTEIN BROWSER

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ENST00000251102
 
ENST00000311183
 
ENST00000562761
 
ENST00000564448
 
ENST00000565942
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNGB1-001 ENSP00000251102
ENST00000251102
Q14028
Show all »
Show » Show » 1251 139.7 No 5
CNGB1-002 ENSP00000311670
ENST00000311183
Q14028
Show all »
Show » Show » 299 32.5 No 0
CNGB1-003 ENSP00000454633
ENST00000564448
Q14028
Show all »
Show » Show » 1245 139.2 No 5
CNGB1-004 ENSP00000455708
ENST00000562761
H3BQC3
Show all »
Show » 214 23.5 No 0
CNGB1-008 ENSP00000455964
ENST00000565942
Show » 127 13.9 No 0