TRIB2

GENERAL INFORMATION

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Gene name

TRIB2

Gene description

Tribbles pseudokinase 2

Protein class

Cytoskeleton related proteins
Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong immunoreactivity was observed in thyroid gland, spleen, brain and vascular tissue. Remaining normal tissues were in general weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001305
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TRIB2 (HGNC Symbol)

Synonyms

GS3955, TRB2

Description

Tribbles pseudokinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

2

Cytoband

p24.3

Chromosome location (bp)

12716889 - 12742734

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000071575 (version 78.38)

Entrez gene

28951

UniProt

Q92519 (UniProt - Evidence at transcript level)

neXtProt

NX_Q92519

Antibodypedia

TRIB2 antibodies


PROTEIN BROWSER

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ENST00000155926
 
ENST00000381465
 
ENST00000405331
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIB2-001 ENSP00000155926
ENST00000155926
Q92519
Show all »
Show » Show » 343 38.8 No 1
TRIB2-002 ENSP00000370874
ENST00000381465
F8WA18
Show all »
Show » Show » 207 23.6 No 1
TRIB2-004 ENSP00000384260
ENST00000405331
B5MCX4
Show all »
Show » Show » 252 28.5 No 2